Bonding of soft tissues using a novel tissue adhesive consisting of a citric acid derivative and collagen

Taguchi, Tetsushi; Saito, Hirofumi; Uchida, Yoshiyuki; Sakane, Masataka; Kobayashi, Haruo; Kataoka, Kazunori; Tanaka, Junzo

doi:10.1016/j.msec.2004.08.037

Cited by 63 publications

(39 citation statements)

References 13 publications

(12 reference statements)

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“…As it is a derivative of citrate, which exists in the human body, it provides high bonding strength, biocompatibility and low toxicity [7,8]. In our in vivo experiment using Japanese white rabbits, no inflammation was observed in the knee joint at 3 months after operation.…”

Section: Discussionmentioning

confidence: 68%

“…When DST and HSA are blended, the amino group of HSA and carboxylate ester of DST make an amide bond, and gelation occurs. When this blended adhesive is placed in collagen, amide bonding occurs with the amine in collagen, and results in crosslinking of collagens and biological bonding [7,8,14].…”

Section: Discussionmentioning

confidence: 99%

“…Taguchi et al applied all these adhesives to subcutaneous tissue of rats, and observed inflammation for aldehyde-based and fibrin-based adhesives, but not for the DST-HSA adhesive. Also, the DST-HSA adhesive was biologically fully absorbed within 6 weeks after use [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…They reported excellent bonding strength, reactivity and bonding time when using disuccinimidyl tartrate (DST) as a crosslinker and human serum albumin (HSA) as a hardener for the muscle of porcine, with the bonding strength being equivalent to that of cyanoacrylate-based adhesive [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone

Inoue

Taguchi

Imade

et al. 2012

Science and Technology of Advanced Materials

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We have investigated the effectiveness and safety of a newly developed biological adhesive for repair of meniscal tear. The adhesive was composed of disuccinimidyl tartrate (DST) as a crosslinker and human serum albumin (HSA) as a hardener. To determine adequate concentration, bonding strength was measured using a tensiometer 5 min after applying the adhesive on the avascular zone tear of porcine meniscus; it was compared with the strengths of commercially available cyanoacrylate-based and fibrin-based adhesives. In vivo examination was performed using Japanese white rabbits, creating longitudinal tears on the avascular zone of meniscus and applying DST-HSA adhesive. Three months after operation the rabbits were sacrificed and tension test and histological evaluation were performed. Bonding strength was measured in three porcine meniscus groups: (i) only suturing, (ii) suturing after applying the adhesive on surface and (iii) suturing using an adhesive-soaked suture. The optimum concentrations were 0.1 mmol of DST and 42 w/v% of HAS. Bonding strength was greatest with cyanoacrylate-based adhesive, followed by DST-HSA adhesive, and fibrin-based adhesive. No inflammation was observed in the synovium or surrounding tissues 3 months after using the DST-HSA adhesive. Bonding strength was greatest with DST-HSA adhesive-soaked suturing group (77 ± 6 N), followed by suturing only group (61 ± 5 N) and surface adhesive application group (60 ± 8 N). The newly developed DST-HSA adhesive is considered safe and may be effective in enforcement of bonding of avascular zone tear of the meniscus.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone

Inoue

Taguchi

Imade

et al. 2012

Science and Technology of Advanced Materials

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“…Recently, we have developed novel crosslinkers, organic acids with active ester groups, for use in biocompatible medical devices [12,13]. These crosslinkers, made of citric acid, maleic acid and tartaric acids, were reported to form biopolymer matrices as a result of the reaction between amino groups of the biopolymer and active ester groups of crosslinkers [14][15][16]. The resulting matrices exhibit excellent cytocompatibility compared with commercially available crosslinkers such as glutaraldehyde [17,18].…”

Section: Introductionmentioning

confidence: 99%

Tamibarotene-loaded citric acid-crosslinked alkali-treated collagen matrix as a coating material for a drug-eluting stent

Inoue

Takayanagi

Fujiu

et al. 2012

Science and Technology of Advanced Materials

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Tamibarotene-loaded biodegradable matrices with antithrombogenic and drug-releasing properties were prepared in a crosslinking reaction between amino groups of alkali-treated collagen (AlCol) and active ester groups of trisuccinimidyl citrate. The resulting matrices were characterized by their residual amino group concentrations, swelling ratios and thermal, antithrombogenic and drug-releasing properties. It was clarified that the addition of tamibarotene does not inhibit matrix formation. After immersion in water, the swelling ratio of a matrix became lower than that prior to immersion. Thermal analysis indicated that AlCol interacted with tamibarotene. The addition of tamibarotene to the matrix did not influence the antithrombogenic property of the resulting matrix. A matrix with a high crosslinking density had a prolonged tamibarotene elution time. These results demonstrate that tamibarotene-loaded matrices have great potential as a coating material for drug-eluting stents.

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Fish Collagen

Benjakul

Nalinanon

Shahidi

2012

Food Biochemistry and Food Processing

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Bonding of soft tissues using a novel tissue adhesive consisting of a citric acid derivative and collagen

Cited by 63 publications

References 13 publications

Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone

Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone

Tamibarotene-loaded citric acid-crosslinked alkali-treated collagen matrix as a coating material for a drug-eluting stent

Fish Collagen

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