A novel peptide ‘T14’ reflects age and photo-aging in human skin

Rocha, Sheila; Ratés, Sara Garcia; Moswete, Tumisang; Kalleberg, Kristopher; Villa, Anna; Harcup, Jason P.; Greenfield, Susan A.

doi:10.18632/aging.204844

Cited by 3 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T14 reduces aging through its main defense process by strengthening the skin barrier, improving skin elasticity, and promoting the repair of damaged tissues. These effects help maintain the structure and function of the skin, thereby resisting the skin aging process [58].…”

Section: Enhanced Barrier and Repair Effectsmentioning

confidence: 99%

Research Progress on Bioactive Factors against Skin Aging

He,

Gao,

Guo

et al. 2024

IJMS

View full text Add to dashboard Cite

The relentless pursuit of effective strategies against skin aging has led to significant interest in the role of bioactive factors, particularly secondary metabolites from natural sources. The purpose of this study is to meticulously explore and summarize the recent advancements in understanding and utilization of bioactive factors against skin aging, with a focus on their sources, mechanisms of action, and therapeutic potential. Skin, the largest organ of the body, directly interacts with the external environment, making it susceptible to aging influenced by factors such as UV radiation, pollution, and oxidative stress. Among various interventions, bioactive factors, including peptides, amino acids, and secondary metabolites, have shown promising anti-aging effects by modulating the biological pathways associated with skin integrity and youthfulness. This article provides a comprehensive overview of these bioactive compounds, emphasizing collagen peptides, antioxidants, and herbal extracts, and discusses their effectiveness in promoting collagen synthesis, enhancing skin barrier function, and mitigating the visible signs of aging. By presenting a synthesis of the current research, this study aims to highlight the therapeutic potential of these bioactive factors in developing innovative anti-aging skin care solutions, thereby contributing to the broader field of dermatological research and offering new perspectives for future studies. Our findings underscore the importance of the continued exploration of bioactive compounds for their potential to revolutionize anti-aging skin care and improve skin health and aesthetics.

show abstract

Section: Enhanced Barrier and Repair Effectsmentioning

confidence: 99%

Research Progress on Bioactive Factors against Skin Aging

He,

Gao,

Guo

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Furthermore, nasal secretions may be informative given that a significant proportion of their content has been shown to derive from CSF in non‐human animals 36 ; these secretions have already been used in a lateral flow format to detect β‐amyloid changes in AD. 37 It should be noted that age‐dependent levels of T14 have been detected at the epidermis, 38 a site at which pathological aberrations have been associated with neurodegenerative disease including AD. 39 Since Parkinson's disease has been detected by a change in chemical composition of sebum, 40 sebum may offer a further matrix for diagnostic detection of T14 in AD.…”

Section: Eventual Clinical Applications Based On the T14 Systemmentioning

confidence: 99%

Evidence for a novel neuronal mechanism driving Alzheimer's disease, upstream of amyloid

Garcia Ratés,

García‐Ayllón,

Falgàs

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

This perspective offers an alternative to the amyloid hypothesis in the etiology of Alzheimer's disease (AD). We review evidence for a novel signaling mechanism based on a little‐known peptide, T14. T14 could drive neurodegeneration as an aberrantly activated process of plasticity selective to interconnecting subcortical nuclei, the isodendritic core, where cell loss starts at the pre‐symptomatic stages of the disease. Each of these cell groups has the capacity to form T14, which can stimulate production of p‐Tau and β‐amyloid, suggestive of an upstream driver of neurodegeneration. Moreover, results in an animal AD model show that antagonism of T14 with a cyclated variant, NBP14, prevents formation of β‐amyloid, and restores cognitive function to that of wild‐type counterparts. Any diagnostic and/or therapeutic strategy based on T14‐NBP14 awaits validation in clinical trials. However, an understanding of this novel signaling system could bring much‐needed fresh insights into the progression of cell loss underlying AD.Highlights The possible primary mechanism of neurodegeneration upstream of amyloid. Primary involvement of selectively vulnerable subcortical nuclei, isodendritic core. Bioactive peptide T14 trophic in development but toxic in context of mature brain. Potential for early‐stage biomarker to detect Alzheimer's disease. Effective therapeutic halting neurodegeneration, validated already in 5XFAD mice.

show abstract

A Novel Peptide Driving Neurodegeneration Appears Exclusively Linked to the α7 Nicotinic Acetylcholine Receptor

Ranglani,

Hasan,

Komorowska

et al. 2024

Mol Neurobiol

View full text Add to dashboard Cite

T14, a 14mer peptide, is significantly increased in the pre-symptomatic Alzheimer’s disease brain, and growing evidence implies its pivotal role in neurodegeneration. Here, we explore the subsequent intracellular events following binding of T14 to its target α7 nicotinic acetylcholine receptor (nAChR). Specifically, we test how various experimental manipulations of PC12 cells impact T14-induced functional outcomes. Three preparations were compared: (i) undifferentiated vs. NGF-differentiated cells; (ii) cells transfected with an overexpression of the target α7 nAChR vs. wild type cells; (iii) cells transfected with a mutant α7 nAChR containing a mutation in the G protein-binding cluster, vs. cells transfected with an overexpression of the target α7 nAChR, in three functional assays – calcium influx, cell viability, and acetylcholinesterase release. NGF-differentiated PC12 cells were less sensitive than undifferentiated cells to the concentration-dependent T14 treatment, in all the functional assays performed. The overexpression of α7 nAChR in PC12 cells promoted enhanced calcium influx when compared with the wild type PC12 cells. The α7345–348 A mutation effectively abolished the T14-triggered responses across all the readouts observed. The close relationship between T14 and the α7 nAChR was further evidenced in the more physiological preparation of ex vivo rat brain, where T30 increased α7 nAChR mRNA, and finally in human brain post-mortem, where levels of T14 and α7 nAChR exhibited a strong correlation, reflecting the progression of neurodegeneration. Taken together these data would make it hard to account for T14 binding to any other receptor, and thus interception at this binding site would make a very attractive and remarkably specific therapeutic strategy.

show abstract

A novel peptide ‘T14’ reflects age and photo-aging in human skin

Cited by 3 publications

References 42 publications

Research Progress on Bioactive Factors against Skin Aging

Research Progress on Bioactive Factors against Skin Aging

Evidence for a novel neuronal mechanism driving Alzheimer's disease, upstream of amyloid

A Novel Peptide Driving Neurodegeneration Appears Exclusively Linked to the α7 Nicotinic Acetylcholine Receptor

Contact Info

Product

Resources

About