A novel treatment for keratitis sicca (Dry eye): Anatomical feasibility study

Iwanaga, Joe; Watanabe, Koichi; Kusukawa, Jingo; Fisahn, Christian; Alonso, Fernando; Oskouian, Rod J.; Tubbs, R. Shane

doi:10.1002/ca.22946

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…If the SON and STN pass through the bony foramen and/or notch bound by a distinct fibrous band [14,16,19], these structures might compress the nerve when the nerve transfer is attempted [16,19]. Accordingly, better anatomical knowledge of the SON and STN, as well as their related anatomical variation is essential to success of ipsilateral CN [20,21].…”

Section: Discussionmentioning

confidence: 99%

The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study

et al. 2020

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Neurotrophic keratitis is a rare corneal disease that is challenging to treat. Corneal neurotization (CN) is among the developing treatments that uses the supraorbital (SON) or supratrochlear (STN) nerve as a donor. Therefore, the goal of this study was to provide the detailed anatomy of these nerves and clarify their feasibility as donors for ipsilateral CN. Both sides of 10 fresh-frozen cadavers were used in this study, and the SON and STN were dissected using a microscope intra-and extraorbitally. The topographic data between the exit points of these nerves and the medial and lateral angle of the orbit were measured, and nerve rotation of these nerves toward the ipsilateral cornea were attempted. The SON and STN were found on 19 of 20 sides. The vertical and horizontal distances between the exit point of the SON and that of the STN, were 7.3±2.1 mm (vertical) and 4.5±2.3 mm, respectively. The mean linear distances between the medial angle and the exit points of each were 22.2±3.0 mm and 14.5±1.9 mm, respectively, and the mean linear distances between the lateral angle and the exit points of the SON and STN were 34.0±2.7 mm and 36.9±2.5 mm, respectively. These nerves rotated ipsilaterally toward the center of the orbit easily. A better understanding of the anatomy of these nerves can contribute to the development and improvement of ipsilateral CN.

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Section: Discussionmentioning

confidence: 99%

The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study

et al. 2020

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“…The ATN leaves the infratemporal fossa and innervates the parotid gland. In its ascent, the nerve travels closely with the superficial temporal artery and continues superior to the temporomandibular joint to give off communicating branches to the facial nerve [ 2 , 3 ]. Its terminal superficial temporal branches are variable in distribution [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nervous Interconnection Between the Lesser Occipital and Auriculotemporal Nerves

Gebara¹,

Iwanaga²,

Dumont³

et al. 2022

Cureus

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The auriculotemporal nerve is one branch of the mandibular portion of the trigeminal nerve, which itself divides into several branches in the temporal and retromandibular regions. The lesser occipital nerve is a cutaneous branch of the cervical plexus and is sometimes implicated in cases of cervicogenic headaches, occipitoparietal headaches, and occipital neuralgia, in general. Here, we present a case of unilateral neural interconnection between the auriculotemporal and lesser occipital nerves thus illustrating the joining of the cervical plexus and trigeminal nerve. A better understanding of the aforementioned nervous anatomy may be valuable for facial reconstructive and nerve transfer procedures, as well as for a variety of other head and neck disorders, e.g., occipital neuralgia.

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“… 3 Any defects in tear film quality will deteriorate corneal physiology, which ultimately can lead to opacification and white blindness. 4 – 7 …”

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confidence: 99%

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions

Willems

Wells

Coubes

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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As part of the lacrimal apparatus, the lacrimal gland participates in the maintenance of a healthy eye surface by producing the aqueous part of the tear film. Alacrimia and hypolacrimia, which are relatively rare during childhood or young adulthood, have their origin in a number of mechanisms which include agenesia, aplasia, hypoplasia, or incorrect maturation of the gland. Moreover, impaired innervation of the gland and/or the cornea and alterations of protein secretion pathways can lead to a defective tear film. In most conditions leading to alacrimia or hypolacrimia, however, the altered tear film is only one of numerous defects that arise and therefore is commonly disregarded. Here, we have systematically reviewed all of those genetic conditions or congenital disorders that have alacrimia or hypolacrimia as a feature. Where it is known, we describe the mechanism of the defect in question. It has been possible to clearly establish the physiopathology of only a minority of these conditions. As hypolacrimia and alacrimia are rare features, this review could be used as a tool in clinical genetics to perform a quick diagnosis, necessary for appropriate care and counseling.

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A novel treatment for keratitis sicca (Dry eye): Anatomical feasibility study

Cited by 5 publications

References 21 publications

The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study

The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study

Nervous Interconnection Between the Lesser Occipital and Auriculotemporal Nerves

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions

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