A novel organic–inorganic hybrid conducting copolymer for mediated biosensor applications

Soganci, Tugba; Demirkol, Dilek Odaci; Ak, Metin; Tımur, Suna

doi:10.1039/c4ra07516a

Cited by 43 publications

(34 citation statements)

References 45 publications

(38 reference statements)

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“…A more hydrophobic nature of the biomolecule conjugated surface due to the presence of different hydrophobic amino acids was evident through an increase in advancing angle from 58.84 ± 0.70° to 86.63 ± 1.30° by the GOx immobilization. The enhanced hydrophilic character is resulted from the carboxylic acid groups present in the enzyme structure …”

Section: Resultsmentioning

confidence: 99%

“…The direct or indirect immobilization of enzymes on the modified electrode surface is an important issue for biosensor design . Enzyme‐based glucose biosensors offer several advantages, such as operational stability, higher selectivity, operational simplicity, and suitability for real‐time detection, and are extensively used in the determination of glucose concentrations in beverages and in the blood for the diagnosis and treatment of diabetes mellitus . Thus, the development of low‐cost, high sensitive, stable, and rapid biosensors draws substantial interest.…”

Section: Introductionmentioning

confidence: 99%

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Bioapplications of Polythiophene-g-Polyphenylalanine-Covered Surfaces

Guler

Akbulut

Bozokalfa

et al. 2015

Macromol. Chem. Phys.

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The fabrication of electro and bioactive surfaces by electrochemical deposition of the thiophene-functionalized polyphenylalanine macromonomer (T-g -PPhe) is reported. The resulting conducting graft copolymer, polythiophene-graft -polyphenylalanine (PT-g -PPhe) formed on the indium tin oxide (ITO) glass surface, is characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and fl uorescence microscopy. Then, possible uses of PT-g -PPhe as matrices in the sensor design for both electrochemical biosensing and cell adhesion studies are investigated. In the fi rst part, PT-g -PPhe that is deposited on ITO is further functionalized with the arginylglycylaspartic acid peptide via 1-Ethyl-3-(3 dimethylaminopropyl) carbodiimide for the selective cell adhesion. Immunofl uorescence staining is performed to detect the difference between adherences of "integrin αvβ3" receptor positive (U87-MG) and negative (HaCaT) cell lines on to the biofunctional surface. In the second part, an electrochemical glucose sensor is constructed by immobilizing glucose oxidase on the surface of PT-g -PPhe, which is deposited on a glassy carbon electrode.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioapplications of Polythiophene-g-Polyphenylalanine-Covered Surfaces

Guler

Akbulut

Bozokalfa

et al. 2015

Macromol. Chem. Phys.

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“…porphyrins [8][9][10], ferrocene [11][12][13], crown ether [14][15][16], Schiff base [17][18][19] and bipyridine [20][21][22], are known. However, very few have incorporated a thiophene group or derivative into its structure [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and electrochemical characterization of new ruthenium–terthiophene complexes

et al. 2015

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“…[21] Biosensor applications investigated that ferrocene group on the polymer chain was used as a redox mediator. [22,23] In this study, firstly conjugated amido ferrocenyldithiophosphonate compound, namely 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)amido ferrocenyldithiophosphonate (2) was synthesized via reaction of [(FcPS 2 )] 2 and 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline (1). After that, O-diacetyl-dglucose-ferrocenyldithiophosphonate (3) was synthesized via reaction of [(FcPS 2 )] 2 and diacetone-d-glucose.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of new ferrocenyldithiophosphonate derivatives: electrochemical, electrochromic, and optical properties

Ayrancı

Ocal

et al. 2016

Designed Monomers and Polymers

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In this study, three ferrocenyl dithiophosphonate derivatives were synthesized and characterized by elemental analyses, IR, and NMR ( 1 H-, 31 P-) spectroscopy. Electroactivities of synthesized molecules were determined by cyclic voltammetry experiments. It was shown that all molecules were electroactive and only one of them that contained conjugated structure could polymerized by electrochemical experiments. Characterization of electrosynthesized metallopolymer was realized and electrochromic and spectroelectrochemical properties were investigated. The onset energy for the π-π * transition (electronic band gap), HOMO, and LUMO energy levels were calculated as 2.31, −4.44, and 2.13 eV, respectively. Switching time and optical contrast values of metallopolymer were found as 1.5 s and 41% at 435 nm, respectively, whereas these values were found as 2.5 s and 40%, respectively, at 700 nm.

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A novel organic–inorganic hybrid conducting copolymer for mediated biosensor applications

Abstract: A novel ferrocenyldithiophosphonate (TPFc) functionalized monomer and its conductive copolymer were synthesized, characterized and its potential use for biosensor applications was investigated.

Cited by 43 publications

References 45 publications

Bioapplications of Polythiophene-g-Polyphenylalanine-Covered Surfaces

Bioapplications of Polythiophene-g-Polyphenylalanine-Covered Surfaces

Synthesis and electrochemical characterization of new ruthenium–terthiophene complexes

Synthesis of new ferrocenyldithiophosphonate derivatives: electrochemical, electrochromic, and optical properties

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