A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY

San-Martı́n, Aurelio; Bacho, Mitchell; Núñez, S.; Rovirosa, Juana; Soler, Agnes; Blanc, Vanessa; León, Rubén; Olea, Andrés F.

doi:10.4067/s0717-97072018000304082

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Apiaceae was collected in May 2013 in the El Tatio geysers area (Atacama Desert) at an elevation of 4200 m in the Region of Antofagasta, Chile. A sample specimen was deposited at the Herbarium of Natural Products Laboratory of the Faculty of Science, Universidad de Chile, under the code n° 0513 [ 44 ]. Leaves and stems were separated and dried at ambient temperature, avoiding direct sun exposure, over three days.…”

Section: Methodsmentioning

confidence: 99%

Azorella compacta Organic Extracts Exacerbate Metabolic Dysfunction-Associated Fatty Liver Disease in Mice Fed a High-Fat Diet

Zúñiga-Hernandez,

Quiñones San Martin,

Figueroa

et al. 2024

Pharmaceuticals

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Azorella compacta (A. compacta) is a shrub of the Andean Altiplano of Bolivia, Chile and Peru, consumed by local communities as a traditional medicine for several maladies such as diabetes, hepatic and inflammatory diseases. A. compacta is rich in mulinane- and azorellane-type diterpenoids. For two of these, acute hypoglycemic effects have been described, but the impact of A. compacta diterpenoids on fatty liver disease has not been investigated. Therefore, A. compacta organic fractions were prepared using petroleum ether, dichloromethane and methanol. Their content was characterized by UHPLC/MS, revealing the presence of ten diterpenoids, mainly mulinic acid, azorellanol and mulin-11,13-diene. Next, mice fed with a high-fat diet (HFD), a model of metabolic dysfunction-associated fatty liver disease (MAFLD), received one of the fractions in drinking water for two weeks. After this treatment, hepatic parameters were evaluated. The A. compacta fractions did not reduce hyperglycemia or body weight in the HFD-fed mice but increased the serum levels of hepatic transaminases (AST and ALT), reduced albumin and increased bilirubin, indicating hepatic damage, while histopathological alterations such as steatosis, inflammation and necrosis generated by the HFD were, overall, not ameliorated by the fractions. These results suggest that organic A. compacta extracts may generate hepatic complications in patients with MAFLD.

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Section: Methodsmentioning

confidence: 99%

Azorella compacta Organic Extracts Exacerbate Metabolic Dysfunction-Associated Fatty Liver Disease in Mice Fed a High-Fat Diet

Zúñiga-Hernandez,

Quiñones San Martin,

Figueroa

et al. 2024

Pharmaceuticals

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show abstract

“…Consequently, natural product characterization and pharmacological studies have been carried out on A. compacta and related species. Numerous investigations reported structure determinations and pharmacological potential studies of the resin compounds, that were isolated and purified from the major Andean Apiaceae species, namely Mulinum and Azorella [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. This has led to a description of mainly two novel diterpenoid skeletons among the natural products, specifically the mulinanes and azorellanes ( Figure 1 ), with the assignment of their skeletal numbering conventions [ 16 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Mulinane and Azorellane Diterpenoid Biomarkers by GC-MS from a Representative Apiaceae (Umbelliferae) Species of the Andes

et al. 2019

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Extracts of bled resin from Azorella compacta, of the Azorelloideae family from the Andes (>4000 m), were analyzed by gas chromatography-mass spectrometry. The mass spectra of the dominant compounds of the resin and its hydrogenation products were documented. The most abundant compounds were oxygenated diterpenoids, namely mulinadien-20-oic (Δ11,13 and Δ11,14) acids, azorell-13-en-20-oic acid, 13α,14β-dihydroxymulin-11-en-20-oic acid, and azorellanol, with a group of azorellenes and mulinadienes. The mass spectra of the novel diterpenoid hydrocarbons with the azorellane and mulinane skeletons were also presented. This study documents the molecular diversity of these diterpenoid classes, and could be of great utility for future organic geochemical, environmental, archeological, pharmaceutical, and forensic chemistry studies.

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Identification of natural diterpenes isolated from Azorella species targeting dispersin B using in silico approaches

Rasul¹,

Sabir²,

Aziz³

et al. 2023

J Mol Model

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A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY

Cited by 5 publications

References 20 publications

Azorella compacta Organic Extracts Exacerbate Metabolic Dysfunction-Associated Fatty Liver Disease in Mice Fed a High-Fat Diet

Azorella compacta Organic Extracts Exacerbate Metabolic Dysfunction-Associated Fatty Liver Disease in Mice Fed a High-Fat Diet

Mulinane and Azorellane Diterpenoid Biomarkers by GC-MS from a Representative Apiaceae (Umbelliferae) Species of the Andes

Identification of natural diterpenes isolated from Azorella species targeting dispersin B using in silico approaches

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