A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid):

Enhanced angiogenesis of growth factor-free porous biodegradable adhesive made with hexanoyl group-modified gelatin

“…Gecko feet [4] have been reported to adhere to tissue/ organ surfaces with fibrous structures exhibiting strong bonding ability on solid substrates. Naturally derived polymers including gelatin [5], alginate [6], and albumin [7,8] have been employed as basic components of tissue adhesive materials.…”

Sealants (Adhesives) to Prevent Bleeding

“…To eliminate the use of WSC, a glue composed of N -hydroxysuccinimide (NHS)-activated PLGA and gelatin was developed [ 91 ] . The NHS-activated PLGA could be stored for an extended period of time under dry, cool conditions without losing cross-linking ability.…”

Bonding of soft tissues using a novel tissue adhesive consisting of a citric acid derivative and collagen

“…Bonding strength to tissues was measured by following the procedures reported by Iwata et al [8] using tissue from the porcine thigh (2Â6 cm). We first applied 200 AL of tissue adhesive (CAD-C) at different CAD and collagen concentrations to one side of the tissue.…”

“…Fibrin glue is biocompatible with the human body and promotes wound healing; however, its low bonding strength to tissue limits its clinical use. Furthermore, some virus infections have been pointed out for usefulness of fibrin glue [8]. To adhere tissue to adhere with high bonding strength and low toxicity, researchers have developed tissue adhesives [9] using cross-linking reagents such as genipin [10], diepoxy compounds [11], and carbodiimide [12].…”