Test sequencing for binary systems is a nondeterministic polynomial-complete problem, where greedy algorithms have been proposed to find the solution. The traditional greedy algorithms only extract a single kind of information from the D-matrix to search the optimal test sequence, so their application scope is limited. In this study, two novel greedy algorithms that combine the weight index for fault detection with the information entropy are introduced for this problem, which are defined as the Mix1 algorithm and the Mix2 algorithm. First, the application scope for the traditional greedy algorithms is demonstrated in detail by stochastic simulation experiments. Second, two new heuristic formulas are presented, and their scale factors are determined. Third, an example is used to show how the two new algorithms work, and four real-world D-matrices are employed to validate their universality and stability. Finally, the application scope of the Mix1 and Mix2 algorithms is determined based on stochastic simulation experiments, and the two greedy algorithms are also used to improve a multistep look-ahead heuristic algorithm. The Mix1 and Mix2 algorithms can obtain good results in a reasonable time and have a wide application scope, which also can be used to improve the multistep look-ahead heuristic algorithm.