A numerical study on thermal ablation of brain tumor with intraoperative focused ultrasound

Abdolhosseinzadeh, Amir; Mojra, Afsaneh; Ashrafizadeh, Ali

doi:10.1016/j.jtherbio.2019.05.019

Cited by 15 publications

(7 citation statements)

References 31 publications

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“…The numerical results were compared with known solutions available in the literature [41]. For validation of the computational domain, acoustic and thermophysical properties and the other operating parameters like frequency, focal length and aperture were kept identical to a previous study.…”

Section: Validationmentioning

confidence: 99%

“…For validation of the computational domain, acoustic and thermophysical properties and the other operating parameters like frequency, focal length and aperture were kept identical to a previous study. [41]. Following the approach of Abdolhosseinzadeh et al, [41], the simulation was performed at two different normal displacements of 5 nm and 1 nm keeping the frequency at 1 MHz.…”

Section: Validationmentioning

confidence: 99%

“…[41]. Following the approach of Abdolhosseinzadeh et al, [41], the simulation was performed at two different normal displacements of 5 nm and 1 nm keeping the frequency at 1 MHz. The axial variation of absolute acoustic pressure (as shown in Fig.…”

Section: Validationmentioning

confidence: 99%

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Pulsed Ultrasound Assisted Thermo-Therapy for Subsurface Tumor Ablation: A Numerical Investigation

Singh

Paul

Shekhar

et al. 2021

Journal of Thermal Science and Engineering Applications

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High Intensity Focused Ultrasound (HIFU) is a promising therapy for thermal ablation and hyperthermia, characterised by it noninvasiveness, high penetration depth. Effective HIFU thermo-therapy requires the ability to accurately predict temperature elevation and corresponding thermal dose distribution in target tissues. We report a parametric numerical study of the thermal response and corresponding of thermal dose in a soft tissue in response to ultrasound. We compared the predictions of tissue models with two, three and seven layers, to ultrasound induced heating at duty cycles ranging from 0.6 and 0.9. Further, two tumor sizes and transducer powers (10 W and 15 W) were considered. Inhomogeneous Helmholtz equation was coupled with Pennes bio-heat equation to predict heating in response to pulsed ultrasound. Necrotic lesion size was calculated using the cumulative equivalent minute (CEM) thermal dose function. In-vitro experiments were performed with agar-based tissue phantoms as a preliminary validation of the numerical results. The simulations conducted with the seven layered model predicted up to 33.5% lower peak pressure amplitude than the three-layered model. As the ultrasound pulse width decreased with the equivalent sonication time fixed, the corresponding magnitude of the peak temperature and the rate of temperature rise decreased. Pulsed ultrasound resulted in increased the volume of necrotic lesions for equivalent time of sonication. The findings of this study highlight the dependence of HIFU-induced heating on target geometry and acoustic properties, and could help guide the choice of suitable ultrasound exposure parameters for further studies.

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Section: Validationmentioning

confidence: 99%

Section: Validationmentioning

confidence: 99%

See 1 more Smart Citation

Pulsed Ultrasound Assisted Thermo-Therapy for Subsurface Tumor Ablation: A Numerical Investigation

Singh

Paul

Shekhar

et al. 2021

Journal of Thermal Science and Engineering Applications

View full text Add to dashboard Cite

show abstract

“…A later 2014 study overcame power related issues, but was limited by acoustic impedance through bone attenuation, time required for ablation and effects on healthy tissues [ 76 ]. Recently, many studies have attained pre-clinical success in achieving controlled ablation of the tumoral tissue by modification of acoustic specifications [ 77 , 78 ]. For example, when the transducer parameters including power, duty cycle and frequency are controlled a functional thermal dose can be obtained [ 77 ].…”

Section: Clinical Impact Of Fus Mediated Bbb/btb Disruptionmentioning

confidence: 99%

“…Recently, many studies have attained pre-clinical success in achieving controlled ablation of the tumoral tissue by modification of acoustic specifications [ 77 , 78 ]. For example, when the transducer parameters including power, duty cycle and frequency are controlled a functional thermal dose can be obtained [ 77 ]. A recent study evaluated BTB disruption using FUS with adjuvant temozolomide and showed accurate and safe opening in patients for six sonication cycles at the same targeted sites [ 74 ].…”

Section: Clinical Impact Of Fus Mediated Bbb/btb Disruptionmentioning

confidence: 99%

Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery

et al. 2021

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The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrier, known as the blood-tumor barrier (BTB). Despite the change in integrity, the BTB remains effective in preventing delivery of chemotherapy into brain tumors. Focused ultrasound is a unique noninvasive technique that can transiently disrupt the BBB and increase accumulation of drugs within targeted areas of the brain. Herein, we summarize the current understanding of different types of targeted ultrasound mediated BBB/BTB disruption techniques. We also discuss influence of the tumor microenvironment on BBB opening, as well as the role of immunological response following disruption. Lastly, we highlight the gaps between evaluation of the parameters governing opening of the BBB/BTB. A deeper understanding of physical opening of the BBB/BTB and the biological effects following disruption can potentially enhance treatment strategies for patients with brain tumors.

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Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma

et al. 2023

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Glioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have emerged as promising approaches for the treatment of GB. SDT uses ultrasound waves in combination with a sonosensitizer to selectively damage cancer cells, while MRgFUS delivers high-intensity ultrasound waves to precisely target tumor tissue and disrupt the blood–brain barrier to enhance drug delivery. In this review, we explore the potential of SDT as a novel therapeutic strategy for GB. We discuss the principles of SDT, its mechanisms of action, and the preclinical and clinical studies that have investigated its use in Gliomas. We also highlight the challenges, the limitations, and the future perspectives of SDT. Overall, SDT and MRgFUS hold promise as novel and potentially complementary treatment modalities for GB. Further research is needed to optimize their parameters and determine their safety and efficacy in humans, but their potential for selective and targeted tumor destruction makes them an exciting area of investigation in the field of brain cancer therapy.

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A numerical study on thermal ablation of brain tumor with intraoperative focused ultrasound

Cited by 15 publications

References 31 publications

Pulsed Ultrasound Assisted Thermo-Therapy for Subsurface Tumor Ablation: A Numerical Investigation

Pulsed Ultrasound Assisted Thermo-Therapy for Subsurface Tumor Ablation: A Numerical Investigation

Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery

Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma

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