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Background Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients.Material and methods A total of 93 diabetic and 37 non-diabetic participants were included into the study. Aspirin resistance was measured with a whole-blood desktop platelet function analyzer (PFA-100) with an epinephrine agonist.Results Altogether 41.9% patients with DM were aspirin non-responders. Aspirin resistance was observed in 43.2% of non-diabetic patients (p = 0.89). Presence of diabetes mellitus had no effect on aspirin response (RR 0.95 (95% CI 0.44–2.05), p = 0.89) in the whole study population. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17–8.16), p = 0.023).Conclusion The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients.

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Background: Drug hypersensitivity reactions are considered public health problems due to associated morbidity and socioeconomic costs. The evaluation of health-related quality of life in patients with drug hypersensitivity is still a widely unconsidered topic. The aim of our study is to reveal the effects of drug allergy on the quality of life of patients who apply to our outpatient clinic with the complaint of drug allergy.Methods: This study is prospective a questionnaire study under supervision. Patients who applied to the University of Health Sciences, Bursa Postgraduate Research and Training Hospital Department of Allergy outpatient clinic between August 2019 and May 2020 with the complaint of drug allergy filled out the quality of life questionnaire (DrHy-Q), and short questionnaire of psychological well-being index (PGWBIs) under the supervision of a specialist physician before the diagnostic procedures.Results: The study was conducted with 150 cases and 73.3 % (n=110) of the cases were female and 26.7% (n=40) were male. No significant correlation was found between the demographic characteristics of the patients, the observed symptoms, the culprit drugs, familial and individual comorbid and psychological diseases, and DrHY-Q (p>0.05). DrHY-Q was only affected from the type of allergic reaction. A negative statistically significant weak correlation was also detected between the total DrHY-Q score and the PGWBI total score (r: -0.283; p<0.01).Conclusions: We found that DrHY-Q is sensitive to reaction type and able to discriminative type 1 and type 2 reactions (p=0.017; p<0.05). We think that more comprehensive studies are needed on this subject.

Background: The use of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) is an important problem for clinicians who treat coronavirus disease (COVID-19) in patients with hypertension. The aim of the study was to reduce the confusion in this matter to some extent.Methods: This study was carried out in the Health Sciences University, Bursa High Specialization Training and Research Hospital between 23 March to 23 June 2020. Patients were evaluated using thorax computed tomography (CT) taken during hospitalization with severity and risk scoring, confusion, uraemia, respiratory rate, blood pressure, age ≥65 years, score >2 (CURB-65) for pneumonia.Results: The rate of severe pneumonia was significantly higher in the group using ACEI and ARBs. CURB 65 high risk observation rate was significantly higher in the group with ACEI and ARB using. The rate of severe pneumonia observed was significantly higher in the any antihypertensive drugs using group. This risk height is more pronounced in those using ACEI and ARBs. The mortality rate of our 500 patients with COVID-19 was 2.2% (11/500). There was no history of hypertension in these 4 patients, but 1 (1/4) of these 4 patients had diabetes. Six patients were taking ACEI and/or ARB in combination with their diuretic, calcium channel blocker and beta blocker. Only one patient was taking calcium channel blocker and beta blocker.  Conclusions: The risk of severe pneumonia may increase in COVID-19 positive patients using any antihypertensive drug. It was more pronounced in those using ACEI and ARB. We believe that more comprehensive studies are needed in this about.

Biomarkers of Inflammation in Allergic Rhinitis A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Allergic rhinitis is one of the most common atopic diseases. The skin prick test and the allergen-specific IgE antibody test are used for its diagnosis. The aim of this study was to identify the presence of allergic inflammatory parameters with prognostic value, which are easily accessible, simple and inexpensive, to make them available for clinical use. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included people with and without allergic rhinitis between the ages of 18-55 years who were admitted to the Internal Medicine and Allergy and Clinical Immunology polyclinics. Those without a known disease were included in the healthy group. People who did not receive any immunotherapy, were identified as allergic by skin prick tests and had no other disease were included in the allergic rhinitis group. Data were obtained retrospectively by screening the patients' files, and hence patient approval was not required in this study. R Re es su ul lt ts s: : The allergic rhinitis group comprised 114 (62.6%) females and 68 (37.4%) males, with a mean age of 31.37±9.89 years. The healthy group consisted of 50 (56.2%) males and 39 (43.8%) females, with a mean age of 31.93±10.87 years. In the allergic rhinitis group, while the eosinophil count (p=0.042), eosinophil-lymphocyte ratio (ELR) (p=0.007) and plateletlymphocyte ratio (PLR) (p=0.007) were found to be significantly high, the median platelet volume (MPV) was found to be significantly low (p<0.001). MPV measurements were significantly lower in the allergic rhinitis group (p<0.001). For MPV, the sensitivity was 64.84%, the specificity was 65.17%, the positive predictive value (PPV) was 79.20% and the negative predictive value (NPV) was 47.50%. For PLR (p=0.005), the sensitivity was 61.54%, the specificity was 59.55%, the PPV was 75.70% and the NPV was 43.10%. For ELR (p=0.005), the sensitivity was 48.90%, the specificity was 74.16%, the PPV was 79.50% and the NPV was 41.50%. C Co on nc cl lu us si io on n: : MPV, PLR and ELR do not directly indicate a single disease. We suggest that it is particularly important in primary health care to take a complete blood count in clinical practice to direct the patient to an allergy centre. Skin prick testing and allergen-specific IgE screening will be appropriate to confirm allergic rhinitis in suspected cases. We believe that a more extensive study is needed in this regard. K Ke ey yw wo or rd ds s: : Rhinitis, allergic, perennial; blood platelets; eosinophils Ö ÖZ ZE ET T A Am ma aç ç: : Allerjik rinit en sık rastlanılan atopik hastalıktır. Tanısında deri prick ve allerjen spesifik IgE testleri kullanılır. Çalışmanın amacı allerjik inflamasyonu gösteren ulaşılabilir, kolay, ucuz, prognostik olarak da değer taşıyan parametrelerin varlığını saptamak ve kullanıma sunulmasına katkıda bulunmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : İç Hastalıkları ile Allerji ve Klinik İmmunoloji poliklinikleri...

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