A novel way for analysis of calycosin via polyaniline functionalized graphene quantum dots fabricated electrochemical sensor

Cai, Jinying; Sun, Bolu; Gou, Xiaodan; Gou, Yuqiang; Wen, Li; Hu, Fangdi

doi:10.1016/j.jelechem.2018.03.035

Cited by 28 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be seen that the Raman signals of these binary hybrids are relatively suppressed in comparison with PC0, suggesting strong covalent interaction between PANI and N‐CDs. The characteristic peaks at 803, 1160, 1228, 1332, and 1595 cm −1 of PC0 corresponded to ring deformation of benzene/quinonoid rings, C─H bending of the quinonoid ring, C─N stretching of the benzenoid ring, and N─H bending of the bipolaronic structure, respectively . Obviously, the two characteristic peaks at 803 and 1480 cm −1 almost disappeared for N‐CDs@PANI hybrids especially PC4.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristic peaks at 803, 1160, 1228, 1332, and 1595 cm −1 of PC0 corresponded to ring deformation of benzene/quinonoid rings, C─H bending of the quinonoid ring, C─N stretching of the benzenoid ring, and N─H bending of the bipolaronic structure, respectively. 35,36 Obviously, the two characteristic peaks at 803 and 1480 cm −1 almost disappeared for N-CDs@PANI hybrids especially PC4. It may be derived by strong interactions between the N-CD surface and PANI polymer backbone.…”

Section: Morphology and Structure Characterizationmentioning

confidence: 99%

See 1 more Smart Citation

Morphology‐dependent electrochemical performance of nitrogen‐doped carbon dots@polyaniline hybrids for supercapacitors

et al. 2019

View full text Add to dashboard Cite

Summary In this work, the binary N‐CDs@PANI hybrids were fabricated by introducing zero‐dimensional nitrogen‐doped carbon dots (N‐CDs) into reticulated PANI. Firstly, N‐CDs were prepared by one‐pot microwave method, and then, the N‐CDs were introduced into in situ oxidative polymerization of aniline (ANI) monomer. The N‐CDs with abundant functional groups and high electronic cloud density played a significant role in guiding the polyaniline‐ordered growth into intriguing morphologies. Moreover, morphology‐dependent electrochemical performances of N‐CDs@PANI hybrids were investigated and N‐CDs improve static interaction and enhance the special capacitances in the N‐CDs@PANI hybrids. Especially, the specific capacitance of PC4 hybrid can reach 785 F g−1, which exceed that of pure PANI (274 F g−1) at current density of 0.5 A g−1 according to three‐electrode measurement. And the capacitance retention of the PC4 hybrid still keeps 70% after 2000 cycles of charge and discharge. The N‐CDs@PANI hybrids can have potential applications in electrode materials, supercapacitors, nonlinear optics, and microwave absorption.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Morphology and Structure Characterizationmentioning

confidence: 99%

Morphology‐dependent electrochemical performance of nitrogen‐doped carbon dots@polyaniline hybrids for supercapacitors

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Astragali Radix and Hedysari Radix have been shown to inhibit bone resorption, stimulate bone formation, and prevent ovariectomy induced osteoporosis (Wegiel and Persson, ; Choi et al, ; Zhao et al, ). Calycosin (C 16 H 12 O 5 ; Figure ) is the pharmacologically active flavonoid component of Astragali Radix and Hedysari Radix (Zhang et al, ; Cai et al, ). It has been reported that calycosin‐7‐O‐β‐D‐glucopyranoside inhibits osteoclast development in vitro and bone loss in vivo.…”

Section: Introductionmentioning

confidence: 99%

Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway

Fang

Xue

Zhao

et al. 2019

Cell Biology International

View full text Add to dashboard Cite

Calycosin has been reported to have a strong osteogenic activity and a positive correlation with anti‐osteoporosis effects. However, its precise mechanism of action remains unclear. Since insulin‐like growth factor 1 receptor (IGF1R) signaling and phosphatidylinositol 3‐kinase/Akt (PI3K/Akt) signaling have been shown to play a pivotal role in regulating osteogenesis, we hypothesized that the osteogenic activity of calycosin is mediated by these signaling pathways. Rat calvarial osteoblasts (ROBs) were cultured in osteogenic medium containing calycosin with or without GSK1904529A (GSK) or LY294002 (LY) (inhibitors of IGF1R and PI3K, respectively). The effects on cell proliferation, alkaline phosphatase (ALP) activity, calcified nodules, mRNA or protein expression of osteogenic genes [alkaline phosphatase (Alpl), collagen type I (Col1a1), runt‐related transcription factor 2 (Runx2), Osterix, and bone morphogenetic protein 2 (Bmp2)], and phosphorylation of IGF1R and Akt were examined. The present results showed that calycosin enhanced cell proliferation, ALP activity and Alizarin Red‐S staining in a dose‐dependent manner in the range of 10−8–10−6 M, while an inhibitory effect was observed at 10−5 M. Treatment at the optimal concentration (10−6 M, a physiologically achievable concentration) increased mRNA levels of osteogenic genes and phosphorylation of IGF1R and Akt. Furthermore, treatment with GSK or LY partly reversed the effects of calycosin on ROBs, as indicated by the decreases in calycosin‐induced ALP activity, calcified nodules and osteogenic gene expression. These results suggest that the osteogenic effect of calycosin partly involves the IGF1R/PI3K/Akt signaling pathway.

show abstract

“…The oxidation aspect of DB was approved by CV, where a linear response of DB concentration ranged between 0.08-40.0 µM, with an LOD of 0.02 µM. In 2018, Cai et al reported an electrochemical sensing technique for calycosin, a biomarker responsible for inflammation, diabetic cognitive impairment and cardiac diseases [282]. In this work, polyaniline functionalized GQDs were produced by following an in situ polymerization.…”

Section: Voltammetric Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

161

View full text Add to dashboard Cite

Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

show abstract

A novel way for analysis of calycosin via polyaniline functionalized graphene quantum dots fabricated electrochemical sensor

Cited by 28 publications

References 35 publications

Morphology‐dependent electrochemical performance of nitrogen‐doped carbon dots@polyaniline hybrids for supercapacitors

Morphology‐dependent electrochemical performance of nitrogen‐doped carbon dots@polyaniline hybrids for supercapacitors

Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway

Applications of Graphene Quantum Dots in Biomedical Sensors

Contact Info

Product

Resources

About