A novel subcutaneous infusion delivery system based on osmotic pump:in vitroandin vivoevaluation

Abstract

School of Pharmacy, Zhejiang University, Hangzhou, P.R. China AbstractAn economical, convenient portable drug delivery system combining osmotic pump with subcutaneous infusion was developed, which was composed of three primary components: water chamber, osmotic pump chamber and support base. Ceftriaxone sodium (CRO) was selected as the model drug and osmotic pump tablets were prepared. The influence of osmotic agents on drug release profiles was evaluated. As the adjustment made by the osmotic agents was limited, the compositions of semipermeable membrane were investigated to determine significant associations of factors based on orthogonal design. The in vitro release profiles of the optimum formulation achieved to the predetermined value (15 AE 3 min for the initial release time T i and 5.75 AE 0.25 h for the extent release time T e ). The pharmacokinetic profiles of this drug delivery system were evaluated in Beagle dogs. In vivo results demonstrated that the osmotic pump subcutaneous infusion administration was equivalent to intravenous injection administration in terms of bioavailability. Moreover, constant drug plasma levels with minimized fluctuations could be achieved with this osmotic pump subcutaneous infusion system, compared with intravenous injection.

The Comparative Utility of Viromer RED and Lipofectamine for Transient Gene Introduction into Glial Cells

“…With the advent of CRISPR/CAS genome editing, HTS, and the optimized drug discovery work flow, the demand for effective, scalable, quick to set up gene delivery methods is an expanding need. Research studies into developing novel nonviral gene delivery agents continue to grow and have provided important data on their feasibility and applicability [ 26 , 27 ]. This is illustrated by the recent investigation of at least 7 different nonviral delivery systems in various phases of clinical study [ 18 ].…”

Microfluidics for Drug Development: From Synthesis to Evaluation

“…Gong et al also developed an osmotic micropump with an additional water chamber that enabled the release process to be actuated without extra release medium. 316 With this device, the subcutaneous administration of ceftriaxone sodium was realized, exhibiting constant blood concentration with minimized fluctuations in contrast to intravenous injection.…”

“…The saturated salt solution was diluted and amplified by the water chamber through the linking hollow fiber, after which the diluted solution entered the extrusion chamber, leading to the release of the liquid in the compressible reservoir. Gong et al also developed an osmotic micropump with an additional water chamber that enabled the release process to be actuated without extra release medium . With this device, the subcutaneous administration of ceftriaxone sodium was realized, exhibiting constant blood concentration with minimized fluctuations in contrast to intravenous injection.…”

The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive

“…Comprehensive grading method was employed to evaluate the release profiles of various formulations compared with the ideal release profiles. The score of various formulations was calculated by the following equation (Gong et al, 2014):…”

“…There are some successful reports about the development of drug delivery systems by utilizing osmosis (Theeuwes & Yum, 1976;Lee & Cima, 2011). Previously, our research team has reported an osmotic tablet pump for subcutaneous infusion (Gong et al, 2014). However, this infusion system was difficult to maintain its sterility during the preparation process, and the drug content cannot be altered once manufacturing is completed.…”