2017
DOI: 10.1080/10717544.2016.1230903
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A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles

Abstract: Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specifi… Show more

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Cited by 80 publications
(52 citation statements)
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“…Recently, biomimetic camouflaging using cell membranes has emerged as a new strategy to overcome these obstacles of the in vivo application of synthetic nanoparticles . Extracted membranes of natural cells can be repurposed into liposome‐like shells or coatings without significant loss to the microscopic structure and protein profile of the source cell surface, which would be very difficult to reproduce through synthetic means . Compared to conventional coatings, such a biomimetic nanosurface likely holds a better chance to camouflage itself as “natural” when introduced into the body, and minimize the nano–bio interface alterations or reactions triggered by many synthetic surfaces .…”
mentioning
confidence: 99%
“…Recently, biomimetic camouflaging using cell membranes has emerged as a new strategy to overcome these obstacles of the in vivo application of synthetic nanoparticles . Extracted membranes of natural cells can be repurposed into liposome‐like shells or coatings without significant loss to the microscopic structure and protein profile of the source cell surface, which would be very difficult to reproduce through synthetic means . Compared to conventional coatings, such a biomimetic nanosurface likely holds a better chance to camouflage itself as “natural” when introduced into the body, and minimize the nano–bio interface alterations or reactions triggered by many synthetic surfaces .…”
mentioning
confidence: 99%
“…In recent years, much attention has been given to alternatives to PEG, i.e., poloxamer, polyvinylpyrrolidone (PVP) and dextran [47]. Other strategies to prevent MPS engulfment of NPs include (i) the saturation of receptors expressed on Kupffer cells with nontoxic NPs prior to administration of a nanotherapeutic [51]; (ii) the specific transient depletion of macrophages by the injection of dichloromethylene-bisphosphonate-or clodronate-loaded liposomes or substances like gadolinium chloride, methyl palmitate, dextran sulfate, and carrageenan [17,51]; (iii) bio-inspired cell-based approaches which consist in using cells, i.e., red blood cells, platelets, leukocytes, monocytes, and stem cells as drug delivery systems [52,53].…”
Section: Protein Corona and Macrophage Eliminationmentioning
confidence: 99%
“…Gold nanoparticles with either positive or negative surface charges surprisingly showed peroxidase mimicking activity [88]. Peroxidase-like activity is used for colorimetric detection of urea, urease and urease inhibitor [89]. Gold nanoparticles based on peroxidase function are used to detect kanamycin residue by catalyzingthe reaction between H 2 O 2 and reduced thionine to produce oxidized thionine [67].…”
Section: Gold Nanomaterialsmentioning
confidence: 99%