Methacrylate Polymer Monoliths for Separation Applications

Abstract

This review summarizes the development of methacrylate-based polymer monoliths for separation science applications. An introduction to monoliths is presented, followed by the preparation methods and characteristics specific to methacrylate monoliths. Both traditional chemical based syntheses and emerging additive manufacturing methods are presented along with an analysis of the different types of functional groups, which have been utilized with methacrylate monoliths. The role of methacrylate based porous materials in separation science in industrially important chemical and biological separations are discussed, with particular attention given to the most recent developments and challenges associated with these materials. While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. Conclusions regarding this previous work are drawn and an outlook towards future challenges and potential developments in this vibrant research area are presented. Discussed in particular are the potential of additive manufacturing for the preparation of monolithic structures with pre-defined multi-scale porous morphologies and for the optimization of surface reactive chemistries.

Temperature effects on retention and efficiency of butyl and lauryl acrylate porous polymer monoliths in capillary electrochromatography

“…Over the last few years there have been several excellent reviews on the types of stationary phases that are used in CEC [1][2][3][11][12][13]. Surveyed studies utilized both commercially available and in-house designed stationary phases.…”

“…Needing no retaining frits, having a very open and highly permeable structure, and easily manipulated polymerization chemistry means that they have a number of features that can be explored, exploited, and optimized for their use as stationary phases. Many of their properties make these materials well suited for use in microchip systems . The ability to incorporate charged moieties also means that they can be readily adapted for use in CEC.…”

Synthesis and Characterisation of a Monolithic Imprinted Column Using a Methacrylic Acid Monomer with Porogen Propanol for Atenolol Analysis

“…e components used for the construction of imprinted monolithic columns are functional monomers, crosslinkers, porogens, and initiators. e functional monomer used in the present study was methacrylic acid (MAA), which is a universal monomer most often used for the manufacture of monolithic columns [18]. In addition, atenolol is alkaline, based on a pKa value of 9.6 [19]; thus, the imprinted atenolol column can be synthesised using MAA.…”

Eco-friendly production of metal nanoparticles immobilised on organic monolith for pepsin extraction

“…Additionally, nano-architectures can be used for introducing more surface functionalities to columns of polymeric monoliths 8,18,19 . Moreover, monolithic adsorbent electrical conductivity, chemical and thermal stabilities, and structural rigidity are easily altered using NPs to increase molecular interactions and other properties [20][21][22] . Besides, nanoparticles can extend the specifi c monolith adsorbent surface area for increase of test analyst retention that results in overall reactivity and enhanced selectivity within the adsorbent 22,23 .…”