A novel visual ratiometric fluorescent sensing platform for highly-sensitive visual detection of tetracyclines by a lanthanide- functionalized palygorskite nanomaterial

Xu, Jun; Shen, Xiaoke; Jia, Lei; Zhou, Tao; Ma, Tieliang; Xu, Zhouqing; Cao, Jianliang; Zhang, Ge; Bi, Ning; Zhu, Tao; Guo, Shengli; Li, Xiaohui

doi:10.1016/j.jhazmat.2017.08.020

Cited by 121 publications

(32 citation statements)

References 35 publications

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“…However, traditional fluorometry usually measures the variation of one fluorescence signal, which is easily affected by probe concentration and environmental factors . Fortunately, a ratiometric fluorescence strategy can reduce or eliminate these interferences to achieve a more sensitive and reliable analysis because ratiometric fluorescence can offer intrinsic self-calibration for signals by simultaneously collecting the variation of two emission bands. − Lately, several interesting ratiometric fluorescence strategies have been designed for TC detection. − However, most of these ratiometric fluorescence strategies do not produce synchronous changes in the two fluorescence signals caused by TC or the two fluorescence colors have a small chroma difference, resulting in an unnoticeable fluorescence color variation, which greatly limits the ability of visual analysis. Accordingly, it is still highly desirable to design a valid ratiometric fluorescence strategy combining some common and portable devices, such as test paper and smartphones, for a quick and visual assay of TC on-site.…”

Section: Introductionmentioning

confidence: 99%

Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect

Han

Fan

Qing

et al. 2020

ACS Appl. Mater. Interfaces

120

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Development of selective and sensitive methods for on-site assay of tetracycline (TC) is of great significance for public health and food safety. Herein, a valid ratiometric fluorescence strategy using g-C 3 N 4 nanosheets coupled with Eu 3+ is designed for the assay of TC. In this strategy, both Eu 3+ and g-C 3 N 4 nanosheets serve as the recognition units of TC. The blue fluorescence of g-C 3 N 4 nanosheets can be quenched by TC via the inner filter effect (IFE); meanwhile, the red fluorescence of Eu 3+ can be enhanced by TC through the antenna effect (AE). The synergistic effect of AE and IFE caused by TC makes the developed ratiometric fluorescent sensor display a wide linear range for TC from 0.25 to 80 μM with a detection limit of 6.5 nM and a significant fluorescence color evolution from blue to red. Given its simplicity, free-label, excellent selectivity, high sensitivity, and recognizable color change, point-of-care testing systems, including smartphones and test paper-based assays, are developed for the visual sensing of TC. The integration of smartphones and test paper on a ratiometric fluorescent sensor greatly reduces the detection cost and time, providing a promising method for the qualitative discernment and semi-quantitative assay of TC on-site. Moreover, the potential application of the approach is also verified by detecting TC in milk.

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Section: Introductionmentioning

confidence: 99%

Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect

Han

Fan

Qing

et al. 2020

ACS Appl. Mater. Interfaces

120

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“…Meanwhile, the abuse of antibiotics also causes tetracycline residues in foods such as milk [6], meat [7], honey [8] and fish [9]. Excessive residual consumption or continual long-term intake with small doses of tetracycline can result in undesirable effects, such as gastrointestinal disturbance, anaphylactic reaction and hepatotoxicity, leading to a significant increase in antibiotic resistance of pathogenic microorganisms and a consequential increase in drug-resistant genes [10][11][12]. In the long term, the tetracycline will eventually enter the human body through the food chain and thus poses a serious threat to human health.…”

Section: Introductionmentioning

confidence: 99%

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

Zhao

et al. 2020

Molecules

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Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal–organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and removal of pollutants from complex matrices. Herein, a high-stable metal organic framework (MOF), i.e., ((ZnCl2)3(L)2·DMF)n, where L=1,3,5-tris((pyridin-4-ylthio)methyl)benzene), MOF 1, was applied to adsorb and remove tetracycline from sewage and dairy products. The results showed that MOF 1 exhibited a strong performance in the adsorption of tetracycline. The effects of initial pH values, adsorbent dose, contact time and ionic strength of the adsorption performance of MOF 1 were investigated. The adsorption kinetics best fit the pseudo-second order model, and the adsorption isotherms matched the Langmuir adsorption model well. It was indicated that both chemical adsorption and physical adsorption play an important role in the adsorption process, and the adsorption of tetracycline was homogeneous and occurred on a monolayer on the surface of MOF 1. Additionally, the stability of MOF 1 and the details of the adsorption mechanism were also investigated. Thus, this study provides a new candidate for the application of MOFs-based adsorbents in the removal of antibiotics from sewage and dairy products.

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“…Next, a multi-purpose silica shell was assembled for encapsulation of the internal standard. The silica shell not only effectively protected the dye molecules and reduced losses [30], but also provided the attachment of amino groups, which facilitated the grafting of europium complexes. Based on the above advantages, the fluorescent dye molecules were encapsulated into UiO-66 and covalently grafted with the europium complex, which can realize the multi-color fluorescent sensing of TC.…”

Section: Introductionmentioning

confidence: 99%

A Ratiometric Fluorescent Nano-Probe for Rapid and Specific Detection of Tetracycline Residues Based on a Dye-Doped Functionalized Nanoscaled Metal–Organic Framework

Jia

Guo

et al. 2019

Nanomaterials

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Tetracycline (TC) residues are harmful to the environment and human body, so it is necessary to develop a highly sensitive probe for rapid detection of tetracycline residues. In the present paper, a novel dye-doped porous metal–organic framework (UiO-66)-based multi-color fluorescent nano-probe was designed for sensitive ratiometric detection of tetracycline (TC). In this probe, dye-molecules doped UiO-66 was used as a fluorescent internal standard, and the externally grafted lanthanide Eu3+ complex was used as response signals. The fluorescence of the Eu3+ complex was selectively enhanced with increasing concentrations of TC, which was accompanied by a visual blue-to-red color switch. The nano-probe had a linear response between 0.1 and 6 μM with a lowest detection limit of 17.9 nM, which was much lower than the maximum residue limits set by the United States Food and Drug Administration (676 nM) and the European Union (225 nM). The applicability of this method in the analysis of actual samples was evaluated by the determination of TC in honey and milk samples, indicating satisfactory recovery and good reproducibility. In addition, a cost-effective paper-based probe for rapid and visual detection of TC was developed by fixing the nano-probe on filter papers. With the help of a smartphone camera to capture the fluorescence color, and chromaticity analysis software, the calculation and analysis of red (R) and blue (B) values can be realized, which has the potential for real-time visual detection of TC.

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A novel visual ratiometric fluorescent sensing platform for highly-sensitive visual detection of tetracyclines by a lanthanide- functionalized palygorskite nanomaterial

Cited by 121 publications

References 35 publications

Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect

Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

A Ratiometric Fluorescent Nano-Probe for Rapid and Specific Detection of Tetracycline Residues Based on a Dye-Doped Functionalized Nanoscaled Metal–Organic Framework

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