Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

Mourenza, Álvaro; Gil, José A.; Mateos, Luís M.; Letek, Michal

doi:10.3390/pathogens10020091

Cited by 11 publications

(6 citation statements)

References 108 publications

(168 reference statements)

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“…Staphylococcal food poisoning (SFP) is widespread and is becoming one of the most common causes of foodborne disease, with the case number continuously increasing since it was first reported [ 48 , 49 , 50 ]. Staphylococcus spp.…”

Section: Staphylococcus Aureus Caused Food Poisoningmentioning

confidence: 99%

Staphylococcus aureus Infections and Human Intestinal Microbiota

Liu,

Garrett,

Hong

et al. 2024

Pathogens

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Staphylococcus aureus (S. aureus) is a common pathogen that can cause many human diseases, such as skin infection, food poisoning, endocarditis, and sepsis. These diseases can be minor infections or life-threatening, requiring complex medical management resulting in substantial healthcare costs. Meanwhile, as the critically ignored “organ,” the intestinal microbiome greatly impacts physiological health, not only in gastrointestinal diseases but also in disorders beyond the gut. However, the correlation between S. aureus infection and intestinal microbial homeostasis is largely unknown. Here, we summarized the recent progress in understanding S. aureus infections and their interactions with the microbiome in the intestine. These summarizations will help us understand the mechanisms behind these infections and crosstalk and the challenges we are facing now, which could contribute to preventing S. aureus infections, effective treatment investigation, and vaccine development.

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Section: Staphylococcus Aureus Caused Food Poisoningmentioning

confidence: 99%

Staphylococcus aureus Infections and Human Intestinal Microbiota

Liu,

Garrett,

Hong

et al. 2024

Pathogens

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“…Кроме Endocarditis [88], toxic shock syndrome [131], food poisoning [110], skin diseases [124], respiratory system diseases [13], genital tract infections [130]…”

Section: бактерии группы Eskape: характеристика представителей группы...mentioning

confidence: 99%

Crosstalk between ESKAPE bacteria and NK cells: mutual regulation and role in developing reproductive tract pathologies

Grebenkina,

Selkov,

Kraeva

et al. 2023

Russian Journal of Infection and Immunity

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Natural killer (NK) cells represent one of the innate lymphoid cell subsets, which are often studied in the context of antitumor and antiviral immunity, as well as due to their localization in the zone of the mother-fetus contact (in the uterus), therefore underlying their extensive investigation in developing pregnancy. At the same time, their role in antibacterial immune response has been poorly examined. Because NK cells can produce cytokines, one of putative options for their participation in eliminating prokaryotic pathogens may be coupled to regulation of immune system cells such as dendritic cells, macrophages, etc. However, there have been also described variants of contact cytolysis of cells infected with intracellular bacteria enabled due to cytotoxic proteins perforin, granzymes, granulisin found in NK cells. In recent years, it has become known that NK cells take part in development of immune response against extracellular bacteria including the ESKAPE group bacteria, which includes opportunistic prokaryotes that most actively develop antibiotic resistance and cause nosocomial infections. Here, we attempted to review the data on the role NK cells play in antibacterial immunity. Assessing a crosstalk between ESKAPE group bacteria and NK cells also attracts researchers due to the ability of prokaryotes to alter functions of immune cells, but very little is known about the effects they exert on NK cells. At the same time, such data could be applied to seek out for new ways to treat oncological diseases as well as pave the basis for new approaches to regulating NK cell characteristics in reproductive pathologies. As mentioned earlier, the latter occur in the decidual membrane, where they can interact with fetal cells including trophoblast cells. It is believed that cells can mutually regulate each others properties necessary for the course of physiological pregnancy. Probably, imbalance in this system can lead to development of reproductive pathologies. The review summarizes the currently available data on the effects of ESKAPE group bacteria on NK cells, and also considers putative mechanisms for emergence of impaired interaction between NK cells and trophoblasts exposed to ESKAPE group bacteria. Owing to few publications available on this phenomenon, the experimental study assessing an impact of ESKAPE group bacteria on NK cell properties is envisioned as a necessary stage in development of contemporary biology.

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“…Ingestion of staphylococcal enterotoxins may cause gastroenteritis and result in symptoms like nausea, vomiting, diarrhoea and abdominal pain (Chen and Xie 2019; Mourenza et al . 2021).…”

Section: Introductionmentioning

confidence: 99%

New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus

Formagio

Silva

Prohmann

et al. 2022

Letters in Applied Microbiology

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Staphylococcus aureus is one of the main aetiological agents causing food‐borne diseases. Some strains produce enterotoxins responsible for food poisoning. In addition, they can form biofilms on several surfaces such as plastics, glass and stainless steel making it difficult to eliminate them. The present study evaluated, for the first time, the antibacterial and antibiofilm activities of the synthetic compound LMM6 against S. aureus. The minimum inhibitory concentration was 0·97, 1·95 and 1·95 μg ml−1 against S. aureus ATCC 25923, S. aureus 629/94 and S. aureus FRI S‐6, respectively. The time‐kill curves showed that 96 h treatment with LMM6 reduced approximately 4 log CFU per ml at all tested concentrations. Furthermore, LMM6 reduced S. aureus preformed biofilm by approximately 1 log CFU per cm2. During biofilm formation, a reduction of approximately 4 log CFU per cm2 was observed. LMM6 also reduced biofilm biomass during (~60%) and after biofilm formation (~25 to 45%), as shown by the crystal violet assay. Based on these results, we conclude that LMM6 exhibits antibacterial and antibiofilm activity and may be an innovative synthetic molecule for controlling S. aureus.

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Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

Cited by 11 publications

References 108 publications

Staphylococcus aureus Infections and Human Intestinal Microbiota

Staphylococcus aureus Infections and Human Intestinal Microbiota

Crosstalk between ESKAPE bacteria and NK cells: mutual regulation and role in developing reproductive tract pathologies

New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus

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