A novel platform sensing based on combination of electromembrane-assisted solid phase microextraction with linear sweep voltammetry for the determination of tramadol

Fakhari, Ali Reza; Sahragard, Ali; Ahmar, Hamid; Tabani, Hadi

doi:10.1016/j.jelechem.2015.01.032

Cited by 35 publications

(19 citation statements)

References 42 publications

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“…Most probably, this was due to possible competitive extraction and pH shift in the EME acceptor phase. 28,29,36,37 Based on the results, we concluded that 15 min was the optimal extraction time to provide a clear group separation and high recovery, but longer time was needed if higher recoveries are preferable.…”

Section: Optimization Of Major Operational Parameters In a Series Ofmentioning

confidence: 98%

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

et al. 2015

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Electromembrane extraction (EME) and liquid-phase microextraction (LPME) were combined in a single step for the first time to realize simultaneous and clear group separation of basic and acidic drugs. Using 2-nitrophenyl octyl ether as the supported liquid membrane (SLM) for EME and dihexyl ether as the SLM for LPME, basic and acidic drugs were extracted and separated simultaneously from a low pH sample by EME and LPME, respectively. After 15 min of extraction, basic drugs (citalopram and sertraline) were exhaustively extracted, whereas the recoveries for acidic drugs (ketoprofen and ibuprofen) were in the range of 76%-86%. Longer extraction time provided higher recoveries for the acidic drugs, but this somewhat deteriorated the group separation. Matrices effects from the coexisting acidic drugs/basic drugs were tested, and we observed that simultaneous EME/LPME was not affected by coexisting drugs at high concentration. This approach was further investigated from human plasma. Extraction recoveries were strongly dependent on dilution of plasma with buffer and on extraction time. Finally, this simultaneous EME/LPME approach was evaluated in combination with liquid chromatography (LC)-MS. The linearity ranges for the basic and acidic drugs were 10-600 ng/mL and 1-60 μg/mL, respectively, with R(2) > 0.997 for all analytes. The repeatability at three different levels for all analytes was less than 15%. The limits of quantification (LOQ, S/N = 10) were found to be 4.0-6.3 ng/mL and 0.6-0.9 μg/mL for basic and acidic drugs, respectively. Simultaneous EME/LPME enabled efficient group separation of basic and acidic analytes under optimum experimental conditions for both EME and LPME.

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Section: Optimization Of Major Operational Parameters In a Series Ofmentioning

confidence: 98%

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

et al. 2015

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“…A literature survey revealed that several methods have been reported for the determination of TRM either alone or in the presence of other co‐formulated materials. These include spectrophotometric (Abdellatef, ; Amin, Adawy, Ali, & El‐Shahatt, ; Dhumal, Bhusari, Ghante, & Jain, ; Glavanović, Glavanović, & Tomišić, ; Lakshmi, Ravisankar, Kumar, & Babu, ; Thomas & Sankar, ), spectrofluorimetric (Abdellatef, El‐Henawee, El‐Sayed, & Ayad, ; Smith, Manavalan, Kannan, & Rajendiran, ), chromatographic (Baconi, Stan, Abdul Jalil Ebrahim, Tuchila, & Balalau, ; Batool, Ahmed, & Rasheed, ; Desai, Captain, & Kamdar, ; Dhumal, Bhusari, Patra, Thareja, & Jain, ; Karunakaran, Navaneethan, & Elango, ; Kiarostami, Rouini, Mohammadian, Lavasani, & Ghazaghi, ; Ravisankar, Sridevi, & Kumari, ; Solomon, Anand, Shukla, Sivakumar, & Venkatnarayanan, ), electrochemical (Chitravathi & Munichandraiah, ; Deiminiat, Rounaghi, & Arbab‐Zavar, ; Fakhari, Sahragard, Ahmar, & Tabani, ; Ganjali, Razavi, Faridbod, Riahi, & Norouzi, ; Madrakian, Alizadeh, Bahram, & Afkhami, ) and electrophoresis (Cunha, Ribeiro, Muñoz, & Richter, ) methods in addition to the hyphenated methods where the chromatographic separations are coupled with the detection (El‐Sayed, Mohamed, Nasser, Button, & Holt, ; Haage, Kronstrand, Carlsson, Kugelberg, & Josefsson, ; Liu, Wang, Yu, Dong, & Yue, ; Tambe, Deodhar, & Prakya, ; Tanaka, Naito, Mino, & Kawakami, ; Yilmaz & Erdem, ). Thus, the aim of the present study was to develop a highly sensitive, rapid and accurate LC–MS/MS method for simultaneous quantitation of TRM and some expected co‐formulated compounds.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel LC–MS/MS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs: Application to counterfeit study

Abdel‐Megied

El‐Din

2019

Biomedical Chromatography

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Counterfeiting of pharmaceuticals has become a serious problem all over the world, particularly in developing countries. In the present work, a highly sensitive LC-MS/MS method was developed for simultaneous determination of tramadol hydrochloride in the presence of some suspected mislabeled drugs such as alprazolam, diazepam, chlorpheniramine maleate, diphenylhydramine and paracetamol. The prepared samples were analyzed on an API 4000 mass spectrometer using an Eclipse C 18 column (3.5 μm, 4.6 × 100 mm). The mobile phase consisting of 0.01% formic acid, acetonitrile and methanol (60:20:20 v/v/v) was pumped with an isocratic elution at a flow rate of 0.7 mL min −1 . The detection was achieved on a triple quadruple tandem mass spectrometer in multiple reaction monitoring mode. The proposed method was successfully validated according to International Conference on Harmonization guidelines with respect to accuracy, precision, linearity, limit of detection and limit of quantitation. The calibration linear range for tramadol hydrochloride, alprazolam, diazepam, chlorpheniramine maleate, diphenylhydramine and paracetamol was 5-500 ng mL −1 . The results revealed that the applied method is promising for the differentiation of genuine tramadol tablets from counterfeit ones without prior separation.

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“…Compared with the above‐mentioned analytic methods, electrochemical techniques show the advantages of simplicity, cost effectiveness, easy operation, low analysis time and acceptable sensitivity . On the other hand, electrochemical detection is a powerful alternative of other analytical techniques for monitoring the organic pollutants such as nitroaromatics .…”

Section: Introductionmentioning

confidence: 99%

Determination of 4‐Nitrobenzaldehyde in Water Samples by Combination of Switchable Solvent Based Microextraction and Electrochemical Detection on MWCNTs Modified Electrode

Ahmar

Shahvandi

2019

Electroanalysis

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A novel approach is presented to determine 4‐nitrobenzaldehyde in water samples. The procedure is based on switchable solvent based liquid‐liquid microextraction (SS‐LLME) and then determination by differential pulse voltammetry at multi‐walled carbon nanotubes modified glassy carbon electrode. Dipropylamine, a solvent with switchable polarity, was used as an extraction solvent that can be miscible/immiscible upon the changes of pH of sample solution. Effects of experimental conditions on SS‐LLME were investigated using a one‐factor‐at‐a‐time methodology. Under optimized conditions, a calibration curve was linear in the concentration range of 1.0 and 350 μg L−1. Limits of quantification and detection were empirically 1.0 μg L−1 and 0.3 μg L−1, respectively. Intraday and Interday RSDs%, calculated in three concentration levels, were in the range of 6.2–7.8 % confirm the proper precision of the method. Finally, the performance of the method was evaluated successfully in real samples including drinking water, tap water and river water.

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A novel platform sensing based on combination of electromembrane-assisted solid phase microextraction with linear sweep voltammetry for the determination of tramadol

Cited by 35 publications

References 42 publications

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs

Development of a novel LC–MS/MS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs: Application to counterfeit study

Determination of 4‐Nitrobenzaldehyde in Water Samples by Combination of Switchable Solvent Based Microextraction and Electrochemical Detection on MWCNTs Modified Electrode

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