Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Kim, Myeongwon; Kwak, Chuljung; Yu, Nam-Kyung; Kaang, Bong‐Kiun

doi:10.1080/19768354.2016.1221855

Cited by 8 publications

(22 citation statements)

References 25 publications

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“…While the "flower-plane-spider" set of stimuli was the one routinely used in dPAL at the time the here-reported experiments were conducted (e.g. (Bartko et al, 2011;M. Kim et al, 2016;Talpos et al, 2009); Fig.…”

Section: Discussionmentioning

confidence: 99%

“…hippocampus-based spatial learning and/or striatum-based stimulus-response learning (Delotterie et al, 2015;C. H. Kim et al, 2015;M. Kim et al, 2016;Talpos et al, 2009); compare below).…”

Section: Discussionmentioning

confidence: 99%

“…However, a dissociation between two possible learning strategies in dPAL has also been proposed for mice and rats, based on pharmacologic and exitotoxic lesioning studies conducted in these species ((Delotterie et al, 2015;C. H. Kim et al, 2015;M. Kim et al, 2016;Talpos et al, 2009); compare below).…”

Section: Discussionmentioning

confidence: 99%

“…The most likely explanation for the fact that post-acquisition lesioning of the dorsal hippocampus robustly affects dPAL performance in rodents (Delotterie et al, 2015;C. H. Kim et al, 2015;M. Kim et al, 2016;Talpos et al, 2009) while acquisition is not (Delotterie et al, 2015;Talpos et al, 2009) or only mildly (C. H. Kim et al, 2015) affected by hippocampus lesions is that intact animals acquire the task in a hippocampus-dependent manner (hence the profound effect of post-acquisition lesioning) but switch to alternative (equally effective) learning strategies (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…(Delotterie et al, 2015;C. H. Kim, Heath, Kent, Bussey, & Saksida, 2015;M. Kim, Kwak, Yu, & Kaang, 2016;Talpos et al, 2009)).…”

Section: Introductionmentioning

confidence: 99%

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First comparative approach to touchscreen-based visual object–location paired-associates learning in humans (Homo sapiens) and a nonhuman primate (Microcebus murinus).

Schmidtke¹,

Ammersdörfer²,

Joly³

et al. 2018

Journal of Comparative Psychology

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A recent study suggests that a specific, touchscreen-based task on visual object-location paired-associates learning (PAL), the so-called Different PAL (dPAL) task, allows effective translation from animal models to humans. Here, we adapted the task to a nonhuman primate (NHP), the gray mouse lemur, and provide first evidence for the successful comparative application of the task to humans and NHPs. Young human adults reach the learning criterion after considerably less sessions (one order of magnitude) than young, adult NHPs, which is likely due to faster and voluntary rejection of ineffective learning strategies in humans and almost immediate rule generalization. At criterion, however, all human subjects solved the task by either applying a visuospatial rule or, more rarely, by memorizing all possible stimulus combinations and responding correctly based on global visual information. An error-profile analysis in humans and NHPs suggests that successful learning in NHPs is comparably based either on the formation of visuospatial associative links or on more reflexive, visually guided stimulus-response learning. The classification in the NHPs is further supported by an analysis of the individual response latencies, which are considerably higher in NHPs classified as spatial learners. Our results, therefore, support the high translational potential of the standardized, touchscreen-based dPAL task by providing first empirical and comparable evidence for two different cognitive processes underlying dPAL performance in primates. (PsycINFO Database Record

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Section: Discussionmentioning

confidence: 99%

“…hippocampus-based spatial learning and/or striatum-based stimulus-response learning (Delotterie et al, 2015;C. H. Kim et al, 2015;M. Kim et al, 2016;Talpos et al, 2009); compare below).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…(Delotterie et al, 2015;C. H. Kim, Heath, Kent, Bussey, & Saksida, 2015;M. Kim, Kwak, Yu, & Kaang, 2016;Talpos et al, 2009)).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

First comparative approach to touchscreen-based visual object–location paired-associates learning in humans (Homo sapiens) and a nonhuman primate (Microcebus murinus).

Schmidtke¹,

Ammersdörfer²,

Joly³

et al. 2018

Journal of Comparative Psychology

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Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits After Central Nervous System Injury

Cotter

Bancroft

Haas

et al. 2023

Methods in Molecular Biology

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Cognitive behavioral markers of neurodevelopmental trajectories in rodents

et al. 2021

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Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also represents a vulnerable period for the onset of symptoms in neurodevelopmental psychiatric disorders. Despite the wide use of rodent models to unravel neurobiological mechanisms underlying neurodevelopmental disorders, there is a surprising paucity of rigorous studies focusing on normal cognitive-developmental trajectories in such models. Here, we sought to behaviorally capture maturational changes in cognitive trajectories during adolescence and into adulthood in male and female mice using distinct behavioral paradigms. C57 BL/6J mice (4.5, 6, and 12 weeks of age) were assessed on three behavioral paradigms: drug-induced locomotor hyperactivity, prepulse inhibition, and a novel validated version of a visuospatial paired-associate learning touchscreen task. We show that the normal maturational trajectories of behavioral performance on these paradigms are dissociable. Responses in drug-induced locomotor hyperactivity and prepulse inhibition both displayed a ‘U-shaped’ developmental trajectory; lower during mid-adolescence relative to early adolescence and adulthood. In contrast, visuospatial learning and memory, memory retention, and response times indicative of motivational processing progressively improved with age. Our study offers a framework to investigate how insults at different developmental stages might perturb normal trajectories in cognitive development. We provide a brain maturational approach to understand resilience factors of brain plasticity in the face of adversity and to examine pharmacological and non-pharmacological interventions directed at ameliorating or rescuing perturbed trajectories in neurodevelopmental and neuropsychiatric disorders.

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Optimization of the touchscreen paired-associate learning (PAL) task for mice and its dorsal hippocampal dependency

Cited by 8 publications

References 25 publications

First comparative approach to touchscreen-based visual object–location paired-associates learning in humans (Homo sapiens) and a nonhuman primate (Microcebus murinus).

First comparative approach to touchscreen-based visual object–location paired-associates learning in humans (Homo sapiens) and a nonhuman primate (Microcebus murinus).

Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits After Central Nervous System Injury

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

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