A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma

Li, Rongkang; Lu, Chong; Yang, Weiqiang; Zhou, Yuwen; Zhong, Jiatao; Chen, Xuan; Li, Xinji; Huang, Guoxin; Peng, Xiqi; Liu, Kaihao; Zhang, Chunduo; Hu, Hongyi; Lai, Yongqing

doi:10.1002/jcla.24194

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Many studies considered circulating miRNA could serve as a biomarker of ESCC and most of them reported an AUC around 0.7, 30 similar to our results. In addition, numerous studies have demonstrated that the combination of multiple miRNAs can achieve higher diagnostic efficacy than single miRNAs in tumor patients 31–34 . Therefore, we combined four plasma EVs‐derived miRNA for the diagnosis of ESCC, and the combination model showed optimum diagnostic capabilities for the detection of ESCC (AUC = 0.834), which was higher than that of total plasma miRNA panels (Figure 5D and Table S9).…”

Section: Resultsmentioning

confidence: 92%

“…In addition, numerous studies have demonstrated that the combination of multiple miRNAs can achieve higher diagnostic efficacy than single miRNAs in tumor patients. 31 , 32 , 33 , 34 Therefore, we combined four plasma EVs‐derived miRNA for the diagnosis of ESCC, and the combination model showed optimum diagnostic capabilities for the detection of ESCC (AUC = 0.834), which was higher than that of total plasma miRNA panels (Figure 5D and Table S9 ). Thus, combining plasma EV‐derived miR‐636, miR‐7641, miR‐1246, and miR‐28‐3p model had better diagnostic efficiency for ESCC.…”

Section: Resultsmentioning

confidence: 97%

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Identification of combinatorial miRNA panels derived from extracellular vesicles as biomarkers for esophageal squamous cell carcinoma

Wang,

Li,

Wei

et al. 2023

MedComm

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MicroRNAs (miRNAs) are relatively stable in blood, emerging as one of the most promising biomarkers in tumor liquid biopsy. Both total and extracellular vesicles (EVs) encapsulated miRNA have been studied for prognostic potential in a variety of cancers. Here, we systematically compared and verified the total and vesicle‐derived miRNA expression profiles from plasma samples in healthy controls and patients with esophageal squamous cell carcinoma (ESCC). In the present study, four miRNA species miR‐636, miR‐7641, miR‐28‐3p, and miR‐1246 that were differentially expressed in ESCC patients were chosen for further study. We first elucidated their essential function in ESCC progression and further explored their preliminary mechanism by identifying target proteins and involving signal pathways. Subsequently, the prognostic miRNA panels including miR‐636, miR‐7641, miR‐1246, and miR‐28‐3p for ESCC diagnosis were constructed and validated using different cohort. Our results showed that the panel including the above four miRNAs derived from plasma EVs was most effective in distinguishing tumor patients from normal subjects, while integrated plasma EVs‐derived miR‐1246, miR‐28‐3p and total plasma miRNAs miR‐636, miR‐7641 showed the best capability in predicting lymph node metastasis. In summary, our studies revealed that plasma EVs‐derived miRNAs could be emerged as promising biomarkers for ESCC diagnosis.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 97%

Identification of combinatorial miRNA panels derived from extracellular vesicles as biomarkers for esophageal squamous cell carcinoma

Wang,

Li,

Wei

et al. 2023

MedComm

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“…An extensive number of studies have demonstrated that miRNAs are involved in various biological processes, including tumor angiogenesis and vascular-related disorders ( Pourrajab et al, 2015 ; Mashreghi, 2017 ). In addition, some miRNAs have been reported as biomarkers of specific diseases ( Mariam et al, 2022 ), especially in tumors ( Li et al, 2022 ; Tu et al, 2022 ). Nonetheless, there are fewer studies focused on the comprehensive miRNA-gene interaction in IH.…”

Section: Introductionmentioning

confidence: 99%

Identification of Key microRNAs and Genes in Infantile Hemangiomas

Yang

Zou

et al. 2022

Front. Genet.

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Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy. Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases. However, the function of miRNAs in IH still remains largely unknown. In the present study, we performed a miRNA microarray analysis of IH and identified 68 differentially expressed miRNAs (DEMs). In addition, miRNA-gene networks and protein-protein interactions were constructed, and the hub miRNAs and genes of IH were screened out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were used for biological analysis of DEMs and differentially expressed genes (DEGs). The pathway enrichment analysis of DEMs revealed several tumor-related pathways, including proteoglycans in cancer, signaling pathway regulating pluripotency of stem cells and TGF-beta signaling pathway. DEGs were mainly enriched in biological processes, including intracellular signal transduction, cell adhesion, and cell death. KEGG pathway analysis indicated that DEGs were enriched in tumorigenesis- and angiogenesis-related pathways such as proteoglycans in cancer, MAPK signaling pathway and Rap1 signaling pathway. Collectively, this study first established a comprehensive miRNA-gene network in IH, which should provide novel insights into IH pathogenesis and be beneficial to the understanding of neovascularization-related disorders.

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