A novel “off-on-off” fluorescent sensor based on inner filter effect for ultrasensitive detection of protamine/trypsin and subcellular colocalization

A Si‐CdTe Composite Quantum Dots Probe with Dual‐Wavelength Emission for Sensitively Monitoring Intracellular H2O2

“…This may be because, in SiCdTe QDs, the part of CdTe QDs is not only protected by TGA cap but also has an outer layer of encapsulated nontoxic SiQDs. [16,34] The MTT results indicate that the SiCdTe QDs have low toxicity, which is a prerequisite for tumor cell imaging. We evaluated the applicability of our probes for bioimaging application, HeLa cells as model cells, which were incubated with 100 µg mL −1 SiCdTe QDs.…”

“…[12][13][14][15] Fluorescent probes are ideal for detecting analytes in biological sam ples because of their fast response, high selectivity, good compatibility with biolog ical samples, and nondestructive analysis capability. [16][17][18] Dong et al [19] invented a silicon oxide quantum dots (SiO QDs) and Ag nanoclusters hybrid nanosensing probe that acts as an "offon" ratio fluo rescent probe for H 2 O 2 detection. Gong et al [20] developed a H 2 O 2 probe based on a hepatitis B core antibody labeled with horseradish peroxidase (HBcAbHRP) induced fluorescent enhancement of CdTe QDs.…”

Luminescent Sensors Based on the Assembly of Coinage Metal Nanoclusters

“…Protamine is an anticoagulant that can inhibit heparin and stop bleeding but may produce side effects, such as sudden drop in blood pressure, bradycardia and dyspnea. Trypsin can hydrolyze protamine, so sensitive and reliable methods for detecting protamine and trypsin are attracting more and more attention [71]. Xue et al developed a dual-emission spherical nanohybrid probe (SiNPs@GSH-AuNCs) using electrostatic interactions for the ratio detection of protamine and trypsin [17].…”

Self-assembled super-small AIEgen nanoprobe for highly sensitive and selective detection of protamine and trypsin

“…3 However, the improper utilization of Pro could also induce many adverse effects, including hypotension, bradycardia, and anaphylactic reactions. 4,5 Trypsin (Try) is a typical serine proteolytic enzyme secreted from pancreatic acinar cells and can specifically catalyze the hydrolysis of peptides at the C-terminus of lysine and arginine residues. 6 Thus, an abnormal level of trypsin is considered as a potential biomarker for pancreatic cancer, cystic fibrosis and other intestinal pathological conditions.…”