A novel role for melatonin: regulation of the expression of cell adhesion molecules in the rat hippocampus and cortex

Baydaş, Gıyasettin; Nedzvetsky, V. S.; Nerush, P. A.; Кириченко, С. В.; Demchenko, H.M.; Reiter, R. J.

doi:10.1016/s0304-3940(02)00328-2

Cited by 47 publications

(30 citation statements)

References 23 publications

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“…The obtained results demonstrated a slower cognitive decline and less diminution of autonomy in those who received phototherapy and melatonin. According to Baydas et al [51], melatonin has a modulatory effect on the expression of neural cell adhesion molecule (NCAM) in brain areas involved with cognitive function. Melatonin may be involved in structural remodeling of synaptic connections during memory and learning processes.…”

Section: Discussionmentioning

confidence: 99%

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

et al. 2014

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BackgroundRecurrent depressive disorder is a multifactorial disease; one of the typical features is cognitive impairment. The purpose of this study was analysis of ASMT gene expression both on mRNA and protein levels in patients with recurrent depressive disorder (rDD) and assessment of the relationship between plasma level of ASMT protein, gene expression on mRNA level, and cognitive performance.Material/MethodsThe study included 236 subjects: patients with rDD (n=131) and healthy subjects (n=105, CG). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test (VFT), and Auditory Verbal Learning Test (AVLT).ResultsBoth mRNA and protein expression levels of ASMT gene were significantly higher in healthy subjects when compared to rDD. The average ASMT mRNA expression level measured for the entire group was M=0.21 (SD=0.09), and the protein level was M=12.84 (SD=3.29). In patients with rDD, statistically significant correlations occurred between both mRNA and protein expression levels and part A of the TMT (negative correlation) and verbal fluency test (positive correlation). In the group CG, there was no statistically significant association between the analyzed variables. In the entire group there was a statistically significant correlation between both ASMT mRNA and protein expression levels and all the neuropsychological tests used in the survey.Conclusions1. Our study confirms previous results showing decreased mRNA and protein expression levels of ASMT gene in depression. 2. Our data suggest a relationship between decreased mRNA and protein expression levels of ASMT gene and cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

et al. 2014

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“…Alternatively, the effects of melatonin may be through the direct modulation of memory formation circuits. Melatonin has shown to play an important role in structural remodeling of synaptic connections during memory and learning processes [45]. Other researches also demonstrated the ability of melatonin to modulate neuronal firing in the hippocampus and other brain regions [46, 47].…”

Section: Discussionmentioning

confidence: 99%

Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats

et al. 2014

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BackgroundPrevious studies have shown that melatonin is involved in the processes that contribute to learning and memory. At present study, we tested the effects of exogenous melatonin (2.5 mg/kg) on the acquisition, expression and extinction of cued fear in rats.ResultsResults showed that a single afternoon administration 30 min before conditioning has no effect on the acquisition of cued fear. Compared to rats injected with vehicle, rats injected with melatonin 30 min before extinction training presented a significant lower freezing during both extinction training and extinction test phases, however, freezing response did not differ for the initial four trials during extinction training. Melatonin injected immediately after extinction training was ineffective on extinction learning.ConclusionsThese results suggest that melatonin, at the dose applied in this study, facilitates the extinction of conditional cued fear without affecting its acquisition or expression, and melatonin facilitates cued fear extinction only when it is present during extinction training. These findings extend previous research on the melatonin effects on learning and memory and suggest that melatonin may serve as an agent for the treatment of anxiety disorders such as posttraumatic stress disorder (PTSD).

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“…Some studies have provided evidence for its direct effect. For instance, a research has suggested that melatonin could be involved in structural remodelling of synaptic connections during memory and learning processes (Baydas et al 2002). Other research has also suggested that melatonin may influence memory formation in the hippocampus (El Sherif et al 2003).…”

Section: Discussionmentioning

confidence: 99%

The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

Karakaş

Coşkun

Kaya

2011

Biological Rhythm Research

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Melatonin is the main hormone of the pineal gland that informs the body about the environmental light and darkness regimen and is considered to regulate many important physiological and behavioural activities. In the present study, we examined the effects of pinealectomy, constant-release melatonin implants and timed melatonin injections on spatial memory in male Wistar rats by using Morris water maze. Pinealectomy, melatonin injection and melatonin implantation were performed on groups, including controls for all groups. After a week of the pinealectomy and melatonin implantation surgeries, we applied the injections and made the training trials throughout 4 days. At the fifth day, experiments were performed and recorded. Spatial memory performance of the rats was impaired by the pinealectomy and melatonin injections, since they elongated the latency and shortened the time passed in the correct quadrant. Melatonin implantation did not affect the spatial memory performance of the rats. The latency and the time passed in correct quadrant were not statistically different from their controls. The results suggest that while the removal of the pineal gland and exogenous administration of melatonin via injections are causing impairment, constantrelease melatonin administration via implantation does not affect the spatial memory in Wistar albino rats.

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A novel role for melatonin: regulation of the expression of cell adhesion molecules in the rat hippocampus and cortex

Cited by 47 publications

References 23 publications

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats

The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

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