A novel single step synthesis of 2-methyl-6-phenylpyridine from non-heterocyclic compounds over molecular sieve catalysts

A single step synthesis of 2-phenylpyridine from acetophenone, ethanol, formaldehyde and ammonia over molecular sieve catalystsIICT Communication No. 4718.

“…The HZSM-5 (30) zeolite was obtained from Conteka (Sweden), Hb (20) was obtained from Sud-chemie (India) and HY (2.6) zeolite was obtained from PQ Corporation (USA). The catalyst powders were pelletized and sized (18-30-mesh).…”

“…Recently large pore zeolites and mesoporous molecular sieve catalysts are reported to be excellent catalysts especially for the synthesis of large molecules. [15][16][17][18][19] Previous work in our laboratory has established that the combination of acidity, thermal stability and uniform pore structure of a molecular sieve catalyst provides a good opportunity for the synthesis of large size molecules such as 2-methyl-6-phenylpyridine 20 and 5-methyl-2-phenylpyridine. 21 To the best of our knowledge, this is the first report of the synthesis of 2-phenylpyridine from acetophenone, ethanol, formaldehyde and ammonia over various molecular sieve catalysts in vapor phase reactions.…”

Synthesis of N-heterocyclic compounds over zeolite molecular sieve catalysts: an approach towards green chemistry

“…However, various substituted pyridines were often synthesized over microporous materials from cheaper chemicals via the Hantzsch route. [62][63][64][65][66][67] Radha Rani et al reported the synthesis of 2-phenyl pyridine using acetophenone, allyl alcohol and ammonia over zeolites and mesoporous materials. 68 The reaction was studied over various zeolites (HY, H-beta, HX, HZSM-5), SiO 2 -Al 2 O 3 and MCM-41 at 360 1C (Scheme 7).…”

Rice husk ash supported FeCl2·2H2O: A mild and highly efficient heterogeneous catalyst for the synthesis of polysubstituted quinolines by Friedländer heteroannulation

“…Various solid acid catalysts have been used in the Friedländer reaction such as Ag3PW12O40 [21], sulfamic acid [22], HClO4 -SiO2 [23], amberlyst-15 [24], dodecylphosphonic acid [25], o-benzenedisulfonimide [26], SnCl2 [27], FeCl3 [28], Mg(ClO4)2 [29], Nd(NO3)3 [30], Y(OTf)3 [31], NiCl2 [32], I2/CAN [33], Na-HSO4-SiO2 [34], poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [35], and KOtBu [36].…”

“…Ferric chloride is a conventional homogeneous acid catalyst, but it has several disadvantages such as a high degree of corrosiveness, long work-up, necessity of stoichiometric quantities, the presence of several undesirable side products, and the single use of catalysts. Therefore, it is highly undesirable from an ecological point of view [36]. Although FeCl3 is very active during the synthesis of polymers, it has low regioselectivity, which can lead to polymers with regioirregular structures and many side products [37,38].…”