ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

Talarowska, Monika; Szemraj, Janusz; Zajączkowska, Marlena; Gałecki, Piotr

doi:10.12659/msm.890160

Cited by 22 publications

(13 citation statements)

References 52 publications

(52 reference statements)

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“…The possible causes of the reduction in MT level can be attributed either to the central and peripheral alterations in serotonin levels in autism that were widely reported previously 2 or to the defect in the synthesis of MT. 23 Previous studies 8 , 23 of MT production in autistic disorder were also limited by small sample sizes and were not entirely consistent, but all reported an abnormal MT production, 2 which is inconsistent with the results of the current study.…”

Section: Discussioncontrasting

confidence: 92%

Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children

Abdulamir

Abdul‐Rasheed

Abdulghani

2016

SMJ

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Objectives:To test the possible association between oxytocin and melatonin levels with the severity of social and cognitive dysfunctions, and to study the correlation between these parameters in children with autism.Methods:A case-control study was carried out in the Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq. The study was performed on 60 male autistic patients recruited from the Pediatric Department of Al-Sader General Hospital, Baghdad, Iraq between November 2014 and April 2015. The levels of oxytocin and melatonin were measured in the serum of these autistic male patients, and categorized as mild, moderate, and severe (20 patients each), and was compared with 26 age- and gender-matched control subjects.Results:The data indicated that the levels of oxytocin (44.72 ± 36.1 µIU/mL) and melatonin in patients (23.08 ± 10.41 pg/mL) were significantly lower (p<0.05) than that of age-matched (102.1 ± 34.31 µIU/mL) and gender-matched controls (53.05 ± 38.38 pg/mL). These parameters were remarkably associated with the severity of the disease that was indicated by the significant decrease in the levels of oxytocin (47 ± 25.47 µIU/mL) and melatonin in moderate (20 ± 6.14 pg/mL), and patients with severe oxytocin (27.92 ± 10.23 µIU/mL) and patients with severe melatonin (21.69 ± 7.02 pg/mL) when compared with mild autistic patients with oxytocin (59.22 ± 27.32 µIU/mL) and melatonin (27.55 ± 14.71 pg/mL). These 2 parameters showed a significant positive correlation with each other in moderate (r=0.513; p=0.021), and severe patients (r=0.598; p=0.005).Conclusion:Receiver operating characteristic analysis revealed that oxytocin can be considered as a good diagnostic marker in severe autistic patients while melatonin can be considered as a good diagnostic marker in all autistic subgroups. This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.

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Section: Discussioncontrasting

confidence: 92%

Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children

Abdulamir

Abdul‐Rasheed

Abdulghani

2016

SMJ

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“…To our knowledge, there are only 2 studies in the literature that characterize mRNA expression of ASMT in the peripheral blood of recurrent DD. Galecki et al [74] and Talarowska et al [83] have demonstrated the reduced mRNA expression of ASMT in patients with depression and cognitive impairment. Surprisingly, these studies, despite promising results, have not been replicated.…”

Section: Melatonin Related-gene Expression Profile In Depressionmentioning

confidence: 99%

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

Dmitrzak‐Węglarz

Reszka

2017

Neuropsychobiology

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Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body’s circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood. Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin, SNAT, and ASMT are key melatonin level regulation factors. Melatonin acts mainly on the MT₁ and MT₂ receptors, which are present in the SCN, to regulate physiological and neuroendocrine functions including circadian entrainment, referred to as a chronobiotic effect. Although melatonin has been known about and refereed to for almost 50 years, the relationship between melatonin and depression is still not clear. In this review, we summarize current knowledge about the genetic and epigenetic regulation of enzymes involved in melatonin synthesis and metabolism as potential features of depression pathophysiology and treatment. Confirmation that melatonin metabolism in peripheral blood partially reflects a disorder in the brain could be a breakthrough in the standardization of measurements of melatonin level for the development of treatment standards, finding new therapeutic targets, and elaborating simple noninvasive clinical tests.

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“…Although most studies indicate that general intelligence remains intact in patients with MS, other investigations have detected slight but significant decreases. Overt dementia is rare in MS, and the most common clinical presentation is specific and subtle cognitive deficits that can vary substantially among patients [ 3 , 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

The BICAMS Battery for Assessment of Lithuanian-Speaking Multiple Sclerosis Patients: Relationship with Age, Education, Disease Disability, and Duration

2015

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BackgroundAssessment of cognitive impairment (CI) in multiple sclerosis (MS) patients is very useful, but it requires time-consuming expert evaluation with specialized materials. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was created as a brief and specific instrument for the evaluation of CI.The aims of this study were to assess the cognitive status of MS patients by using the Lithuanian version of BICAMS, to evaluate the test-retest reliability of the Lithuanian version of BICAMS, and to measure the impact of CI on disability and duration of MS.Material/MethodsWe enrolled 50 MS patients and 20 cognitively normal control subjects, matched for age, gender, and level of education. Cognitive functions were assessed by the BICAMS tests, which include the Symbol Digit Modalities Test, the Brief Visuospatial Memory Test Revised, and the California Verbal Learning Test, 2nd edition.ResultsMS patients performed significantly worse than controls on the 3 neuropsychological tests of BICAMS (p<0.001). Younger and intellectually employed persons performed significantly better on these tests than older persons, manual workers, or unemployed persons (p<0.05). MS patients with higher disability scores tended to perform worse on the tests (p<0.05), but we found no relationship between BICAMS test scores and the duration of the disease or relapse rate (p>0.05). Test-retest reliability was excellent for all 3 subtests (r>0.8, p<0.05).ConclusionsOur study shows that BICAMS is a valid and acceptable cognitive assessment tool that can be recommended for routine use in Lithuania for assessing patients with MS.

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ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

Cited by 22 publications

References 52 publications

Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children

Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

The BICAMS Battery for Assessment of Lithuanian-Speaking Multiple Sclerosis Patients: Relationship with Age, Education, Disease Disability, and Duration

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