A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome

Kotani, Kazuhiko; Satoh, Noriko; Kato, Yasuhisa; Araki, Rika; Kanemaru, Kazunori; Okajima, Taiichiro; Tanabe, Makito; Oishi, Mariko; Yamakage, Hajime; Yamada, Kazunori; Hattori, Masao; Shimatsu, Akira

doi:10.1016/j.atherosclerosis.2008.09.017

Cited by 43 publications

(41 citation statements)

References 25 publications

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“…The close association between SAA-LDL and inflammation is consistent with a previous report 23) . In contrast, the AT-LDL level was significantly and most closely associated with the current smoking status even after allowing for potential confounders in multiple logistic regression analysis.…”

Section: Discussionsupporting

confidence: 81%

“…Plasma levels of HbA1c, and serum levels of HDL-C, and LDL-C were measured using an automatic analyzer (LABOSPECT 008; Hitachi HighTechnologies Co., Ltd., Tokyo, Japan) with enzymebased reagents (Kyowa Medex Co., Ltd., Tokyo, Japan). Serum levels of AT-LDL and SAA-LDL were measured employing specific sandwich enzyme-linked immunosorbent assays (Ikagaku Co. Ltd., Kyoto, Japan), and the details are described elsewhere 23) . Briefly, mixed solutions of VLDL and LDL isolated from serum by polyanion precipitation 35) were measured using anti-human polyclonal antibodies against SAA or AT (DAKO Denmark A/S, Glostrup, Denmark) as the primary antibodies and anti-human apoB monoclonal antibody (SAA-LDL, clone No.…”

Section: Data Collectionmentioning

confidence: 99%

“…One is a complex between serum amyloid A (SAA) and LDLs (SAA-LDL), which is formed from the oxidative interaction between SAA and LDLs 22) . Circulating SAA-LDL levels are closely associated with inflammation, obesity, and metabolic syndrome (MetS) 23) . Furthermore, the SAA-LDL level seems to be a more sensitive prognostic marker than C-reactive protein (CRP) or SAA in patients with stable coronary artery disease 22) .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the SAA-LDL level seems to be a more sensitive prognostic marker than C-reactive protein (CRP) or SAA in patients with stable coronary artery disease 22) . The other is a complex between oxidized 1-antitrypsin and LDLs (AT-LDL) 23) . 1-Antitrypsin (AT) is a serine-proteinase inhibitor that protects tissue against damage caused by proteinases.…”

Section: Introductionmentioning

confidence: 99%

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α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress

Wada

Ura

Satoh‐Asahara

et al. 2012

JAT

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Aim: While smoking cessation (SC) leads to a reduction of cardiovascular events, atherogenic biomarkers specifically connected with cigarette smoking and SC are unknown. Circulating levels of oxidatively modified low-density-lipoprotein (LDL) are associated with a high risk of cardiovascular diseases. Recently, two novel, oxidatively modified LDL markers, serum amyloid A-LDL (SAA-LDL) and 1-antitrypsin-LDL (AT-LDL), were identified; however, the significance of SAA-LDL and AT-LDL as cardiovascular risk markers is unknown. Methods: We carried out a cross-sectional study involving 243 patients, and determined serum levels of SAA-LDL and AT-LDL. Results: Both serum levels of SAA-LDL and AT-LDL were significantly increased in current compared to non-current smokers. Stepwise regression analysis revealed that the current smoking status and duration of smoking were strong independent determinants of the AT-LDL level. In contrast, high-sensitivity C-reactive protein was the strongest determinant of the SAA-LDL level. In multiple logistic regression analysis, the current smoking status was most closely associated with the AT-LDL level. Successful SC employing a 12-week program significantly increased the body mass index and serum levels of obesity-related markers. Notably, successful SC significantly decreased levels of AT-LDL, but not those of SAA-LDL. Conclusions:The present study provides the first evidence for the distinct characteristics of two novel, oxidatively modified LDL markers, SAA-LDL and AT-LDL. In contrast to SAA-LDL, an inflammatory marker, AT-LDL serves as a marker of smoking-specific oxidative stress. These findings warrant further investigations to clarify if AT-LDL provides a key link between smoking and cardiovascular diseases.

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Section: Discussionsupporting

confidence: 81%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress

Wada

Ura

Satoh‐Asahara

et al. 2012

JAT

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“…In a series of previous studies, we demonstrated that as a new atherogenic index, cardio-ankle vascular index (CAVI) and serum amyloid A-oxidized LDL are useful for the evaluation and management of the CVD risks in patients with obesity and MS (22,23). We also reported that the markers are sensitive for detecting improvement of CVD risks during weight reduction.…”

Section: Introductionmentioning

confidence: 97%

Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome

Satoh‐Asahara¹,

Suganami²,

Majima³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and Objectives Obesity and metabolic syndrome (MS) increase the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and all-cause mortality. Serum cystatin C (S-CysC), a marker of GFR, has been shown to be associated with CVD and CKD. This study was designed to elucidate the association of urinary CysC (U-CysC), a marker of renal tubular dysfunction, with CVD and CKD risk factors in patients with obesity and MS. Design, setting, participants, & measurementsThe U-CysC-creatinine ratio (UCCR) was examined in 343 Japanese obese outpatients enrolled in the multi-centered Japan Obesity and Metabolic Syndrome Study.Results UCCR was positively correlated with urine albumin-creatinine ratio (UACR) and S-CysC and negatively correlated with estimated GFR (eGFR). Among obese patients, UCCR was significantly higher in MS patients than in non-MS patients. UCCR had significant correlations with the number of components of MS and arterial stiffness, all of which are CVD predictors, similarly to UACR (P Ͻ 0.05). Interestingly, diet-and exercise-induced weight reduction for 3 months significantly decreased only UCCR among all of the renal markers examined (P Ͻ 0.01), in parallel with the decrease in BMI, HbA1c, and arterial stiffness, suggesting the beneficial effect of weight reduction on renal tubular dysfunction. ConclusionsThis study demonstrates that UCCR is significantly associated with renal dysfunction, the severity of MS, arterial stiffness, and weight change in obese patients. The data of this study suggest that UCysC could serve as a CVD and CKD risk factor in patients with obesity and MS.

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Altered Composition

2011

High‐Density Lipoproteins

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A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome

Cited by 43 publications

References 25 publications

α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress

α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress

Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome

Altered Composition

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