Discovery and Characterization of Genes Conferring Natural Resistance to the Antituberculosis Antibiotic Capreomycin
Chin-Yuan Chang,
Toh Ing,
Johan Elaine Keisha
et al.
Abstract:Metagenomic-based studies have predicted an extraordinary number of potential antibiotic-resistant genes (ARGs). These ARGs are hidden in various environmental bacteria and may become a latent crisis for antibiotic therapy via horizontal gene transfer. In this study, we focus on a resistance gene cph, which encodes a phosphotransferase (Cph) that confers resistance to the antituberculosis drug capreomycin (CMN). Sequence Similarity Network analysis classified 353 Cph homologues into five major clusters. We exa… Show more
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