A novel thermo-pneumatic peristaltic micropump with low temperature elevation on working fluid

Chia, Bonnie Tingting; Liao, Hsin-Hung; Yang, Yao‐Joe

doi:10.1016/j.sna.2010.02.018

Cited by 56 publications

(30 citation statements)

References 21 publications

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“…The simulated behavior of the micropump, shown in Fig. 4, is consistent with qualitative trends reported in the literature [6,9,26,[34][35][36][37][38][39][40]. In addition, Nabavi [9], Hwang [39], and Sheen [40] suggested an increase in the net flow rate of the micropump as the operating frequency increased, until a cut-off frequency is reached, L .…”

Section: Simulation Results and Discussionsupporting

confidence: 86%

Understanding frequency response of thermal micropumps using electrical network analogy

Bardaweel

2014

Can. J. Phys.

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In this article the frequency response of a thermal micropump is investigated using electrical network analogy modeling technique. This technique is based on dividing the micropump into subsystems and representing each subsystem using the equivalent network analogy. Obtained mathematical models of subsystems are then represented using transfer functions and block diagrams. As an example, thermopneumatic micropump is considered. Model simulation suggests an increase in the net flow rates of the micropump as the operating frequencies increased, until a first cut-off frequency is reached. A second cut-off frequency is observed with further increase in operating frequencies. Model simulations are consistent with qualitative experimental trends reported in the literature. The model is used to obtain a relationship between cut-off frequencies and design properties of the micropump. Model simulations show that lower cut-off frequency is related to mechanical properties of the thermopneumatic micropump, including stiffness and damping. Upper cut-off frequency is related to thermal properties of the thermopneumatic micropump, including thermal conductivity, heat capacity, and working fluid density.Résumé : Nous étudions ici la réponse en fréquence d'une micro-pompe thermique en utilisant une technique de modélisation par réseau électrique analogue. Selon cette technique, nous divisons la micro-pompe en sous-systèmes et chaque sous-système est représenté par un réseau analogue. La modélisation mathématique fait alors appel à des fonctions de transfert et à des schémas fonctionnels. Pour fin d'exemple, nous étudions une micro-pompe thermo-pneumatique. La modélisation suggère une augmentation du débit avec la fréquence jusqu'à une première fréquence de coupure. Une augmentation subséquente de la fréquence nous amène à une seconde fréquence de coupure. Ces simulations sont cohérentes avec les tendances qualitatives expérimentales rapportées dans la littérature. Nous utilisons le modèle pour obtenir la relation entre les fréquences de coupure et le design de la micro-pompe. Les simulations montrent que la fréquence de coupure la plus basse est reliée aux propriétés mécaniques de la micro-pompe thermo-pneumatique, incluant la rigidité et l'amortissement. La fréquence supérieure est reliée aux propriétés thermiques de la micro-pompe, incluant la conductivité thermique, la capacité calorifique et la densité du fluide pompé. [Traduit par la Rédaction]

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Section: Simulation Results and Discussionsupporting

confidence: 86%

Understanding frequency response of thermal micropumps using electrical network analogy

Bardaweel

2014

Can. J. Phys.

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“…Reported micropumps can be classified into two main categories: mechanical micropumps and non-mechanical micropumps. Mechanical micropumps contain moving parts and utilize piezoelectric (Hsu and Le 2009), electrostatic (Bertarelli et al 2011), thermo-pneumatic (Chia et al 2011), pneumatic (Yang et al 2009), optical (Maruo et al 2009) or acoustic (Nguyen et al 2000;Wang et al 2010) to drive the moving parts. These micropumps are still not scalable to achieve portability and miniaturization due to their limits, such as relying on external power supplies or specialized equipments, pulsatile flow, complicated system design, as well as expensive fabrication process (Good et al 2006;Zhang et al 2007;Woias 2005).…”

Section: Introductionmentioning

confidence: 99%

A micropump based on water potential difference in plants

Liu

Zhang

et al. 2011

Microfluid Nanofluid

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In land plants, water vapor diffuses into the air through the stomata. The loss of water vapor creates a water potential difference between the leaf and the soil, which draws the water upward. Quantitatively, the water potential difference is 1-2 MPa which can support a water column of 100-200 m. Here we present the design and operation of a biomimetic micropump. The micropump is mainly composed of a 48-lm thick metal screen plate with a group of 102-lm diameter micropores and an agarose gel sheet with nanopores of 100 nm diameter. The micropores in the screen plate imitate the stomata to regulate the flow rate of the micropump. The agarose gel sheet is used to imitate the mesophyll cells around the stomata. The lost of water from the nanopores in the gel sheet can generate a water potential difference (more than 30 kPa) which can drive solution flow in a microfluidic chip. Results have shown that a precise flow rate of 4-8 nl/min can be obtained by using this micropump, and its ultra-high flow rate is 113-126 nl/min. The advantages of this biomimetic micropump include adjustable flow rate, simple structure and low fabrication cost. It can be used as a ''plug and play'' fluid-driven unit in microfluidic chips without any external power sources or equipments.

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“…As shown in the cross-sectional views in Figure 2(a), when the heater beneath the AH chamber turns on, the temperature of the air in the AH chamber rises. Then, the air pressure inside the chamber increases and the air volume expands, which in turn gives rise to the upward deformation of the diaphragm on the top of the FV chamber 24 . Consequently, the deformed diaphragm isolates the two neighboring reaction zones.…”

Section: Resultsmentioning

confidence: 99%

An electromagnetically-driven microfluidic platform with indirect-heating thermo-pneumatic valves

et al. 2011

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In this work, we present a microfluidic platform which is capable of carrying out a series of laboratorial operations on a disposable chip. The platform employs coil arrays to transport biological samples attached on magnetic beads through different reaction zones in aqueous solutions. Micromachined thermopneumatic valves are adopted as the interfaces between sequential reactions. The self-contained system is composed of a disposable microfluidic reaction (MFR) chip and a fluidic driving/sensing (FDS) module. Various reaction zones with different functionalities are implemented on the MFR chip. Arrays of coils and micromachined heater/sensing chips are integrated into the FDS module. Also, novel indirect-heating thermo-pneumatic valves (IH-TPVs), which are monolithically integrated into the disposable MFR chip, are proposed and characterized. With an applied voltage of 3.2 V, the IH-TPV effectively isolates two adjacent reaction zones, while its temperature elevation is sufficiently low for biological samples and reagents. By employing the proposed approach, we design and implement a miniaturized biochip system which carries out the processes of DNA extraction, purification and amplification from whole blood sample. The dimension of the fully-integrated system is 72 mm×54 mm×11 mm, and the system could be fully operated with a 12 V DC power supply. DNA extraction and purification from human whole blood followed by PCR amplification for the 122 bp segment is successfully performed by using the system.

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A novel thermo-pneumatic peristaltic micropump with low temperature elevation on working fluid

Cited by 56 publications

References 21 publications

Understanding frequency response of thermal micropumps using electrical network analogy

Understanding frequency response of thermal micropumps using electrical network analogy

A micropump based on water potential difference in plants

An electromagnetically-driven microfluidic platform with indirect-heating thermo-pneumatic valves

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