A novel paper-based device coupled with a silver nanoparticle-modified boron-doped diamond electrode for cholesterol detection

Nantaphol, Siriwan; Chailapakul, Orawon; Siangproh, Weena

doi:10.1016/j.aca.2015.08.007

Cited by 76 publications

(41 citation statements)

References 41 publications

(28 reference statements)

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“…The H 2 O 2 generated by the enzymatic reaction in the presence of cholesterol was reduced at the NPs modified working electrode, generating a current signal that was measured by amperometry. The biosensor exhibited a high selectivity for cholesterol detection and an excellent performance in terms of detection limits (comparable to other previously reported biosensors) and for real sample analysis (bovine serum) [41]. …”

Section: Paper-based Electrochemical Biosensorssupporting

confidence: 68%

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Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

2016

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From the bench-mark work on microfluidics from the Whitesides’s group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the great potential for the development of advanced and eco-friendly analytical tools. Consequently, paper was quickly employed in the field of electrochemical sensors, being an ideal material for producing custom, tailored and miniaturized devices. Stencil-, inkjet-, or screen-printing are the preferential techniques for electrode manufacturing. Not surprisingly, we witnessed a rapid increase in the number of publications on paper based screen-printed sensors at the turn of the past decade. Among the sensing strategies, various biosensors, coupling electrochemical detectors with biomolecules, have been proposed. This work provides a critical review and a discussion on the future progress of paper technology in the context of miniaturized printed electrochemical biosensors.

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Section: Paper-based Electrochemical Biosensorssupporting

confidence: 68%

“…In a different approach, Nantaphol et al developed a cholesterol biosensor by coupling a paper analytical device with a commercial boron-doped diamond electrode [41]. The paper section had carbon counter and Ag/AgCl reference electrodes screen-printed on its hydrophilic areas.…”

Section: Paper-based Electrochemical Biosensorsmentioning

confidence: 99%

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

2016

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“…Considering the manual processing for manufacturing ePADs, the achieved RSD is acceptable and demonstrates that the proposed approach exhibits high reproducibility. It is important to highlight that the RSD values achieved in this current study are lower than most reports associated with ePADs created with graphite pencil . The low RSD values can be associated with the use of a polyester mold for defining the electrode area, which ensures better reproducibility.…”

Section: Resultsmentioning

confidence: 61%

“…While the performance of the ePADs is below other references , two advantages need to be highlighted. First, ePADs were prepared and used without any modification with nanomaterials or charge transfer mediators.…”

Section: Resultsmentioning

confidence: 99%

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

et al. 2018

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The adulteration of whiskey with analgesics and sedation drugs has been a common practice to prevent hangover the following day and promote loss of consciousness. In both situations, the portable and low cost detection platforms are of paramount importance for forensic investigations. This report describes the use of electrochemical paper‐based analytical devices (ePADs) fabricated by pencil drawing for detecting metamizole, paracetamol and midazolam maleate in whiskey. Different types of paper substrates and graphite pencils were initially characterized with ferrocyanide. The best results were achieved using vegetal paper and Aquarelle/6B pencils. ePADs revealed a decrease in current signal indicating a short lifetime, thus limiting their use to disposable sensors. Despite the short lifetime, the graphite pencil ePADs revealed good electrochemical reproducibility (RSD=3.3 %). The forensic feasibility of the proposed ePADs was demonstrated through the analysis of metamizole and paracetamol in whiskey. The limit of detection (LOD) achieved for paracetamol and metamizole were 45 and 20 mg L−1, respectively. ePADs were also tested to detect midazolam maleate in whiskey. The signal recorded exhibited linear correlation in a wide concentration range (25–1000 mg L−1) and a LOD of ca. 5 mg L−1. Considering the disposability and operational simplicity, ePADs offer a good strategy for detecting adulterations in alcoholic beverages at the point‐of‐need.

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“…However, the results obtained with the developed NiO modified graphite based µPAD are superior to those reported in terms of both linear range and detection limit. Nantaphol et al have developed Ag nanoparticle modified boron doped diamond electrode and integrated it with the paper based microchannels . The fabrication of electrode and channels separately complicates the device design and the use of Ag and diamond electrodes increases the relative cost of the sensor.…”

Section: Resultsmentioning

confidence: 78%

A Simple Paper Based Microfluidic Electrochemical Biosensor for Point‐of‐Care Cholesterol Diagnostics

Kaur

Tomar

Gupta

2017

Physica Status Solidi (a)

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Paper based microfluidic devices have emerged as a simple and low cost platform for efficient clinical diagnostics. An effort has been made in the present work to develop a microfluidic cholesterol biosensor using paper based platform. Microfluidic channels have been fabricated by patterning filter paper (Whatman 1) using photolithography. SU 8 photoresist formed a hydrophobic barrier on the paper with microchannels of dimensions 1000 μm(w)×100 μm(t). A three electrode system was fabricated by simple mask printing of graphite as the working, as well as the counter electrodes, and silver as the reference electrode. The working electrode was modified using nickel oxide nanoparticles prepared using co‐precipitation method. Cholesterol oxidase enzyme is spotted on the test zone and chronoamperometric measurements are taken for different concentrations of cholesterol in the range of 0.12–10.23 mM, giving a quick and sensitive detection with a sensitivity of 24 µA mM−1 cm−2.

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A novel paper-based device coupled with a silver nanoparticle-modified boron-doped diamond electrode for cholesterol detection

Cited by 76 publications

References 41 publications

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

A Simple Paper Based Microfluidic Electrochemical Biosensor for Point‐of‐Care Cholesterol Diagnostics

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