A numerical-experimental method for a mechanical characterization of biological materials

Oomens, Cwj Cees; Ratingen, Michiel van; Janssen, JD Jan; Kok, JJ Jan; Hendriks, Man Max

doi:10.1016/0021-9290(93)90024-9

Cited by 53 publications

(27 citation statements)

References 4 publications

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“…30,[31][32]33,34,35,36,37,38,39,40,41 In general, these "inverse methods" assume a constitutive equation for the material, and estimate the material coefficients by simulating experimental force-deformation data with a computer model (review 41 ).…”

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confidence: 99%

Nonlinear elastic material property estimation of lower extremity residual limb tissues

Tönük

Silverthorn

2003

IEEE Trans. Neural Syst. Rehabil. Eng.

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The interface stresses between the residual limb and prosthetic socket have been studied to investigate prosthetic fit. Finite-element models of the residual limb-prosthetic socket interface facilitate investigation of the mechanical interface and may serve as a potential tool for future prosthetic socket design. However, the success of such residual limb models to date has been limited, in large part due to inadequate material formulations used to approximate the mechanical behavior of residual limb soft tissues. Nonlinear finite-element analysis was used to simulate force-displacement data obtained during in vivo rate-controlled (1, 5, and 10 mm/s) cyclic indentation of the residual limb soft tissues of seven individuals with transtibial amputation. The finite-element models facilitated determination of an appropriate set of nonlinear elastic material coefficients for bulk soft tissue at discrete clinically relevant test locations. Axisymmetric finite-element models of the residual limb bulk soft tissue in the vicinity of the test location, the socket wall and the indentor tip were developed incorporating contact analysis, large displacement, and large strain, and the James-Green-Simpson nonlinear elastic material formulation. Model dimensions were based on medical imaging studies of the residual limbs. The material coefficients were selected such that the normalized sum of square error (NSSE) between the experimental and finite-element model indentor tip reaction force was minimized. A total of 95% of the experimental data were simulated using the James-Green-Simpson material formulation with an NSSE NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. Engineering, Vol 11, No. 1 (March 2003): 43-53. DOI. This article is © Institute of Electrical and Electronics Engineers (IEEE) and permission has been granted for this version to appear in e-Publications@Marquette. Institute of Electrical and Electronics Engineers (IEEE) does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Institute of Electrical and Electronics Engineers (IEEE). IEEE Transactions on Neural Systems and Rehabilitation2 less than 5%. The respective James-Green-Simpson material coefficients varied with subject, test location, and indentation rate. Therefore, these coefficients cannot be readily extrapolated to other sites or individuals, or to the same site and individual some time after testing. NomenclatureNonlinear elastic material coefficients; subscript indicates the order in strain invariant.Nonlinear elastic material coefficients in James-Green-Simpson material model; = order in first strain invariant 1 ; = order in second strain invariant 2 .Components of Green-Lagrange finite strain tensor.

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confidence: 99%

Nonlinear elastic material property estimation of lower extremity residual limb tissues

Tönük

Silverthorn

2003

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…It can be expected that the stress-strain distribution would be less uniform in an anisotropic tissue, even though direct experimental evidence would be needed. Nevertheless, Oomens et al [36] claim that a homogeneous strain field cannot be obtained because of the inhomogeneous material properties and the challenging (sometimes impossible) manufacturing of sample. Anyhow, in this work about the 5% of the gauge area (from hooks to hooks) was considered for the stress-strain curves extraction.…”

Section: Resultsmentioning

confidence: 99%

Equi-Biaxial Tests for Mechanical Characterization of Human Acellular Dermal Matrices Through a Custom-Made Biaxial Fixture

Terzini¹,

Aldieri²,

Bignardi³

et al. 2017

Materials and Contact Characterisation VIII

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Human Acellular Dermal Matrices (HADMs) have recently been employed in reconstructive surgeries which involve high mechanical resistance prerequisites (e.g. rotator cuff tears repair, Achilles tendon augmentation, breast reconstruction procedure, hernia repair), having proved its non-immunogenic response and promising mechanical properties. Nevertheless, a thorough mechanical characterization is needed in order to test HADMs response when subjected to stress levels comparable to those experienced in vivo, to confirm its applicability to the above mentioned surgical fields and to provide precise indications to surgeons. HADMs specimens have undergone biaxial tests through a custom made biaxial fixture interfaced with a uniaxial universal testing machine. Stress-strain curves were evaluated from biaxial loads measured by two load cells, and the optical measure of the displacement of four markers located in central area of specimens. Comparisons among the native human reticular dermis and HADMs demonstrated the loss of mechanical strength caused by the decellularization process. Moreover, the specimens resulted, on average, less extensible in the medio-lateral direction (namely, along the Langer lines) than in the cranio-caudal direction, confirming the correlation of dermis mechanical response with collagen fibers orientation.

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“…Therefore, local tissue strains in the valve can be directly obtained from measured volumetric deformation values. The conventional numerical-experimental approach 30 of determining material properties and local strain values by using experimentally measured quantities is very time-consuming and can be avoided by using this direct relation. The relation between volumetric deformation and local tissue strain is most sensitive for variations in thickness; the maximum standard deviation in local strain values at a constant volumetric deformation was 25%.…”

Section: Discussionmentioning

confidence: 99%

“…6 When material properties in the circumferential and radial direction of the heart valve are significantly different, the anisotropic model can be applied to assess local deformations by using the conventional numerical-experimental approach, mentioned earlier. 30 The tissue engineering experiment demonstrated the possibility to measure volumetric deformation of the heart valve leaflets during mechanical conditioning, in real-time and non-invasively. Local strain values assessed by the numerical model were maximal 6% (belly), 10% (commissural region) or 7% (entire leaflet).…”

Section: Discussionmentioning

confidence: 99%

Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

et al. 2008

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Abstract-In heart valve tissue engineering, most bioreactors try to mimic physiological flow and operate with a preset transvalvular pressure applied to the tissue. The induced deformations are unknown and can vary during culturing as a consequence of changing mechanical properties of the engineered construct. Real-time measurement and control of local tissue strains are desired to systematically study the effects of mechanical loading on tissue development and, consequently, to design an optimal conditioning protocol. In this study, a method is presented to assess local tissue strains in heart valve leaflets during culturing. We hypothesize that local tissue strains can be determined from volumetric deformation. Volumetric deformation is defined as the amount of fluid displaced by the deformed heart valve leaflets in a stented configuration, and is measured, noninvasively, using a flow sensor. A numerical model is employed to relate volumetric deformation to local tissue strains in various regions of the leaflets (e.g. belly and commissures). The flow-based deformation measurement method was validated and its functionality was demonstrated in a tissue engineering experiment. Tri-leaflet, stented heart valves were cultured in vitro and during mechanical conditioning, realistic values for volumetric and local deformation were obtained.

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A numerical-experimental method for a mechanical characterization of biological materials

Cited by 53 publications

References 4 publications

Nonlinear elastic material property estimation of lower extremity residual limb tissues

Nonlinear elastic material property estimation of lower extremity residual limb tissues

Equi-Biaxial Tests for Mechanical Characterization of Human Acellular Dermal Matrices Through a Custom-Made Biaxial Fixture

Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

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