A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography

Zhang, Haiyang; Ou, Junjie; Wei, Yinmao; Wang, Hongwei; Chen, Lianfang; Zou, Hanfa

doi:10.1016/j.aca.2015.04.001

Cited by 29 publications

(10 citation statements)

References 46 publications

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“…As a result of the mixed polar/non polar groups and ease of preparation/functionalization, methacrylate monoliths have been prepared for a number of different methods of chromatographic separation, such as ion exchange [44], Hydrophilic Interaction Liquid Chromatography (HILIC) [45], and Reverse Phase [38]. This includes application for the separation of proteins and peptides [27], polymer separations [46,47] as well as alkyl benzenes and other small polar molecules [48,49,50]. …”

Section: Methacrylate Polymer Monolithsmentioning

confidence: 99%

Methacrylate Polymer Monoliths for Separation Applications

Groarke

Brabazon

2016

Materials

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This review summarizes the development of methacrylate-based polymer monoliths for separation science applications. An introduction to monoliths is presented, followed by the preparation methods and characteristics specific to methacrylate monoliths. Both traditional chemical based syntheses and emerging additive manufacturing methods are presented along with an analysis of the different types of functional groups, which have been utilized with methacrylate monoliths. The role of methacrylate based porous materials in separation science in industrially important chemical and biological separations are discussed, with particular attention given to the most recent developments and challenges associated with these materials. While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. Conclusions regarding this previous work are drawn and an outlook towards future challenges and potential developments in this vibrant research area are presented. Discussed in particular are the potential of additive manufacturing for the preparation of monolithic structures with pre-defined multi-scale porous morphologies and for the optimization of surface reactive chemistries.

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Section: Methacrylate Polymer Monolithsmentioning

confidence: 99%

Methacrylate Polymer Monoliths for Separation Applications

Groarke

Brabazon

2016

Materials

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“…Highly cross‐linked porous polymer monoliths were prepared by copolymerization of multiacrylate cross‐linker (dipentaerythritol penta‐/hexa‐acrylate) and lauryl methacrylate by photo‐initiated free‐radical polymerization within 5 min in the presence of ethylene glycol and hexyl alcohol as porogenic solvents . The total concentration of the monomers as well as the concentration of the cross‐linker in the polymerization mixture has been optimized.…”

Section: Polymer Monoliths For Separation Of Small Moleculesmentioning

confidence: 99%

Current trends in the development of porous polymer monoliths for the separation of small molecules

Urban

2015

J of Separation Science

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Since their introduction, the main application area of porous polymer monoliths has been in the fast gradient separation of synthetic and natural polymers. On the other hand, it has proven to be difficult to prepare polymer monoliths providing column efficiency comparable with particulate and monolithic silica-based stationary phases. During this decade, several experimental approaches were performed that aimed to improve this property of polymer monoliths. These protocols include variation in a polymerization time and preparation of monolithic stationary phases at limited conversion of the polymerization reaction, application of novel, highly ordered, nanomaterials, and/or hypercross-linking surface modification controlling the cross-link density of prepared monoliths. By using some of these approaches, monolithic stationary phases with column efficiency reaching 200,000 plates/m for low-molecular-weight compounds have been prepared. This review deals with preparation of polymer monoliths for the separation of small molecules and summarizes recent development in this field. At first, it focuses on monolithic columns morphology and repeatability of their preparation. Then, recent results in individual experimental protocols are discussed. Finally, possible future steps leading to the preparation of more efficient monolithic stationary phases are outlined.

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“…Although polymer‐based monolithic columns have been widely studied and well used in macromolecules, it is yet a challenge to solve the inability of organic polymer monoliths to separate small molecules, which limiting their advantages used in further applications of real samples. Numerous studies focused on development of polymer monoliths for efficient separation of small molecules are mostly reported by using capillary column . As we know, disadvantage of capillary column is poor repeatability, especially for complex sample such as Chinese herb.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

Jiang

Jiao

Zhang

et al. 2017

J of Applied Polymer Sci

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A polymer monolithic column was prepared via redox system in a stainless steel column (50 3 4.6 mm i.d.) by using 1,6hexanediol diacrylate as monomer and ethylene dimethacrylate as cross linking agent. Characteristics of the homemade monolithic column were investigated by scanning electron microscopy, nitrogen adsorption-desorption and mercury intrusion porosimeter, respectively. The results showed that the resulting monolithic column occupied relative uniform porous skeleton structure. Furthermore, the monolith was tested by separating aromatic compounds in conjunction of high performance liquid chromatography with the highest column efficiency of more than 21,000 plate per meter, which was relative high for polymer-based monolithic column with 4.6 mm i.d. At last, the monolithic column was used to simultaneously separate and quantitatively analyzes five active compounds in Chinese herb Rheum palmatum L. The validation of the method was carried out, which indicated that the accuracy represented by recovery was in the range of 98.48% to 101.57%. Limit of detection and limit of quantification for the five active compounds were less than 33.7 ng and 90.8 ng, respectively. All the results indicated that the present method was simple and efficient for quantitative analysis of the five active compounds from Chinese herb Rheum palmatum L.

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A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography

Cited by 29 publications

References 46 publications

Methacrylate Polymer Monoliths for Separation Applications

Methacrylate Polymer Monoliths for Separation Applications

Current trends in the development of porous polymer monoliths for the separation of small molecules

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

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