A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease

Talpos, John C.; Winters, Boyer D.; Dias, Rebecca; Saksida, Lisa M.; Bussey, Timothy J.

doi:10.1007/s00213-009-1526-3

Cited by 105 publications

(194 citation statements)

References 61 publications

(73 reference statements)

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“…dPAL has already been shown to be hippocampus dependent in rats and mice (Talpos et al 2009;Kim et al 2015). We found that the new protocol with overlearning did not affect the hippocampal dependency of this task.…”

Section: Discussionmentioning

confidence: 59%

“…The basic rules for these two tasks were the same as previously described (Talpos et al 2009). When mice touched a correct stimulus, they received the liquid reward, and an ITI (15 s) was introduced.…”

Section: Spal and Dpalmentioning

confidence: 99%

“…Two variants of the touchscreen PAL task, same PAL (sPAL) and different PAL (dPAL), have been developed recently to test object-location memory (Talpos et al 2009) and used widely in rodents. First, these tasks were applied in rats in some studies (Talpos et al 2014;Kumar et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…First, these tasks were applied in rats in some studies (Talpos et al 2014;Kumar et al 2015). The dPAL task was shown to be sensitive to pharmacological inhibition of hippocampal activity (Talpos et al 2009). In addition, this task was used to test the effect of antagonism of various Nmethyl-d-aspartate receptor subtypes in rats (Kumar et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Finally, we tested whether the PAL tasks with the new protocols are hippocampus dependent. The dPAL task has previously been shown to rely on hippocampal function in rats and mice (Talpos et al 2009;Kim et al 2015). By performing pharmacological experiments, we tested whether dPAL and sPAL with overlearning still require the function of the dorsal hippocampus (dHP), and the new 2-object sPAL task is also hippocampus dependent.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Kim

Kwak

et al. 2016

Animal Cells and Systems

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Two versions of the touchscreen paired-associate learning (PAL) task have been developed for rodents: same PAL (sPAL) and different PAL (dPAL). These tasks are very important in studying murine models of Alzheimer's disease and schizophrenia, and have also been used to test object-location memory in various studies. However, the relatively long time needed for the tasks (approx. 50 days for mice) limits their widespread use. By giving training that was more intensive with a higher number of trials, we shortened the time required for learning saturation in sPAL and dPAL to about one-third of the time required for the generally used protocol. Furthermore, by applying a reduced number of objects and trial types for sPAL, we developed a simplified version of sPAL, termed 2-object sPAL, in which mice could reach the fully learned level in 6 days. Our pharmacological experiments indicate that the dorsal hippocampal CA1 region is crucial for the performance of the two PAL tasks with the new protocols and the new 2-object sPAL. This work has significantly enhanced the usefulness of the touchscreen PAL tasks to increase the speed of learning, but they remain highly hippocampus-dependent objectlocation memory tasks. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 59%

Section: Spal and Dpalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Kim

Kwak

et al. 2016

Animal Cells and Systems

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Do the Cambridge Neuropsychological Test Automated Battery episodic memory measures discriminate amnestic mild cognitive impairment?

Juncos‐Rabadán

Pereiro

Facal

et al. 2013

Int J Geriat Psychiatry

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Rats use hippocampus to recognize positions of objects located in an inaccessible space

et al. 2012

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Rat hippocampus plays a crucial role in many spatial tasks, including recognition of position of objects, which can be approached and explored. Whether hippocampus is also necessary for recognizing positions of objects located in an inaccessible part of the environment remains unclear. To address this question, we conditioned rats to press a lever when an object displayed on a distant computer screen was in a particular position ("reward position") and not to press the lever when the object was in other positions ("nonreward positions"). After the rats had reached an asymptotic performance, the role of the dorsal hippocampus was assessed by blocking its activity with muscimol. The rats without functional dorsal hippocampus did not discriminate the reward position from the nonreward positions. Then the same rats were trained to discriminate light and dark conditions. The hippocampal inactivation did not disrupt the ability to discriminate these two conditions. It indicated that the inactivation itself had no major effect on the operant behavior and its control by visual stimuli. We conclude that rats use dorsal hippocampus for recognizing positions of objects located in an inaccessible part of the environment.

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A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease

Cited by 105 publications

References 61 publications

Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Do the Cambridge Neuropsychological Test Automated Battery episodic memory measures discriminate amnestic mild cognitive impairment?

Rats use hippocampus to recognize positions of objects located in an inaccessible space

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