A paper-based chemiresistive biosensor employing single-walled carbon nanotubes for low-cost, point-of-care detection

Shen, Yu; Tran, Thien-Toan; Modha, Sidharth; Tsutsui, Hideaki; Mulchandani, Ashok

doi:10.1016/j.bios.2018.09.041

Cited by 66 publications

(34 citation statements)

References 37 publications

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“…A broad spectrum of compounds that find applications in healthcare diagnosis and POC analysis of diseases can be detected with such biosensor materials [22]. Carbon allotrope-based nanomaterials consisting of fullerenes, [23,24,25,26,27] nanotubes (CNT) [28,29,30,31,32,33], films of graphene and its derivatives [34,35,36,37], quantum dots [38,39,40,41], and nanodiamonds [42,43,44,45,46,47] play a substantial role in recent advancements in the biosensor domain. In addition to greater sensitivity and novel mechanisms, such sensors offer a higher spatial resolution in case of localised detection along with real-time and label-free non-destructive sensing.…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

“…Lactate detection between 10 and 200 µM was possible following lactate oxidase (LOx) immobilisation on the sensor and a very low detection limit (2.4 µM) was obtained. Shen et al reported a chemiresistive paper-based label-free immunosensor for cost-effective POC detection using SWCNT [33]. They harnessed the non-covalent π–π stacking interactions between SWCNT and pyrene carboxylic acid (PCA) to synthesise a water-based ink prior to human serum albumin (HSA) antibody immobilisation.…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

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Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

161

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

161

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“…Coupling of the devices with new applications on smart phones for personal health check will greatly impact the health care system. Examples on novel designs and fabrication techniques include a flow controllable 3D‐PAD fabricated by 3D‐printing technology using digital light processing stereolithography for the detection of glucose and albumin , a vacuum filtration assisted wax printing‐PAD chemiresistive biosensor using single‐walled carbon nanotubes as a low cost POC detection of human serum albumin , and a filtration‐assisted screen printing‐PAD for glucose detection . A Janus (two‐faced Greek god)‐electrochemical paper device was proposed for simultaneous analysis of norepinephrine, serotonin, and p‐aminophenol in a sample .…”

Section: Future Outlookmentioning

confidence: 99%

Recent applications of paper‐based point‐of‐care devices for biomarker detection

Suntornsuk

2019

Electrophoresis

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Detection of biomarkers is essential for diagnosis and prognosis of diseases for healthcare teams to provide timely appropriate treatments. Reliable, inexpensive, and sensitive devices are desirable to serve this purpose. Paper‐based analytical devices (PADs) have gained enormous attention during the past decade as point‐of‐care devices for biomarker detection due to their simplicity, portability, and biocompatibility. Importantly, the devices highly comply with the WHO “ASSURED” concept (i.e. Affordable, Sensitive, Specific, User‐friendly, Rapid and Robust, Equipment free, and Deliverable to end‐users). Thus, PADs could be sustainably alternative tools for biomarker detection, especially in resources‐constraint areas where budget, skillful operators, and health infrastructure are limited. First, this review introduces overviews of biomarkers, their detection and brief history of PADs. Second, description of common fabrication and detection techniques in PADs are provided. Then, it highlights recent state of the art technologies and applications of PADs for various biomarker detection published during 2018 to May 2019. Applications for tumor marker, cardiac and coronary heath disease, and metabolic disorder biomarker detection are tabulated and selected examples are described in details. Finally, it discusses the current challenges, advances, and novel applications of PADs. The review would be valuable for healthcare workers using PADs as cost‐effective point‐of‐care devices for biomarker detection and for researchers working on future developments of the devices.

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“…Developing sensitive and reliable point-of-care (POC) devices for early cancer screening, diagnosis, and treatment monitoring is an important task in both the developing and developed world [1,2]. Promising interdisciplinary research grows on this context because POC analytical platforms can reduce cost, decrease the sample amount, achieve an on-site diagnosis and mitigate patient stress [3,4]. Additionally, with the discovery of tumor biomarkers, such as alpha-fetoprotein, prostate specific antigen (PSA) and carcinoembryonic antigen (CEA), the feasibility of analysis in oncology has been enhanced [5].…”

Section: Introductionmentioning

confidence: 99%

A Graphene-PEDOT:PSS Modified Paper-Based Aptasensor for Electrochemical Impedance Spectroscopy Detection of Tumor Marker

Yen

Chao

Yeh

2020

Sensors

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A graphene and poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) modified conductive paper-based electrochemical impedance spectroscopy (EIS) aptasensor has been successfully fabricated by a simple and continuous coating process. A graphene/PEDOT:PSS modified paper electrode forms the nanocomposite providing a conductive and sensitive substrate for further aptamer functionalization of the biosensor. This low-cost paper-based aptasensor exhibits its sensitivity to carcinoembryonic antigens (CEA) in standard buffer solutions and human serum samples in a linear range of 0.77–14 ng·mL−1. The limit of detection (LOD) is found to be 0.45 ng·mL−1 and 1.06 ng·mL−1 for CEA in both samples, separately. This aptamer-based sensing device was also evaluated and received a good correlation with the immunoassay detection method. The proposed paper-based aptasensor has demonstrated its potential as a rapid simple point-of-care analytical platform for early cancer diagnosis in less developed areas where manufacturing facilities, analytical instruments, and trained specialists are limited.

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A paper-based chemiresistive biosensor employing single-walled carbon nanotubes for low-cost, point-of-care detection

Cited by 66 publications

References 37 publications

Nanomaterials for Healthcare Biosensing Applications

Nanomaterials for Healthcare Biosensing Applications

Recent applications of paper‐based point‐of‐care devices for biomarker detection

A Graphene-PEDOT:PSS Modified Paper-Based Aptasensor for Electrochemical Impedance Spectroscopy Detection of Tumor Marker

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