A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum

Abstract

Two new triterpenoids, teuviscins A (1) and B (2), were isolated from the whole plants of Teucrium viscidum. Compound 2 showed anti-AD bioactivity which delayed animals paralysis of transgenic AD C. elegans.

Caesalpinbondin A, a Novel Diterpenoid Lactone With an Unprecedented Carbon Skeleton from the Seeds of Caesalpinia bonduc

“…For its cheapness, easy and fast-breeding, and AD pathological similarity, the transgenic AD C. elegans model has been used as a powerful tool for rapid screening of anti-AD drugs (Xin et al, 2013). Using transgenic AD C. elegans paralysis assay, we have successfully discovered several natural products with potential anti-AD effects (Li et al, 2017;Wu et al, 2018;Su et al, 2021). As shown in Figure 6, compound 1 significantly delayed the Aβ-induced paralysis in CL4176 nematodes (p < 0.05).…”

“…In our continuing search for structurally novel and biologically interesting natural products of Chinese medicinal plants (Fei et al, 2016;Li et al, 2017;Wu et al, 2018;Zhang et al, 2018;Yu et al, 2020;Li et al, 2022), a novel diterpenoid, caesalpinbondin A (1) (Figure 1), was isolated from the 95% ethanol extract of the seeds of C. bonduc. Compound 1 represented a novel tetracyclic ring system in which a 6/6/5-fused tricyclic ring and a 4,5dimethyldihydrofuran-2(3H)-one moiety were connected by a C-C single bond comprising an unprecedented 5-(naphtho [2,3b]furan-7-yl)dihydrofuran-2(3H)-one scaffold.…”

Spirocyclic Motifs in Natural Products

“…Secondary metabolite investigation of Teucrium viscidum led to the identification of a [4.5.0] spirocyclic compound ( 77 ) possessing a unique skeleton [57]. A skeleton of similar complexity had only been featured once in the literature three decades before that [58] (Figure 31).…”

Isolation, Characterization, and Possible Anti‐Alzheimer's Disease Activities of Bisabolane‐Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

“…During our search for pharmacologically active substances from plants, much attention has been given to natural vegetable foods, such as natural spices, because they may be potentially beneficial for human health. From the ethanol extract of the rhizomes of C. longa , one new bisabolane‐type sesquiterpenoid 1 , as well as four known bisabolane‐type sesquiterpenoid derivatives 2–5 and seven phenolics 6–12 , was isolated ( Figure ).…”