A novel view of the problem of Osteoarthritis in experimental rat model

Паликов, В. А.; Palikova, Yu. A.; Borozdina, N. A.; Nesmeyanova, Elena; Руденко, П. А.; Kazakov, Vitalij A.; Kalabina, E. A.; Bukatin, Mikhail V.; Zharmukhamedova, T. Yu.; Хохлова, О. Н.; Dyachenko, Igor A.

doi:10.3897/rrpharmacology.6.51772

Cited by 13 publications

(4 citation statements)

References 22 publications

(23 reference statements)

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“…Под воздействием ряда неблагоприятных факторов, неполноценного питания, нарушений элементарных ветеринарно-санитарных правил содержания, невыполнении мер по профилактике инфекционных болезней, нерациональной антибиотикотерапии может страдать иммунокомпетентная система, и, как следствие, возникают различные иммунодефицитные состояния [4][5][6]. В результате этого активизируется не только условно патогенная микрофлора, но даже и у сапрофитной микробиоты могут возникать факторы патогенности.…”

Section: терапия животныхunclassified

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

2022

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Relevance. Despite the constant improvement of methods for correcting the intestinal microbiota, the occurrence of dysbacteriosis in various pathological processes not only does not decrease, but, on the contrary, increases. Therefore, the choice of the optimal therapeutic regimen for the correction of the lightest compensated degree of intestinal dysbiosis in cats, in our opinion, is an urgent direction of scientific research in veterinary medicine.Methods. Evaluation of the effectiveness of pharmacotherapy in cats with compensated intestinal dysbiosis (n = 15) is given. The animals were divided by the envelope method into two experimental groups: A1 (n = 6) and A2 (n = 9). The dynamics of individual hematological and immunological blood parameters of cats with grade 1 dysbiosis in the course of their therapy (before treatment, on days 7 and 14) is shown.Results. With compensated intestinal dysbiosis in cats, the appointment of the Purina Pro Plan dietary food shows a therapeutic effect, which leads to an overall clinical improvement as early as after 6.16±0.60 days. However, the use of the probiotic «Lactobifadol» against the background of diet therapy normalizes appetite after 2.39 days, an unpleasant odor from the oral cavity after 0.84 days, feces after 0.89 days, accelerates the overall clinical improvement of animals with intestinal dysbiosis of the 1st degree by 2.16 days earlier, when compared with the indicators of cats of the A1 group.

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Section: терапия животныхunclassified

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

2022

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“…The optimization of veterinary services, the reduction of morbidity and mortality of animals, and the effective prevention and improvement of measures to combat various diseases play a decisive role in improving the quality of life of animals [1][2][3][4][5][6][7]. Recently, in cities, there has been a significant increase in the number of dogs and cats, which often become full-fledged family members.…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

et al. 2022

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Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose of the study was a detailed analysis of the quantitative and qualitative fecal microbiota spectrum in cats with intestinal dysbiosis of varying severity. The data obtained indicate that, depending on the dysbiosis severity in cats, the intestinal microbiome landscape changes significantly. It has been established that, depending on the dysbiosis severity, there is a shift in the balance between the Gram-positive and Gram-negative bacterial pools and in the nature of the isolation of specific bacteria forms, in the amount of obligate microbiota isolation, as well as individual facultative strains. When analyzing the serotyping of E. coli cultures isolated at various grades of intestinal dysbiosis severity, differences were found both in the isolation amount of various serotypes from one animal and in the prevalence of certain serotypes for each disease severity. A retrospective analysis of the fecal microbiota sensitivity in cats with dysbiosis to antibacterial drugs showed that, depending on the disease severity, the number of isolates sensitive to antibiotics increases significantly.

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“…Основная задача оптимизации ветеринарного обслуживания -снижение заболеваемости и падежа благодаря своевременной профилактике и совершенствованию мер борьбы с различными патологиями, а также корригирование благополучия и содержания животных, играющее решающую роль в улучшении качества их жизни [1][2][3][4][5]. Благополучие, рост и производительность животных модулируются условиями окружающей среды и условиями их содержания и могут существенно влиять на качество и количество животноводческой продукции.…”

Section: Introductionunclassified

Features of the functional state of the organism of sheep under stress

Yuldashbaev

Vatnikov

Руденко

et al. 2022

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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The stresses that arise during routine animal husbandry procedures, such as milking, shearing, weighing, loading and hoof care, are an actual problem in animal husbandry. The components of economic damage under stress are a decrease in overall resistance and productivity, deterioration in product quality, an increase in labor costs and funds per unit of production, an increase in animal morbidity and mortality. The studies were carried out on the basis of Belozernoe farm in the Salsky district, the Rostov region. A complex of clinical and laboratory studies was performed on 18 sheep (10 Romanov and 8 Tsigay breeds) aged 2 to 3 years, before and after a planned routine shearing. Stress in sheep caused by planned shearing was clinically manifested by general depression, in some cases, subfebrile fever, moderate tachypnea and tachycardia. It was shown that stress was accompanied by anemia, the development of erythropenia and leukopenia. Immunocompetent cells in the blood of experimental animals during stress development were analyzed. Severe lymphocytopenia was found to occur after a haircut. In addition, in the blood of experimental animals under stress, a tendency to a decrease in T-total cells was noted, which was accompanied by an increase in 0-cells, which was significant in sheep of the Tsigay breed (p0.05). When analyzing the main immunoregulatory T cells in sheep under stress, a significant increase in T-suppressors was revealed with a relatively stable level of T-helpers in the blood studied. Thus, a significant (p0.05) increase in the level of T-suppressors in sheep of Romanov and Tsigay breeds was recorded; it was by 1.15 and 1.19 times higher compared with the initial data. It should be noted that we did not find any significant differences between animals of Romanov and Tsigay breeds in stress development after shearing. The obtained data should be taken into account in the further search for methods of stress correction in sheep.

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A novel view of the problem of Osteoarthritis in experimental rat model

Cited by 13 publications

References 22 publications

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

Features of the functional state of the organism of sheep under stress

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