A Novel Synthesis of Some New Pyrimidine and Thiazolopyrimidine Derivatives for Anticancer Evaluation

One-Pot Regioselective Synthesis of 5-Amino-3-Benzyl-7H-[1,3]Thiazolo[3,2-A]Pyrimidin-7-Ones via Sonogashira Coupling Reaction

“…6 Thiazolopyrimidines have been of interest due to their ability to inhibit 2-methylerythritol-2,4-cyclodiphosphate synthase. 7 They have been also used as analgesic and anti-Parkinsonian agents, 8 modulators of transient receptor potential vanilloid receptor 1 (TRPV1), 9 anti-cancer agents, [10][11][12] pesticides, 13 phosphatase inhibitors, 14,15 acetylcholinesterase inhibitors, 16 and anti-microbial substances. [17][18][19] The Sonogashira reaction is one of the most widely used C-C bond formation ones.…”

Benzo[h]thiazolo[2,3-b]quinazolines by an efficient p-toluenesulfonic acid-catalyzed one-pot two-step tandem reaction

“…In recent years, increasing interest has been focused on synthesis of thiazolopyrimidine and thiazoloquinazoline derivatives owing to their significant biological activities that include antimicrobial [1,2], antiviral [3], antioxidant [4], anticancer [5], antiinflammatory [6], antihypertensive [7], antiparkinsonian [8], anti-human immunodeficiency virus (HIV) [9], and antibiofilm [10] properties. They have also been reported as calcium antagonists [11], group 2 metabotropic glutamate receptor antagonists [12], 5-HT2 receptor antagonists [13,14], and inhibitors of enzymes such as xanthine oxidase [15], acetylcholinesterase [16], and CDC25B phosphatise [17].…”

An Efficient Synthesis of Benzothieno-[3',2': 2,3]pyrido[4,5-d]thiazolo[3,2-a]pyrimidin-5-ones

“…其 中, 含有噻唑并嘧啶骨架结构的噻唑并[3,2-a]嘧啶类化 合物由于其结构的多样性及表现出的多种生物活性和 药理活性, 如抗癌 [2] 、抗炎 [3] 、抗病毒 [4] 、镇痛 [5] 等, 近 年来引起极大的关注 [6] .…”