A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways

Xu, Da; Zhang, Kun; Zhang, Zai Jun; Sun, Ye; Guo, Bao Jian; Wang, Yu Qiang; Hoi, Maggie Pui Man; Han, Yifan; Lee, Simon Ming‐Yuen

doi:10.1016/j.neuint.2014.09.001

Cited by 27 publications

(18 citation statements)

References 48 publications

(47 reference statements)

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“…1b). TN-2 was armed with two powerful free radical-scavenging nitrone moieties and showed remarkable activity protecting neuronal cells from oxidative injury in vitro (Xu et al 2014a) and ischemic stroke injury (Sun et al 2012) and also neurodegenerative diseases in animal models (Xu et al 2014c).…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: TN-2 Ameliorates Tunicamycin-Induced Mitochondria and Endoplasmic Reticulum Stress-Associated Apoptosis in Rat Dorsal Root Ganglion Neurons

Deng

Wang

et al. 2015

J Mol Neurosci

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: TN-2 Ameliorates Tunicamycin-Induced Mitochondria and Endoplasmic Reticulum Stress-Associated Apoptosis in Rat Dorsal Root Ganglion Neurons

Deng

Wang

et al. 2015

J Mol Neurosci

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“…We purchased LPS from Sigma-Aldrich Co (St. Louis, MO). The choice of TN-2 concentrations was based on previous studies [16][17][18][19] and the present study of MTT assay.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies have showed that TN-2 protected neuronal cells from 6-OHDA-or MPTP/MPP ? -induced neurotoxicity and NF-jB-mediated neuro-inflammation [16][17][18][19]. Despite evidence indicating the neuroprotective effect of TN-2, there is a lack of data describing the role of TN-2 in intrarenal inflammation.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: TN-2 modulates LPS-induced inflammatory response in human renal tubular epithelial cells by blocking TLR4-mediated NF-κB activation via MyD88- and TRIF-dependent mechanism

Liu

Zhang

et al. 2015

Inflamm. Res.

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“…Furthermore, TBN protected and rescued dopaminergic neurons from 1-methyl-4-phenylpyridinium- (MPP + -) and methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) or 6-hydroxyldopamine- (6-OHDA-) induced damage in vitro and in vivo models of Parkinson's disease (PD) by the reduction of oxidative stress plus increased cellular antioxidative defense capacities [72]. TN-2, which has two nitrone moieties, also exhibited potent neuroprotective effects against 6-OHDA-induced neurotoxicity and MPTP/MPP + -induced dopaminergic neurons damage [73, 74]. Another derivative of TMP, known as T-006 (Figure 2), protected primary cortical neurons from neurotoxicity as well as improvement in memory deficits in APP/PS1 transgenic mice [75].…”

Section: Therapeutic Implications For Vci With Traditional Chinesementioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer's disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

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A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways

Cited by 27 publications

References 48 publications

RETRACTED ARTICLE: TN-2 Ameliorates Tunicamycin-Induced Mitochondria and Endoplasmic Reticulum Stress-Associated Apoptosis in Rat Dorsal Root Ganglion Neurons

RETRACTED ARTICLE: TN-2 Ameliorates Tunicamycin-Induced Mitochondria and Endoplasmic Reticulum Stress-Associated Apoptosis in Rat Dorsal Root Ganglion Neurons

RETRACTED ARTICLE: TN-2 modulates LPS-induced inflammatory response in human renal tubular epithelial cells by blocking TLR4-mediated NF-κB activation via MyD88- and TRIF-dependent mechanism

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

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