A novel non-enzymatic glucose sensor based on Cu nanoparticle modified graphene sheets electrode

Luo, Jing; Jiang, Sisi; Zhang, Hongyan; Jiang, Jinqiang; Liu, Xiaoya

doi:10.1016/j.aca.2011.10.025

Cited by 518 publications

(255 citation statements)

References 44 publications

Supporting

Mentioning

242

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, they can serve on electron tunnel to promote electron exchange at electron/protein interface [16,17], and thereby gold nanoparticles have found many applications in biosensors [18,19]. Graphene (GE), a one-atom-thick sp 2 -bonded carbon sheet, has attracted tremendous attention in recent years due to its large amount of edge-plan-like defects and large specific surface area [20][21][22]. The elusive two-dimensional structure of GE contributes to numerous unique electronic properties, such as the quantum Hall effect and transport via relativistic Dirac fermions [23,24], making GE possess high electron conductivity and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of uric acid and dopamine using a carbon fiber electrode modified by layer-by-layer assembly of graphene and gold nanoparticles

et al. 2013

View full text Add to dashboard Cite

A novel layer-by-layer assembly of graphene sheets and gold nanoparticles modified carbon fiber electrode (GE/Au/GE/CFE) was successfully fabricated and applied to simultaneous determination of dopamine (DA) and uric acid (UA). The structure of GE/Au/GE/CFE was characterized by scanning electron microscopy (SEM). It was observed that the gold nanoparticles were homogeneously assembled between the two layers of GE sheets. Cyclic voltammetry (CV) measurements elucidate that GE/Au/GE/CFE has higher electrocatalytic activity for the oxidation of DA and UA when compared with graphene modified carbon fiber electrode (GE/CFE), and graphene and gold nanoparticles modified carbon fiber electrode (Au/GE/CFE). Simultaneous determination of UA and DA on GE/Au/GE/CFE was conducted with a differential pulse voltammetry technique, and two welldefined and fully resolved anodic oxidation peaks were observed. Anodic oxidation currents of DA and UA are linear with their concentration in the range of 0.59-43.96 μM and 12.6-413.62 μM, respectively. Moreover, the composite electrode displays high reproducibility and selectivity for the determination of UA and DA.

show abstract

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of uric acid and dopamine using a carbon fiber electrode modified by layer-by-layer assembly of graphene and gold nanoparticles

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Various metal oxide and metal (or metal alloy), such as Co 3 O 4 [39,40], Ni(OH) 2 [41], NiO [28,42], Ni [43], Pd [44,45], Cu [46], PtNi [47], and Au-Pt [48], have been loaded on graphene for direct glucose detection based on the their electrochemical redox behaviors or the high electrocatalytic ability. For instance, Dong and coworkers fabricated 3D graphene/Co 3 O 4 composite for electrochemical glucose detection (Fig.…”

Section: Non-enzymatic Catalysismentioning

confidence: 99%

Graphene for Glucose, Dopamine, Ascorbic Acid, and Uric Acid Detection

Han

et al. 2014

SpringerBriefs in Molecular Science

View full text Add to dashboard Cite

Since every atom in graphene single sheet is a surface atom, molecular interaction and electron transport through graphene can be highly sensitive to adsorbed biomolecules. Graphene materials act as good candidates for glucose sensing due to the high surface area, excellent conductivity, and small band gap, which are favorable for biomolecules loading and electrons conducting. Generally, graphene-based platforms for glucose determination could be categorized into two kinds, namely enzyme catalysis and non-enzyme catalysis. The enzyme catalysis shows high sensitivity and selectivity. However, the inevitable drawbacks of instability originating from the intrinsic nature of the enzyme, as well as the critical operational conditions and complicated immobilization procedure, may limit the analytical applications. These drawbacks could be overcome in non-enzyme catalytic biosensors, which are stable, simple, reliable, and cost-effective. Detailed descriptions are illustrated in the following. The concentrations of dopamine (DA), ascorbic acid (AA), and uric acid (UA) in human body are important in the diagnosis, monitoring, prevention, and treatments of some certain diseases, such as HIV infections, schizophrenia, Parkinson, hyperuricemia, and a type of arthritis. Then various graphene platforms for the detection and quantification of DA, AA, and UA are also demonstrated.Keywords Graphene Á Glucose Á Enzyme Á Dopamine Á Ascorbic acid Á Uric acid Glucose Detection Catalysis by EnzymesGlucose detection plays an important role in biotechnology, life science, food industry, and clinical diagnostics. Diabetes is a worldwide public health problem and one of the leading causes of death and disability in the world. In 2000, it was estimated that 2.8 % of the world population was affected by diabetes mellitus, a disease with hyperglycemia (i.e., elevated blood glucose level) as the major symptom

show abstract

“…Several biosensing platforms have been already identified such as graphene/Cu nanoparticles [36], graphene/Pd [37], reduced graphene oxide (RGO)-multiwalled carbon nanotube (MWCNTs) [11], and RGO/ZnO [38]. Moreover, Li et al synthesized CeO 2 -loaded graphene nanocomposites with high specific capacitance and power density [39].…”

Section: Introductionmentioning

confidence: 98%

Nano-CeO2 decorated graphene based chitosan nanocomposites as enzymatic biosensing platform: fabrication and cellular biocompatibility assessment

Mohanty

Nayak

2015

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

The present study summarizes the designing of a green transducer phase based on nano-cerium oxide (CeO2) decorated reduced graphene oxide (RGO) reinforced chitosan nanocomposites as an effective enzyme immobilizer and bio-sensing matrix for glucose analyte. Also, it scrutinizes the biocompatibility and cell viability of the synthesized nanohybrid with human fibroblastic macrophage cell line. CeO2 nanoparticles (NPs) were successfully grown on graphene nanosheet in the presence of cationic surfactant followed by facile hydrothermal treatment. The eventual growth of synthesized CeO2 nanocrystals on the graphene layer was confirmed from X-ray diffraction (XRD), transmission electron microscopy (TEM) and Raman analysis. The biocompatibility of the synthesized nanohybrid was also evident from the MTT assay. Glucose oxidase (GOx) was employed on the green polymer nanocomposites modified FTO electrode to fabricate an enzymatic bioelectrode. The electroanalytical response of the GOx/nano-CeO2/RGO/CS/FTO bioelectrode towards electrooxidation of glucose analyte was investigated by electrochemical impedance (EIS) and cyclic voltammetry (CV) study. The resulting biosensor exhibited a good electrochemical response to glucose within the linear detection range of 0.05-6.5 mM with a low detection limit of 2 μM and a sensitivity of 7.198 μA mM(-1) cm(-2). The bioelectrode also showed good shelf life (~10 weeks) and negligible interfering ability under controlled environment. The obtained results indicate that nano-CeO2/RGO nanohybrid based chitosan nanocomposites achieve a biocompatible biosensing platform for effective enzyme immobilization due to the excellent synergistic effects between the CeO2 nanoparticles and graphene sheet.

show abstract

A novel non-enzymatic glucose sensor based on Cu nanoparticle modified graphene sheets electrode

Cited by 518 publications

References 44 publications

Simultaneous determination of uric acid and dopamine using a carbon fiber electrode modified by layer-by-layer assembly of graphene and gold nanoparticles

Simultaneous determination of uric acid and dopamine using a carbon fiber electrode modified by layer-by-layer assembly of graphene and gold nanoparticles

Graphene for Glucose, Dopamine, Ascorbic Acid, and Uric Acid Detection

Nano-CeO2 decorated graphene based chitosan nanocomposites as enzymatic biosensing platform: fabrication and cellular biocompatibility assessment

Contact Info

Product

Resources

About