A Novel Plasma-Based Fluid for Particle Image Velocimetry (PIV): In-Vitro Feasibility Study of Flow Diverter Effects in Aneurysm Model

Clauser, Johanna; Knieps, Marius S.; Büsen, Martin; Ding, Andreas; Schmitz‐Rode, Thomas; Steinseifer, Ulrich; Cattaneo, Giorgio

doi:10.1007/s10439-018-2002-1

Cited by 15 publications

(12 citation statements)

References 21 publications

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“…However, for vessels with diameter larger than 1 mm it has been proven in former studies that blood behaviour can be approximated as Newtonian fluid. [22,23] A newly developed PIV plasma with rheological and coagulation properties has been reported by Clauser et al [24]. The viscosity used in our study is at the upper range of their study.…”

Section: Artery Propertiesmentioning

confidence: 81%

Comparative Study of Wall-Shear Stress at the Ascending Aorta for Different Mechanical Heart Valve Prostheses

Hegner

Brücker

2019

Journal of Biomechanical Engineering

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An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing a bileaflet mechanical heart valve (BMHV) with a trileaflet mechanical heart valve (TMHV) in physiological pulsatile flow. Elastic micro-pillar WSS sensors, calibrated by micro-Particle-Image-Velocimetry measurement, are applied to the wall along the ascending aorta (AAo). Peak WSS values are observed almost twice in BMHV compared to TMHV.Flow field analyses illuminate that these peaks are linked to the jet-like flows generated in the valves interacting with the aortic wall. Not only the magnitude but also the impact regions are specific for the different valve designs. The side-orifice jets generated by BMHV travel along the aortic wall in the AAo and cause a whole range impact, while the jets generated by TMHV impact further downstream in the AAo generating less severe WSS.

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Section: Artery Propertiesmentioning

confidence: 81%

Comparative Study of Wall-Shear Stress at the Ascending Aorta for Different Mechanical Heart Valve Prostheses

Hegner

Brücker

2019

Journal of Biomechanical Engineering

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“…2b (T). Blood samples were taken post NeonatOx (6), while various other ports were used to fill (7) and drain ( 8) the blood loop, as 3), X-ray cone beam (4), object of interest/NeonatOx (5), rotational degrees of freedom (DOF) ( 6), translational DOF ( 7), flat panel detector (8), distance between source and NeonatOx of 750 mm ( 9), distance between NeonatOx and detector of 1445 mm (10).…”

Section: In-vitro Blood Loopmentioning

confidence: 99%

In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study

Kaesler

Rudawski

Zander

et al. 2021

Cardiovasc Eng Tech

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Purpose Extracorporeal membrane oxygenation has gained increasing attention in the treatment of patients with acute and chronic cardiopulmonary and respiratory failure. However, clotting within the oxygenators or other components of the extracorporeal circuit remains a major complication that necessitates at least a device exchange and bears risks of adverse events for the patients. In order to better predict thrombus growth within oxygenators, we present an approach for in-vitro visualization of thrombus growth using real-time X-ray imaging. Methods An in-vitro test setup was developed using low-dose anticoagulated ovine blood and allowing for thrombus growth within 4 h. The setup was installed in a custom-made X-ray setup that uses phase-contrast for imaging, thus providing enhanced soft-tissue contrast, which improves the differentiation between blood and potential thrombus growth. During experimentation, blood samples were drawn for the analysis of blood count, activated partial thromboplastin time and activated clotting time. Additionally, pressure and flow data was monitored and a full 360° X-ray scan was performed every 15 min. Results Thrombus formation indicated by a pressure drop and changing blood parameters was monitored in all three test devices. Red and white thrombi (higher/lower attenuation, respectively) were successfully segmented in one set of X-ray images. Conclusion We showed the feasibility of a new in-vitro method for real-time thrombus growth visualization by means of phase contrast X-ray imaging. In addition, with more blood parameters that are clinically relevant, this approach might contribute to improved oxygenator exchange protocols in the clinical routine.

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“…[13][14][15][16][17] In vitro studies aim to understand some of the general features of aneurysm thrombosis, which would otherwise be difficult to grasp in a pathology which has such wide variability among different patients. 18,19 The attempt to manage the wide variability of outcomes has led to the development of various computational models of cerebral aneurysm thrombosis. [20][21][22][23][24][25][26] The intended goal of these models is interventional planning, where prediction of outcomes such as clotting can provide additional information to the clinician about a specific patient's prospects.…”

Section: Introductionmentioning

confidence: 99%

“… 13 14 15 16 17 In vitro studies aim to understand some of the general features of aneurysm thrombosis, which would otherwise be difficult to grasp in a pathology which has such wide variability among different patients. 18 19 …”

Section: Introductionmentioning

confidence: 99%

Thrombin–Fibrinogen In Vitro Flow Model of Thrombus Growth in Cerebral Aneurysms

Ngoepe

Pretorius

Shaikh

et al. 2021

TH Open

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Cerebral aneurysms are balloon-like structures that develop on weakened areas of cerebral artery walls, with a significant risk of rupture. Thrombi formation is closely associated with cerebral aneurysms and has been observed both before and after intervention, leading to a wide variability of outcomes in patients with the condition. The attempt to manage the outcomes has led to the development of various computational models of cerebral aneurysm thrombosis. In the current study, we developed a simplified thrombin–fibrinogen flow system, based on commercially available purified human-derived plasma proteins, which enables thrombus growth and tracking in an idealized cerebral aneurysm geometry. A three-dimensional printed geometry of an idealized cerebral aneurysm and parent vessel configuration was developed. An unexpected outcome was that this phantom-based flow model allowed us to track clot growth over a period of time, by using optical imaging to record the progression of the growing clot into the flow field. Image processing techniques were subsequently used to extract important quantitative metrics from the imaging dataset, such as end point intracranial thrombus volume. The model clearly demonstrates that clot formation, in cerebral aneurysms, is a complex interplay between mechanics and biochemistry. This system is beneficial for verifying computational models of cerebral aneurysm thrombosis, particularly those focusing on initial angiographic occlusion outcomes, and will also assist manufacturers in optimizing interventional device designs.

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A Novel Plasma-Based Fluid for Particle Image Velocimetry (PIV): In-Vitro Feasibility Study of Flow Diverter Effects in Aneurysm Model

Cited by 15 publications

References 21 publications

Comparative Study of Wall-Shear Stress at the Ascending Aorta for Different Mechanical Heart Valve Prostheses

Comparative Study of Wall-Shear Stress at the Ascending Aorta for Different Mechanical Heart Valve Prostheses

In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study

Thrombin–Fibrinogen In Vitro Flow Model of Thrombus Growth in Cerebral Aneurysms

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