A Novel Superdisintegrating Agent Made from Physically Modified Chitosan with Silicon Dioxide

El‐Barghouthi, Musa I.; Eftaiha, Ala’a F.; Rashid, Iyad; Al-Remawi, Mayyas; Badwan, Adnan A.

doi:10.1080/03639040701657792

Cited by 71 publications

(45 citation statements)

References 27 publications

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“…MCC-PEG conjugate showed maximum water uptake which increased with increase in concentration of conjugate. Same kind of property was reported by ElBarghouthi et al for chitosan silica complex (14).…”

Section: Water Penetration Ratesupporting

confidence: 58%

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Synthesis of MCC–PEG Conjugate and Its Evaluation as a Superdisintegrant

Bhalekar¹,

Desale²,

Madgulkar³

2010

AAPS PharmSciTech

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Abstract. PEGylated conjugate of microcrystalline cellulose (MCC) was synthesized by reacting MCC with polyethylene glycol (PEG) 200 in the presence of catalyst at elevated temperature. Conjugation between MCC and PEG was confirmed by FT-IR and 1 H NMR studies. The conjugate showed 61% PEG content increase in molecular weight determined by mass spectroscopy. PEGylation did not improve solubility of cellulose significantly. The physico-chemical properties of conjugate were compared against MCC. This conjugate was evaluated for water vapor uptake isotherms, maximum water saturation, water penetration rate, disintegration time, superdisintegration power, and dissolution study. After comparing its results with that of commercial superdisintegrants, it can be concluded that MCC-PEG conjugate can prove to be a good superdisintegrant.

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Section: Water Penetration Ratesupporting

confidence: 58%

“…This was performed by method described by El-Barghouthi et al (14). Conjugate powder was added to 25 ml of water in stepwise manner at room temperature, under stirring using magnetic stirrer, until saturation end point was reached, indicated by formation of solid mass of powder and no further stirring required.…”

Section: Maximum Water Saturationmentioning

confidence: 99%

Synthesis of MCC–PEG Conjugate and Its Evaluation as a Superdisintegrant

Bhalekar¹,

Desale²,

Madgulkar³

2010

AAPS PharmSciTech

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“…Other studies confirmed the mechanism of molecular interaction between chitosan and silica by infrared spectroscopy [26][27][28]. El-Barghouthi et al [28] investigated chitosan-silicate co-precipitates derived from colloidal silicon dioxide suspensions. In their study, chitosan-silica processing was basically a precipitation of the partially negatively charged silica onto the positively charged chitosan.…”

Section: Discussionmentioning

confidence: 61%

Chitosan Coating on Silica-Modified Polymethyl Methacrylate for Dental Applications

et al. 2017

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Abstract:Chitosan is a cationic natural polymer that is widely used as a topical dressing in wound management. Temporary coatings of removable denture bases with chitosan might be useful as supportive treatment in oral medicine. The aim of this study was to analyze the thickness, uniformity, and adhesive strength of chitosan coatings on simulated denture bases made from polymethyl methacrylate (PMMA). According to a standardized protocol, 20 PMMA cylinders (13 mm diameter, 5 mm in height) as well as 20 cubes (a = 25 mm) with intaglio U-shaped profiles were manufactured to simulate average sized alveolar ridges. Cylinders as well as cubes were divided into four test series with n = 5 each. After sandblasting with silica-modified alumina, one frontal surface of the PMMA cylinders and the intaglio surfaces of the U-shaped profiles was coated with chitosan acetate solution according to the following protocols: one layer of 2% chitosan acetate solution (test series I), one layer of 4% chitosan acetate solution (test series II), two layers of 2% chitosan acetate solution (test series III), and two layers of 4% chitosan acetate solution (test series IV). After drying and neutralization with NaOH, each cube was cut transversely and the coating thickness across the U-shaped profile assessed with a light microscope. Adhesive strength was evaluated by simulated tooth brushing and the loss of chitosan coating was evaluated qualitatively. Statistical analysis used Friedman ANOVA test for dependent samples and Kruskal-Wallis test for independent samples, post-hoc Dunn's test (p < 0.05), and binomial test (p = 0.05). The mean chitosan coating thicknesses in the depth of the U-profiles were 71 µm (test series I), 77 µm (test series II), 121 µm (test series III), and 517 µm (test series VI). The thickness continuously decreased with rising angulation of the U-profile side walls. In test series I, the chitosan coating thickness significantly dropped above a 30 • angulation of the U-profile side walls. In test series II to IV, the chitosan thickness drop was not statistically significant at angulations of 30 • and 60 • , but was at 90 • angulation of the U-profile side walls. Adhesion strength was rated fair to good and did not differ significantly among the four test series. The coating technique described revealed chitosan layers with overall good adhesion strength but differing thicknesses. Coatings with one or two layers of 4% chitosan acetate solution allowed a relatively uniform chitosan thickness and thus might be usable in oral medicine.

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“…Hence, it is more likely that weaker tablets will be formed by these materials as reflected in the friability. Evaluation of disintegration time shows that all the batches of tablets disintegrated within 1 min which is typical for co-processed excipients containing colloidal silicon dioxide (El-Barghouthi et al, 2008;Nagpal et al, 2012;Rojas and Kumar, 2011). A more rapid disintegration was observed in SAS-CG tablets.…”

Section: Tablet Propertiesmentioning

confidence: 99%

Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

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Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

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A Novel Superdisintegrating Agent Made from Physically Modified Chitosan with Silicon Dioxide

Cited by 71 publications

References 27 publications

Synthesis of MCC–PEG Conjugate and Its Evaluation as a Superdisintegrant

Synthesis of MCC–PEG Conjugate and Its Evaluation as a Superdisintegrant

Chitosan Coating on Silica-Modified Polymethyl Methacrylate for Dental Applications

Comparative analysis of co-processed starches prepared by three different methods

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