Nanozyme applications in biology and medicine: an overview

Golchin, Jafar; Golchin, Kazem; Alidadian, Neda; Ghaderi, Shahrooz; Eslamkhah, Sajjad; Eslamkhah, Masoud; Akbarzadeh, Abolfazl

doi:10.1080/21691401.2017.1313268

Cited by 110 publications

(56 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NZs have the potential for serving as antioxidants in the treatment of autoimmune, Alzheimer's and Parkinson's diseases, and for application as antibacterial agents. Using NZs in the construction of biosensors [18,19,[22][23][24] and biofuel cells is very promising, where high catalytic activity, chemical and biological stability, nanoscale size of catalytic elements, and more cost-effective preparation are the most important challenges.…”

Section: High Selectivitymentioning

confidence: 99%

Synthesis, Catalytic Properties and Application in Biosensorics of Nanozymes and Electronanocatalysts: A Review

Stasyuk

Smutok

Demkiv

et al. 2020

Sensors

View full text Add to dashboard Cite

The current review is devoted to nanozymes, i.e., nanostructured artificial enzymes which mimic the catalytic properties of natural enzymes. Use of the term “nanozyme” in the literature as indicating an enzyme is not always justified. For example, it is used inappropriately for nanomaterials bound with electrodes that possess catalytic activity only when applying an electric potential. If the enzyme-like activity of such a material is not proven in solution (without applying the potential), such a catalyst should be named an “electronanocatalyst”, not a nanozyme. This paper presents a review of the classification of the nanozymes, their advantages vs. natural enzymes, and potential practical applications. Special attention is paid to nanozyme synthesis methods (hydrothermal and solvothermal, chemical reduction, sol-gel method, co-precipitation, polymerization/polycondensation, electrochemical deposition). The catalytic performance of nanozymes is characterized, a critical point of view on catalytic parameters of nanozymes described in scientific papers is presented and typical mistakes are analyzed. The central part of the review relates to characterization of nanozymes which mimic natural enzymes with analytical importance (“nanoperoxidase”, “nanooxidases”, “nanolaccase”) and their use in the construction of electro-chemical (bio)sensors (“nanosensors”).

show abstract

Section: High Selectivitymentioning

confidence: 99%

Synthesis, Catalytic Properties and Application in Biosensorics of Nanozymes and Electronanocatalysts: A Review

Stasyuk

Smutok

Demkiv

et al. 2020

Sensors

View full text Add to dashboard Cite

show abstract

“…On the other hand, many effects have been made to improve inorganic nanozyme, both its catalysis capacity and substrate specificity, particularly for the "engineering peroxidase" related to iron oxide for its analytical, biomedical, and environmental applications from the view of nanoengineering [46,47,154,155]. Various polymers or other organic compounds, e.g., porphyrin rings, the backbones of short peptides, amino acids, and even DNA, have been employed in the stabilization of the oxo bridged Fe-metal center in different iron oxides [156][157][158][159][160].…”

Section: Natural and Inorganic Phosphatasementioning

confidence: 99%

Iron Oxide Nanoparticles: An Inorganic Phosphatase

Huang¹

2019

Nanocatalysts

View full text Add to dashboard Cite

Phosphorus is one of the most important macronutrients for the primary production. The transformation of dissolved organic phosphorus in the environment and its contribution to biological production in the different ecosystems is still a mystery. Recently, it was demonstrated that phosphate ester can be rapidly hydrolyzed in solutions containing iron oxide nanoparticles with enzyme kinetics. The catalyst is sensitive to temperature and pH changes and inhibited by tetrahedral oxyanions with an order of PO 4 < MoO 4 < WO 4. The oxo-Fe structure in the iron oxide nanoparticles, like the metal center of natural phosphatase (e.g., purple acid phosphatase, PAP), might contribute to the observed catalytic activity. Iron oxide nanoparticles are very common and widely exist in the current earth environment, and phosphate esters are the main component of dissolved organic phosphorus in soil and waters. It is expected that iron oxide nanoparticles in aqueous environments, as an inorganic phosphatase, play a critical role for the phosphorus transformation from the view of the phosphorus cycle.

show abstract

“…Exceptional interest in nanozymes resulted in several extended review papers covering in detail their classification, catalytic mechanisms, activity regulation and applications in biosensing, environmental protection, disease treatments and other applications (Golchin et al 2017;Huang et al 2019;Wu et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Biochars and their magnetic derivatives as enzyme-like catalysts mimicking peroxidases

Šafařı́k

Procházková

Baldíková

et al. 2020

Biochar

View full text Add to dashboard Cite

Various materials have been extensively investigated to mimic the structures and functions of natural enzymes. We describe the discovery of a new catalytic property in the group of biochar-based carbonaceous materials, which are usually produced during biowaste thermal processing under specific conditions. The tested biochars exhibited peroxidase-like catalytic activity. Biomaterial feedstock, pyrolysis temperature, size of resulting biochar particles or biochar modification (e.g., magnetic particles deposition) influenced the peroxidase-like activity. Catalytic activity was measured with the chromogenic organic substrates N,N-diethyl-p-phenylenediamine (DPD) or 3,3′,5,5′-tetramethylbenzidine (TMB), in the presence of hydrogen peroxide. Magnetic biochar composite was studied as a complementary material, in which the presence of iron oxide particles enhances catalytic activity and enables smart magnetic separation of catalyst even from complex mixtures. The activity of the selected biochar had an optimum at pH 4 and temperature 32 °C; biochar catalyst can be reused ten times without the loss of activity. Using DPD as a substrate, K m values for native wood chip biochar and its magnetic derivative were 220 ± 5 μmol L −1 and 690 ± 80 μmol L −1 , respectively, while V max values were 10.1 ± 0.3 μmol L −1 min −1 and 16.1 ± 0.4 μmol L −1 min −1 , respectively. Biochar catalytic activity enabled the decolorization of crystal violet both in the model solution and the fish pond water containing suspended solids and dissolved organic matter. The observed biochar enzyme mimetic activity can thus find interesting applications in environmental technology for the degradation of selected xenobiotics. In general, this property predestines the low-cost biochar to be a perspective supplement or even substitution of common peroxidases in practical applications.

show abstract

Nanozyme applications in biology and medicine: an overview

Cited by 110 publications

References 94 publications

Synthesis, Catalytic Properties and Application in Biosensorics of Nanozymes and Electronanocatalysts: A Review

Synthesis, Catalytic Properties and Application in Biosensorics of Nanozymes and Electronanocatalysts: A Review

Iron Oxide Nanoparticles: An Inorganic Phosphatase

Biochars and their magnetic derivatives as enzyme-like catalysts mimicking peroxidases

Contact Info

Product

Resources

About