A novel simple one-step air jet spinning approach for deposition of poly(vinyl acetate)/hydroxyapatite composite nanofibers on Ti implants

Abdal‐hay, Abdalla; Hamdy, Abdel Salam; Khalil, Khalil Abdelrazek; Lim, Jun Woo

doi:10.1016/j.msec.2015.01.008

Cited by 46 publications

(40 citation statements)

References 51 publications

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“…This technology has been reported as a one‐step low‐cost process with high production rate over short time based on the use of pressurized gas, which is dispensed at an extreme speed in order to stretch the polymer solution into thin fibers at the nozzle outlet. At the same instant, the solvent starts to evaporate and continues to do so after the fibers are deposited onto a substrate . Our results by SEM characterization demonstrated that we were able to collect and fabricate, by the AJT, PLA membrane scaffolds with nanometric, random fiber structure, where the concentration of PLA exerts a direct effect on the mean diameter size of the fibers.…”

Section: Discussionmentioning

confidence: 72%

“…At the same instant, the solvent starts to evaporate and continues to do so after the fibers are deposited onto a substrate. 38,39 Our results by SEM characterization demonstrated that we were able to collect and fabricate, by the AJT, PLA membrane scaffolds with nanometric, random fiber structure, where the concentration of PLA exerts a direct effect on the mean diameter size of the fibers. This nanometric fiber structure could achieve the desirable functionality, mimicking the intricate interaction between cells and their microenvironment with respect to the ECM and our results are in accordance with recent studies using the AJT technology, that report similar fiber diameter structure and validate good biocompatibility properties of these spun mats.…”

Section: Discussionmentioning

confidence: 77%

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In vitroandin vivobiological characterization of poly(lactic acid) fiber scaffolds synthesized by air jet spinning

Granados-Hernández

Serrano-Bello²,

Montesinos

et al. 2017

J Biomed Mater Res

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Poly(lactic acid) (PLA) is one of the most promising renewable and biodegradable polymers for mimic extracellular matrix for tissue engineering applications. In this work, PLA spun membrane scaffold were successfully prepared by air jet spinning technology. Morphology, mechanical properties, in vitro biocompatibility, and in vitro and in vivo degradation of PLA fibrous scaffold were characterized by X-ray diffraction, Fourier Transform Infrared, and scanning electron microscope (SEM). Morphological results assessed by SEM analyses indicated that PLA scaffolds possessed an average fiber diameter of approximately 0.558 ± 0.141 µm for 7% w/v of PLA and approximately 0.647 ± 0.137 µm for 10% w/v. Interestingly, our results showed that the nanofiber size of PLA scaffold allow structural stability after 100 days of in vitro degradation in Ringer solution where the average fiber diameter were of approximately 0.633 ± 0.147 µm for 7% w/v and approximately 0.645 ± 0.140 µm for 10% w/v of PLA. Mechanical properties of PLA fibers scaffold after in vitro degradation showed decrease in terms of flexibility elongation, and less energy was needed to achieve maximal elastic deformation. The fiber size exerts an influence on the biological response of human Bone Marrow Mesenchymal Stromal Cells as confirmed by MTT assay after 9 days of cell culture and the in vivo degradation assay of 7% w/v and 10% w/v of PLA scaffold, did not demonstrate evidence of toxicity with a mild inflammatory respond. In conclusion, airbrushing technology promises to be a viable and attractive alternative technique for producing a biocompatible PLA nanofiber scaffold that could be considered for tissue engineering regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2435-2446, 2018.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 77%

In vitroandin vivobiological characterization of poly(lactic acid) fiber scaffolds synthesized by air jet spinning

Granados-Hernández

Serrano-Bello²,

Montesinos

et al. 2017

J Biomed Mater Res

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“…This inert polymer has the advantage that it does not induce a deleterious reaction in living tissue (Sadato et al, 1994). Because of all these characteristics PVAc has been used in many medical fields, including drug and cell carries and in tissue engineering (Abdal-hay et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Laser-treated electrospun fibers loaded with nano-hydroxyapatite for bone tissue engineering

Aragón

Navascués

Mendoza

et al. 2017

International Journal of Pharmaceutics

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Core-shell polycaprolactone/polycaprolactone (PCL/PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) electrospun fibers loaded with synthesized nanohydroxyapatite (HAn) were lased treated to create microporosity. The prepared materials were characterized by XRD, FTIR, TEM and SEM. Uniform and randomly oriented beadless fibrous structures were obtained in all cases. Fibers diameters were in the 150-300nm range. Needle-like HAn nanoparticles with mean diameters of 20nm and length of approximately 150nm were mostly encase inside the fibers. Laser treated materials present micropores with diameters in the range 70-120μm for PCL-HAn/PCL fibers and in the 50-90μm range for PCL-HAn/PVAC material. Only samples containing HAn presented bioactivity after incubation during 30days in simulated body fluid. All scaffolds presented high viability, very low mortality, and human osteoblast proliferation. Biocompatibility was increased by laser treatment due to the surface and porosity modification.

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“…Although there have been many studies to explore the compatibility of airbrush spraying with a number of polymers for production of nanofibers or thin films, there have been only a few studies on the compatibility of airbrush spraying with hydrogels. The possibility of in situ deposition of thermoresponsive hydrogels holds promise for a host of applications ranging from the treatment of burn wounds and ulcers to the regeneration of bone and cartilage tissue defects.…”

Section: Introductionmentioning

confidence: 99%

“…Since then, researchers have explored the compatibility of spraying with a number of cell types, including epithelial and smooth muscle cells for coating tissueengineered constructs like trachea or bronchi, 16 keratinocytes and bovine dermal fibroblasts for chronic or burn wound healing, 17,18 and chondrocytes for cartilage repair. 14 Although there have been many studies to explore the compatibility of airbrush spraying with a number of polymers for production of nanofibers 13,[19][20][21][22][23][24][25][26][27] or thin films, [28][29][30] there have been only a few studies 31,32 on the compatibility of airbrush spraying with hydrogels. The possibility of in situ deposition of thermoresponsive hydrogels holds promise for a host of applications ranging from the treatment of burn wounds and ulcers to the regeneration of bone and cartilage tissue defects.…”

Section: Introductionmentioning

confidence: 99%

In situ spray deposition of cell‐loaded, thermally and chemically gelling hydrogel coatings for tissue regeneration

Kara

Ekenseair

2016

J Biomedical Materials Res

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In this study, the efficacy of creating cellular hydrogel coatings on warm tissue surfaces through the minimally invasive, sprayable delivery of thermoresponsive liquid solutions was investigated. Poly(N-isopropylacrylamide)-based (pNiPAAm) thermogelling macromers with or without addition of crosslinking polyamidoamine (PAMAM) macromers were synthesized and used to produce in situ forming thermally and chemically gelling hydrogel systems. The effect of solution and process parameters on hydrogel physical properties and morphology was evaluated and compared to poly(ethylene glycol) and injection controls. Smooth, fast, and conformal hydrogel coatings were obtained when pNiPAAm thermogelling macromers were sprayed with high PAMAM concentration at low pressure. Cellular hydrogel coatings were further fabricated by different spraying techniques: single-stream, layer-by-layer, and dual stream methods. The impact of spray technique, solution formulation, pressure, and spray solution viscosity on the viability of fibroblast and osteoblast cells encapsulated in hydrogels was elucidated. In particular, the early formation of chemically crosslinked micronetworks during bulk liquid flow was shown to significantly affect cell viability under turbulent conditions compared to injectable controls. The results demonstrated that sprayable, in situ forming hydrogels capable of delivering cell populations in a homogeneous therapeutic coating on diseased tissue surfaces offer promise as novel therapies for applications in regenerative medicine. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2383-2393, 2016.

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A novel simple one-step air jet spinning approach for deposition of poly(vinyl acetate)/hydroxyapatite composite nanofibers on Ti implants

Abstract: Este documento contiene información de prueba. Contáctese con el administrador del Centro para el acceso al documento originar del registro.

Cited by 46 publications

References 51 publications

In vitroandin vivobiological characterization of poly(lactic acid) fiber scaffolds synthesized by air jet spinning

In vitroandin vivobiological characterization of poly(lactic acid) fiber scaffolds synthesized by air jet spinning

Laser-treated electrospun fibers loaded with nano-hydroxyapatite for bone tissue engineering

In situ spray deposition of cell‐loaded, thermally and chemically gelling hydrogel coatings for tissue regeneration

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