A novel staphylococcal enterotoxin SE02 involved in a staphylococcal food poisoning outbreak that occurred in Tokyo in 2004

Suzuki, Yasunori; Ono, Hisaya K.; Shimojima, Yukako; Kubota, Hiroaki; Kato, Ryuji; Kakuda, Tsutomu; Hirose, Shouhei; Hu, Dong‐Liang; Nakane, Akio; Takaı̈, Shinji; Sadamasu, Kenji

doi:10.1016/j.fm.2020.103588

Cited by 27 publications

(28 citation statements)

References 41 publications

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“…Of them, SEC was further subdivided into 3 subtypes, SEC1, SEC2 and SEC3 (Bergdoll et al 1973). Since the 1990s, many new types of SEs and SEls were discovered by our research group (Omoe et al 2003;Ono et al 2008Ono et al , 2015Suzuki et al 2020) and other researchers (Aguilar et al 2014;Letertre et al 2003;Munson et al 1998;Orwin et al 2001Orwin et al , 2003Su and Wong 1995;Thomas et al 2006;Wilson et al 2011;Zhang et al 2018). The International Nomenclature Committee for Staphylococcal Superantigens (INCSS) proposed a standard nomenclature for newly discovered toxins to emphasize the emetic activity of toxins (Lina et al 2004;Omoe et al 2013).…”

Section: Ses and Selsmentioning

confidence: 99%

“…Staphylococcus aureus produces a variety of exotoxins and proteases that contribute to their ability to colonize and cause disease in humans and animals. Superantigen (SAg) toxins are important exotoxins of S. aureus, including staphylococcal enterotoxin A (SEA) to SEE, SEG to SET, staphylococcal enterotoxin-like toxins U (SElU) to SElY, SE01, SE02, SEl26, SEl27 and toxic shock syndrome toxin-1 (TSST-1) (Dinges et al 2000;Hu and Nakane 2014;Ono et al 2015;Suzuki et al 2020;Zhang et al 2018). SAg toxins are proteins composed of approximately 168-261 amino acids, with molecular size of 19-30 kDa (Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, SEs are a major cause of food poisoning, which typically occur after ingestion of food contaminated with S. aureus. Symptoms of food poisoning rapid onset, include nausea and violent vomiting, with or without diarrhea (Bergdoll 1988;Hu et al 1999, Hu et al, 2003a Hu et al, 2017;Suzuki et al 2020). In addition, recent studies reported that SAg-modified vaccines showed therapeutic effects in melanoma-bearing mice and had a strong protective effect against wild-type melanoma challenge (Kato et al 2011;Huang et al 2004;).…”

Section: Introductionmentioning

confidence: 99%

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Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Fang

et al. 2021

Animal Diseases

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Staphylococcal superantigen (SAg) toxins are the most notable virulence factors associated with Staphylococcus aureus, which is a pathogen associated with serious community and hospital acquired infections in humans and various diseases in animals. Recently, SAg toxins have become a superfamily with 29 types, including staphylococcal enterotoxins (SEs) with emetic activity, SE-like toxins (SEls) that do not induce emesis in primate models or have yet not been tested, and toxic shock syndrome toxin-1 (TSST-1). SEs and SEls can be subdivided into classical types (SEA to SEE) and novel types (SEG to SElY, SE01, SE02, SEl26 and SEl27). The genes of SAg toxins are located in diverse accessory genetic elements and share certain structural and biological properties. SAg toxins are heat-stable proteins that exhibit pyrogenicity, superantigenicity and capacity to induce lethal hypersensitivity to endotoxin in humans and animals. They have multiple pathogenicities that can interfere with normal immune function of host, increase the chances of survival and transmission of pathogenic bacteria in host, consequently contribute to the occurrence and development of various infections, persistent infections or food poisoning. This review focuses on the following aspects of SAg toxins: (1) superfamily members of classic and novelty discovered staphylococcal SAgs; (2) diversity of gene locations and molecular structural characteristics; (3) biological characteristics and activities; (4) multi-pathogenicity of SAgs in animal and human diseases, including bovine mastitis, swine sepsis, abscesses and skin edema in pig, arthritis and septicemia in poultry, and nosocomial infections and food-borne diseases in humans.

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Section: Ses and Selsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Fang

et al. 2021

Animal Diseases

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“…Among all staphylococcal toxins, SEs have been the most frequently associated with foodborne diseases, causing emesis and T-cell activation [29]. There are at least 26 different SEs characterized, but this number could be even higher [10]. These toxins are resistant to heat and acidity and to the hydrolysis mediated by most proteolytic enzymes [1,17].…”

Section: Staphylococcal Enterotoxins and Virulence Factorsmentioning

confidence: 99%

“…This may lead to food intoxication due to the presence of staphylococcal exotoxins, which were firstly identified in 1992 [7]. Moreover, the inappropriate manipulation of fresh food may lead to outbreaks originated in restaurants because S. aureus could also be transmitted from human carriers during food handling [10,11]. Furthermore, food production animals, including pigs, cattle, or chickens, may also be carriers of S. aureus [1].…”

Section: Introductionmentioning

confidence: 99%

Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

et al. 2021

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Staphylococcal infections are a widespread cause of disease in humans. In particular, S. aureus is a major causative agent of infection in clinical medicine. In addition, these bacteria can produce a high number of staphylococcal enterotoxins (SE) that may cause food intoxications. Apart from S. aureus, many coagulase-negative Staphylococcus spp. could be the source of food contamination. Thus, there is an active research work focused on developing novel preventative interventions based on food supplements to reduce the impact of staphylococcal food poisoning. Interestingly, many plant-derived compounds, such as polyphenols, flavonoids, or terpenoids, show significant antimicrobial activity against staphylococci, and therefore these compounds could be crucial to reduce the incidence of food intoxication in humans. Here, we reviewed the most promising strategies developed to prevent staphylococcal food poisoning.

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Exotoxins of Staphylococcus aureus

Hu,

Ono,

et al. 2024

Staphylococcus Aureus

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A novel staphylococcal enterotoxin SE02 involved in a staphylococcal food poisoning outbreak that occurred in Tokyo in 2004

Cited by 27 publications

References 41 publications

Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins

Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

Exotoxins of Staphylococcus aureus

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