A Novel Tool for the Assessment Oxidative Stress in Age-Related Macular Degeneration: Thiol/Disulfide Homeostasis Revisited

Yorgun, Mücella Arıkan; Toklu, Yasin; Altınkaynak, Hasan; Tanriverdi, Burak; Ergin, Merve; Bıçer, Cemile

doi:10.3109/02713683.2016.1141965

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Native thiol and TT levels were found to be lower in central serous chorioretinopathy and macular degeneration patients compared to control subject [79][80][81].…”

Section: Ophthalmic Disordersmentioning

confidence: 75%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…Native thiol and TT levels were found to be lower in central serous chorioretinopathy and macular degeneration patients compared to control subject [79][80][81].…”

Section: Ophthalmic Disordersmentioning

confidence: 75%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…Patients with AMD had significantly lower plasma levels of thiol and native thiol/disulfide ratios (TDRs) compared to those of healthy controls. The plasma native TDR decreased in accordance with the increasing severity of AMD [169].…”

Section: Serummentioning

confidence: 80%

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Hsueh

Chen

Tsao

et al. 2022

IJMS

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Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.

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“…The role of oxidative stress in pathogenesis of various ocular disease including the cataracts, age related macular degeneration, central serous chorioretinopathy, pterygium, dry eye and the keratoconus were reported before. 3,[12][13][14][15][16][17][18] Altınisik and et al showed increased oxidative stress index (OSI) and lower total antioxidant status (TAS) in the humor aqueous samples of the retinal vein occlusion patients and they blamed hypoxia, ischemia and reperfusion damage by the reactive oxygen radicals. 3 Becatti et al found higher reactive oxygen species production and membrane lipid peroxidation in the erythrocytes of the retinal vein occlusion patients due to the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfifide Homeostasis Which is an Oxidative Stress Indicator?

Polat¹,

Kurt²,

Kılıç³

et al. 2019

Turkiye Klinikleri J Ophthalmol

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In this study, it is aimed to investigate the dynamic thiol-disulfide homeostasis which is an indicator of oxidative stress in retinal vein occlusion patients. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Thirty nine retinal vein occlusion patients and 38 age-gender matched control subjects were included in the study. Exclusion criteria for retinal vein occlusion group were: ocular history and symptoms exceeding 3 weeks, any other history of ocular disease except the retinal vein occlusion, any previous ocular surgeries or lasers, any previous treatment or intra-vitreal injection for the retinal vein occlusion, any other systemic disease except the arterial hypertension. The control group included patients without any ocular or systemic diseases. Native thiol, total thiol, disulfide levels were studied in the serum samples of all participants and native/total thiol and disulfide/total thiol ratios were calculated as percentage. R Re es su ul lt ts s: : Total thiol, native thiol, disulfide, native/total thiol and disulfide/total thiol ratio were not significantly different between the retinal vein occlusion and the control groups. In the control group, age was inversely correlated with the total thiol level, but not with the other serum parameters. In the retinal vein occlusion group, there was no correlation among the age and the serum parameters but the body mass index (BMI) was inversely correlated with the total thiol level. C Co on nc cl lu us si io on n: : There was not any significant difference between the retinal vein occlusion patients and the control subjects for the thiol-disulfide homeostasis. K Ke ey yw wo or rd ds s: : Retinal vein occlusion; thiol-disulfide homeostasis; thiol; disulfide Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada retinal ven tıkanıklığı ile bir oksidatif stres belirteci olan dinamik tiyol-disülfit dengesi arasındaki ilişkinin araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Otuz dokuz retinal ven tıkanıklığı hastası ve 38 yaş ve cinsiyet eşleştirilmiş kontrol birey olmak üzere toplam 77 katılımcı çalışmaya alınmıştır. Retinal ven tıkanıklığı grubu için çalışmadan dışlanma kriterleri: 3 haftayı aşan göz şikayet ve bulguları, retinal ven tıkanıklığı dışında başka oküler hastalık öyküsünün olması, daha önce oküler cerrahi ve lazer öyküsünün olması, retinal ven tıkanıklığı için daha önce intravitreal enjeksiyon dahil olmak üzere herhangi bir tedavi uygulanmış olması, arteryel hipertansiyon dışında sistemik hastalık öyküsünün olması olarak belirlenmiştir. Kontrol grubu sistemik ve oküler hastalığı olmayan katılımcılardı. Native tiyol, total thiol, disülfit düzeyleri katılımcıların kan serumu örneklerinde çalışılarak belirlenmiştir ve native/total tiyol ve disülfit/total tiyol oranları hesaplanarak yüzde olarak kaydedilmiştir. B Bu ul lg gu u-l la ar r: : Total tiyol, native tiyol, disülfit, native/total tiyol oranı ve disülfit/total tiyol oranları retinal ven tıkanıklığı ve kontrol grubu arasında karşılaştırıldığında anlamlı fark bulunmamış...

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A Novel Tool for the Assessment Oxidative Stress in Age-Related Macular Degeneration: Thiol/Disulfide Homeostasis Revisited

Cited by 11 publications

References 24 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfifide Homeostasis Which is an Oxidative Stress Indicator?

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