A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery

Boztepe, Osman Fatih; Gün, Taylan; Demir, Meltem; Gür, Özer Erdem; Özel, Deniz; Doğru, Harun

doi:10.1007/s00405-015-3753-z

Cited by 30 publications

(20 citation statements)

References 21 publications

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“…A recent preliminary investigation conducted by our own research group also showed a significant direct association between CRSwNP recurrence rates and serum basophil counts . When the neutrophil‐to‐lymphocyte ratio (NLR) was investigated vis‐a‐vis CRSwNP recurrence after surgery, it was found to be significant higher in patients whose disease recurred than in those remaining disease‐free . Yenigün also found that patients with recurrent polyposis had a significantly higher preoperative eosinophil‐to‐lymphocyte ratio (ELR) than patients remaining recurrence‐free.…”

mentioning

confidence: 88%

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Brescia

Barion

Zanotti

et al. 2016

Int Forum Allergy Rhinol

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mentioning

confidence: 88%

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Brescia

Barion

Zanotti

et al. 2016

Int Forum Allergy Rhinol

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“…14,15 Boztepe et al reported that in patients with chronic sinusitis who underwent endoscopic sinus surgery, the sensitivity was 39.4% and the specificity was 88.9% for PLR. 16 Zhang et al reported a sensitivity of 76.9% and a specificity of 41.6% for NLR in patients with neutrophilic asthma. 17 In addition, several researchers have investigated these parameters as activation criteria for Behcet's disease, obstructive sleep apnoea syndrome (OSAS), chronic obstructive pulmonary disease (COPD), infective endocarditis and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Inflammation in Allergic Rhinitis

Gürlek¹,

Tasdemir²

2017

Turkiye Klinikleri J Intern Med

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Biomarkers of Inflammation in Allergic Rhinitis A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Allergic rhinitis is one of the most common atopic diseases. The skin prick test and the allergen-specific IgE antibody test are used for its diagnosis. The aim of this study was to identify the presence of allergic inflammatory parameters with prognostic value, which are easily accessible, simple and inexpensive, to make them available for clinical use. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included people with and without allergic rhinitis between the ages of 18-55 years who were admitted to the Internal Medicine and Allergy and Clinical Immunology polyclinics. Those without a known disease were included in the healthy group. People who did not receive any immunotherapy, were identified as allergic by skin prick tests and had no other disease were included in the allergic rhinitis group. Data were obtained retrospectively by screening the patients' files, and hence patient approval was not required in this study. R Re es su ul lt ts s: : The allergic rhinitis group comprised 114 (62.6%) females and 68 (37.4%) males, with a mean age of 31.37±9.89 years. The healthy group consisted of 50 (56.2%) males and 39 (43.8%) females, with a mean age of 31.93±10.87 years. In the allergic rhinitis group, while the eosinophil count (p=0.042), eosinophil-lymphocyte ratio (ELR) (p=0.007) and plateletlymphocyte ratio (PLR) (p=0.007) were found to be significantly high, the median platelet volume (MPV) was found to be significantly low (p<0.001). MPV measurements were significantly lower in the allergic rhinitis group (p<0.001). For MPV, the sensitivity was 64.84%, the specificity was 65.17%, the positive predictive value (PPV) was 79.20% and the negative predictive value (NPV) was 47.50%. For PLR (p=0.005), the sensitivity was 61.54%, the specificity was 59.55%, the PPV was 75.70% and the NPV was 43.10%. For ELR (p=0.005), the sensitivity was 48.90%, the specificity was 74.16%, the PPV was 79.50% and the NPV was 41.50%. C Co on nc cl lu us si io on n: : MPV, PLR and ELR do not directly indicate a single disease. We suggest that it is particularly important in primary health care to take a complete blood count in clinical practice to direct the patient to an allergy centre. Skin prick testing and allergen-specific IgE screening will be appropriate to confirm allergic rhinitis in suspected cases. We believe that a more extensive study is needed in this regard. K Ke ey yw wo or rd ds s: : Rhinitis, allergic, perennial; blood platelets; eosinophils Ö ÖZ ZE ET T A Am ma aç ç: : Allerjik rinit en sık rastlanılan atopik hastalıktır. Tanısında deri prick ve allerjen spesifik IgE testleri kullanılır. Çalışmanın amacı allerjik inflamasyonu gösteren ulaşılabilir, kolay, ucuz, prognostik olarak da değer taşıyan parametrelerin varlığını saptamak ve kullanıma sunulmasına katkıda bulunmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : İç Hastalıkları ile Allerji ve Klinik İmmunoloji poliklinikleri...

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“…9,25 Furthermore, there are also studies suggesting that PLR is a predictive marker in nasal polyposis cases. 12 Considering that another topic in ACP etiology is chronic sinusitis and inflammation, there may be changes in the inflammatory blood parameters of these patients. In our study, there was no statistically significant difference between the pediatric ACP cases and the control group in terms of the specified parameters (p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…11 Moreover, there are also studies suggesting that these parameters may be considered as an indicator for recurrence in cases of nasal polyposis. 12 Furthermore, in cases of obstructive pathology, it is suggested that especially mean platelet volume (MPV) and PLR ratios show an alteration in children and adults, and this is also a risk factor for possible cardiovascular complications. 13,14 Based on these studies, we considered that the hemogram parameters could vary in cases of pediatric ACPs due to the severity of inflammation and nasal obstruction.…”

Section: Introductionmentioning

confidence: 99%

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Korkmaz

Çelik

Turan

et al. 2020

Int Arch Otorhinolaryngol

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Introduction There are no definitive parameters to guide the etiology and severity of pediatric antrochoanal polyps. Objective The aim of our study is to compare the values of blood cell distribution parameters in cases of pediatric antrochoanal polyps (ACPs) with those of the control group. These values may be guiding parameters in determining the etiology of ACPs and evaluating the severity of the disease and the risk of recurrence. Methods Blood count values of patients operated for pediatric ACPs were retrospectively analyzed and compared with the data of the control group with the same age and gender distribution. The ACPs group was divided into subgroups in terms of inflammation, severity, and recurrence, and these subgroups were statistically compared as well. Results When the ACP patient group and the control group were compared, there was no statistically significant difference between the two groups. When we compared the patients considering the CT findings, there was a statistically significant difference between the stage III patients and the control group in terms of mean platelet volume (MPV) and platelet-to-lymphocyte ratio (PLR) values (p < 0.05 in both). Similarly, the MPV and PLR values were significantly higher in the recurrence patient group than in the control group. (p < 0.05 in both). Conclusion As a result of the data obtained, it can be suggested that inflammatory parameters in pediatric cases of ACPs vary in terms of recurrence and the severity of the disease.

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A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery

Cited by 30 publications

References 21 publications

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Biomarkers of Inflammation in Allergic Rhinitis

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

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