A novel polymorphism of the myogenin gene is associated with body measurement traits in native Chinese breeds

Xue, Mei; Zan, Linsen; Gao, Li; Wang, H.B.

doi:10.4238/2011.november.4.6

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…Through marker-assisted selection studies, many important genes have been identified that have roles in controlling growth (Xue et al, 2011;Tian et al, 2011) and meat quality in livestock (Jiao et al, 2010;Fan et al, 2011). Koo et al (2005) identified CRTC2 as a key regulator for the transcriptional activation of gluconeogenic enzyme, via phosphorylation-dependent cellular localization by AMP-activated protein kinase (AMPK) family of Ser/Thr kinases (Koo et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle

Xu¹,

Gui²,

Song³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Growth and meat quality traits play important roles in the evaluation of cattle productivity and are influenced by genetic and environmental factors. CRTC2 is a recently discovered gene related to obesity that may influence fat deposition. The aim of the current study was to detect polymorphisms of bovine CRTC2 and explore their relationships to growth and meat quality in Qinchuan cattle. Three single nucleotide polymorphisms (SNPs); g.3001 C>T; g.3034 G>A; and g.3467 T>C, were identified from sequencing results of 422 Qinchuan cattle. The genotypic distributions of both g.3034 G>A and g.3467 T>C mutations were in agreement with Hardy-Weinberg equilibrium, (P < 0.05), while the T3001C mutation was not (P > 0.05), based on χ 2 test analysis. The SNPs g.3001 C>T and g.3034 G>A are missense mutations (Ser/Phe and Ser/ 12913 SNPs in bovine CRTC2 and economic production traits ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12912-12920 (2015) Thr respectively). Additionally, SNPs g.3034 G>A and g.3467 T>C showed a medium polymorphism level (0.25 < PIC< 0.50), whereas g.3001 C>T showed a low polymorphism level (PIC < 0.25). These three SNPs were significantly associated with several growth and meat quality traits in the Qinchuan cattle population (P < 0.05 or P < 0.01). Collectively, these results demonstrate that CRTC2 is involved in the regulation of cattle growth and meat quality, and suggest that CRTC2 is a potential candidate gene for marker-assisted selection in future breeding development programs for Qinchuan cattle.

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Section: Discussionmentioning

confidence: 99%

Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle

Xu¹,

Gui²,

Song³

et al. 2015

Genet. Mol. Res.

Self Cite

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“…Through marker-assisted selection studies, many important genes have been identified to be involved in controlling growth (Xue et al, 2011;Tian et al, 2011) and meat quality in livestock (Jiao et al, 2010;Fan et al, 2011). Studies in mammalian cells have suggested that SIRT2 may play a role in cell cycle regulation and cytoskeleton organization by targeting the cytoskeletal protein tubulin (North et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle

Gui¹,

Yang²,

Zhao³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Silent information regulator 2 (SIRT2), a member of the Sirtuin family of class III nicotinamide adenine dinucleotidedependent protein deacetylases, plays an important role in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine SIRT2 gene and explore their relationships with meat quality and body measurement traits (BMTs) in Qinchuan cattle. Four single nucleotide polymorphisms (A7445G, C7711T, G17937A, and G20937A) in the fourth intron, fourth exon, ninth exon, and twelfth exon of the SIRT2 gene, respectively, were identified according to the sequencing results of 520 individuals of a Qinchuan cattle population. The genotypic distributions of both A7445G and G20937A were in agreement with the Hardy-Weinberg equilibrium (P < 0.05), whereas the other two mutations were not (0.05 < P < 0.01), based on the c 2 test. Association analysis indicated that the four loci were significantly correlated with several BMTs and meat quality traits. When in combination, the H 1 H 1 (AA-CC-GG-CC) diplotypes showed better BMT and meat quality traits than those by other combinations. 8835©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 8834-8844 (2014) SNPs in the bovine SIRT2 gene and economic traits Collectively, the results show that SIRT2 is involved in the regulation of the growth and meat quality of cattle, suggesting that the SIRT2 gene may be a candidate gene for marker-assisted selection in the development of future breeding programs for Qinchuan cattle.

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“…Growing observations indicate that genetic polymorphisms in myogenin gene are associated with growth traits in livestock. Xue et al [13] identified a novel polymorphism (T314C) in the myogenin gene that was associated with growth traits in native Chinese breeds. Anton et al [14] showed that one SNP in myogenin gene had a strong effect on growth rate in Hungarian large pig.…”

Section: Discussionmentioning

confidence: 99%

Çin Tibet Koyununda Myogenin Geninin Genetik Polimorfizmi ve Büyüme Özellikleriyle Olan İlişkisi

Sun¹,

Han²

2017

Kafkas Univ Vet Fak Derg

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Myogenin gene encodes for skeletal muscle-specific transcription factors with highly conserved basic helix-loop-helix domain and play key role in growth and muscle development. In this study, the polymorphisms of myogenin gene were investigated to check whether they are associated with growth traits in Chinese-Tibetan sheep. In three sheep breeds with a total number of 632 individuals, three SNPs, including two in exon 1 (C109A and C183T) and one in intron 2 (A1403C) were found by DNA sequencing. Among those, C109A is a missense mutation (Gly37Arg). The single marker association analysis showed that the three mutations were significantly associated with growth traits (at P<0.01 or P<0.05). In conclusion, our results suggest that myogenin gene variation may be considered molecular markers for growth traits in Chinese-Tibetansheep. Keywords: Chinese Tibetan sheep, Myogenin gene, SNP, Growth traits Çin Tibet Koyununda Myogenin Geninin Genetik Polimorfizmi ve Büyüme Özellikleriyle Olan İlişkisi ÖzetMyogenin geni oldukça korunaklı olan temel heliks-ilmek-heliks domain yapısında olup iskelet kas-spesifik transkripsiyon faktörlerini kodlar ve büyüme ile kas gelişimde önemli rol oynar. Bu çalışmada, myogenin geninin polimorfizmi ve Çin-Tibet koyununda büyüme özellikleri ile ilgisinin olup olmadığı araştırıldı. Üç koyun ırkından oluşan toplam 632 hayvanda, DNA sekansı ile ikisi ekzon 1 (C109A ve C183T) ve biri intron 2 (A1403C)'de olmak üzere üç SNP bulundu. Bunlar arasında C109A missen mutasyonuydu (Gly37Arg). Tek markır asosiasyon analizi, üç mutasyonun anlamlı derecede büyüme özellikleri ile ilişkili olduğunu gösterdi (P<0.01 veya P<0.05). Sonuç olarak, elde edilen sonuçlar ışığında myogenin gen varyasyonunun Çin-Tibet koyununda büyüme özellikleri için moleküler belirteç olabileceği saptandı.

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A novel polymorphism of the myogenin gene is associated with body measurement traits in native Chinese breeds

Cited by 12 publications

References 26 publications

Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle

Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle

Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle

Çin Tibet Koyununda Myogenin Geninin Genetik Polimorfizmi ve Büyüme Özellikleriyle Olan İlişkisi

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