A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in atherosclerosis

Watt, Fiona M.; Rajendran, Reshmi; Ren, Minqin; Tan, B. T. G.; Halliwell, Barry

doi:10.1016/j.nimb.2006.03.073

Cited by 43 publications

(38 citation statements)

References 34 publications

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“…Increased lesional iron is also seen in cholesterol fed animals. In a series of studies with rabbits fed a 1% cholesterol diet, Watt and colleagues [70][71][72][73][74] used nuclear microscopy to show a 7-fold increase in iron concentration within newly formed atherosclerotic lesions compared to healthy arteries. Iron accumulation was seen at the onset of lesion formation.…”

Section: Discussionmentioning

confidence: 99%

Are Hemochromatosis Mutations Protective Against Iron-Mediated Atherogenesis?

Sullivan¹

2012

Atherogenesis

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Section: Discussionmentioning

confidence: 99%

Are Hemochromatosis Mutations Protective Against Iron-Mediated Atherogenesis?

Sullivan¹

2012

Atherogenesis

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“…На сегодняшний день в литературе значительное внимание уделяется металлам -цинку, железу, меди -содержащимся в стенках кровеносных сосудов, имеющих атеросклеротические повреждения. Так, для цинка установлена антиатерогенная роль [13,14,[27][28][29], а для железа и меди -проатерогенная [10,11,29]. Проатерогенная роль, возможно, связана с тем, что металлы с переменной валентностью могут участвовать в реакции Фентона [29].…”

Section: рисунокunclassified

“…Так, для цинка установлена антиатерогенная роль [13,14,[27][28][29], а для железа и меди -проатерогенная [10,11,29]. Проатерогенная роль, возможно, связана с тем, что металлы с переменной валентностью могут участвовать в реакции Фентона [29]. В наших экспериментах получены данные, убедительно свидетельствующие о возможности протекания реакции Фентона в образцах атеросклеротических бляшек (рис.…”

Section: рисунокunclassified

Manganese in atherogenesis: detection, origin, and role

et al. 2012

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The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis.

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“…Three scenarios are considered (i) a thin dehydrated and fixed cell typical of high resolution direct-STIM high resolution structural imaging [1,2]. (ii) 10-20 lm thick fixed and dried tissue section characteristic of micro-PIXE measurement of trace elements [23][24][25] and (iii) a 10 lm polymer window used for in-situ NM cell irradiation studies. 2 MeV protons and 4 He ions which are widely used for NM imaging were investigated in this study.…”

Section: Basic Considerationsmentioning

confidence: 99%