A Novel Sensitive Electrochemical Sensor Based on Nickel Chloride Solution Modified Glassy Carbon Electrode for Curcumin Determination

Abstract

In this research, the high conductivity of nickel chloride solution as well as the ability of nickel ions in establishing particular bonds with curcumin was benefited to fabricate a new electrochemical sensor based on nickel chloride solution modified glassy carbon electrode (NiCl2/GCE) for detection and measurement of curcumin in human blood serum. Atomic force microscope (AFM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) methods indicated that using nickel chloride solution for the modification of the glassy carbon electrode (GCE) surface had a significant effect on improvement of the electrode performance. Differential pulse voltammetry (DPV) was used for quantitative measurement of curcumin, which exhibited the linear response of NiCl2/GCE toward curcumin within the concentration range of 10–600 μM and provided the detection limit of 0.109 μM for curcumin in human blood serum.

Degradation‐triggered release from biodegradable metallic surfaces

“…Nevertheless, there was a significant difference in curcumin oxidation peak current intensity between the c‐Zn and c‐Fe samples as higher and more intense peaks were observed for the former. The enhancement of curcumin oxidation peak current signified the higher concentration of curcumin in the media 54‐57 . Since a higher curcumin release has been observed for the c‐Zn, more oxidation of curcumin was expected to take place in the media compared to that of c‐Fe.…”

A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin

“…The linear regression equations are i pa (μA) = 0.40491 ν (mV s −1 ) + 0.595 (μA) ( R 2 = 0.9981), and i pc (μA) = −0.07365 ν (mV s −1 ) + 0.2846 (μA) ( R 2 = 0.999), confirming the reaction as a surface-confined process. 55 …”

Electrochemical Sensing of Curcumin: A Review

“…A summary of electrochemical sensors for curcumin quantitative analysis in natural and biological matrixes is presented in Table 1. 4.9 × 10 −6 artificial capsaicin (N-vanillylnonanamide) [48] p(Van-CA)/Pt DPV 1.0 × 10 −5 -7.0 × 10 −5 5.0 × 10 −6 turmeric powder, curry powder [49] e-rGO/GCE DPV 2.0 × 10 −7 -6.0 × 10 −5 1.0 × 10 −7 commercial turmeric capsules [24] CQDs/GCE DPV 4.0 × 10 −7 -2.0 × 10 −4 1.0 × 10 −7 turmeric powder [50] NiCl 2 /GCE DPV 1.0 × 10 −6 -6.0 × 10 −4 1.1 × 10 −7 human blood serum [51] PAr-CNTPE DPV 2.0 × 10 −7 -5.0 × MIP-CPE CV 1.0 × 10 −7 -5.0 × 10 −5 1.0 × 10 −8 curcuma powder, curcuma cookies [54] SDS-CPE DPV 2.0 × 10 −7 -1.0 × 10 −6 1.0 × 10 −6 -4.5 × 10 −6 2.0 × 10 −8 food supplement [55] PG-CNTPE DPV 4.0 × 10 −7 -6.0 × 10 −6 6.0 × 10 −6 -1.0 × 10 −5 2.8 × 10 −8 food supplement [56] Al 3+ /Pd NPs/GE SWV 3.0 × 10 −8 -6.0 × 10 −7 2.2 × 10 −8 turmeric powder [18] Gr/GCE LSV 5.0 × 10 −8 -3.0 × 10 −6 3.0 × 10 −8 Curcuma longa L.…”