2010
DOI: 10.1371/journal.pone.0009954
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A Pair of Dopamine Neurons Target the D1-Like Dopamine Receptor DopR in the Central Complex to Promote Ethanol-Stimulated Locomotion in Drosophila

Abstract: Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of ethanol in flies are not known. We show that a subset of dopamine neurons and their targets, through the action of the D1-like dopamine receptor DopR, promote locomotor activation in response to acute ethanol exposure. A bilateral pair of dopaminergic neurons in the fly brain mediates the enhanced locomotor activity induced by et… Show more

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Cited by 171 publications
(266 citation statements)
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“…S5B). Ddc-GAL4 and TH-GAL4 share expression with the exception of a subset of neurons termed the PAM neurons (33) (Fig. 2 B and C).…”
Section: Oviposition Preference Depends On the Context Of The Egg-layingmentioning
confidence: 98%
See 3 more Smart Citations
“…S5B). Ddc-GAL4 and TH-GAL4 share expression with the exception of a subset of neurons termed the PAM neurons (33) (Fig. 2 B and C).…”
Section: Oviposition Preference Depends On the Context Of The Egg-layingmentioning
confidence: 98%
“…To test this, we blocked neurotransmission with TeTx in patterns specified by three GAL4 lines that drive expression in various subsets of Ddc-expressing cells including the PAM neurons (transgenes HL5, HL7, and HL9) (33,35). Blocking neurotransmission in PAM, PAL, PPM1/2, PPL2, and Sb neurons (HL5) decreased oviposition preference for 5% ethanol (Fig.…”
Section: Different Subsets Of Dopamine Neurons Drive Competing Behavimentioning
confidence: 99%
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“…All circadian experiments are conducted using dim red light (ambient overhead red light < 1 lux on bench top; small red lights used at 12 inches from tubes ~ 1 lux light). (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) flies using an aspirator on day 2 towards the end of the light period, and transfer to fresh holding vials. 4.…”
Section: Preparation Of Experimental Animalsmentioning
confidence: 99%