A novel nanotechnological mucoadhesive and fast-dissolving film for vaginal delivery of clotrimazole: design, characterization, and in vitro antifungal action

Cervi, Verônica Ferrari; Saccol, Camila Parcianello; Santos, Roberto Christ Vianna; Sari, Marcel Henrique Marcondes

doi:10.1007/s13346-022-01154-1

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…The formation of two distinct layers in the film was also confirmed through the bioadhesion test, in which the layer composed by pullulan presented values of bioadhesive strength greater than the layer composed by gellan gum. In fact, pullulan-based formulations have already been reported in the literature with bioadhesive properties [22,48]. The bioadhesion can contribute to an intimate contact of the pharmaceutical dosage form with the skin, increasing the residence time at the action site and decreasing the administration frequency.…”

Section: Discussionmentioning

confidence: 99%

“…This type of film presents heterogeneous structures, taking advantage of the best characteristics of each individual polymer, and thus, improving the physical and mechanical properties of the final film [24]. Besides, pullulan is highly hydrophilic, forming a fast-dissolving film [22]. Thus, it is possible to infer that the pullulan layer addition confers an increase in bioadhesion and occlusion values, without altering the release and skin permeation profile of SB.…”

Section: Discussionmentioning

confidence: 99%

“…Among such polysaccharides is gellan gum, which has been shown to be suitable for the formation of ultrathin films with physical and mechanical resistance and with swelling capacity, being promising for protecting the area and absorbing exudate of lesions [20,21]. Another natural polysaccharide that has attracted the interest of researchers is pullulan, which forms elastic, bioadhesive and fast-dissolving films [18,22]. In addition, it was suggested by Jeong and co-workers that pullulan may present a physical action against AD [16].…”

Section: Introductionmentioning

confidence: 99%

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Novel Pullulan/Gellan Gum Bilayer Film as a Vehicle for Silibinin-Loaded Nanocapsules in the Topical Treatment of Atopic Dermatitis

et al. 2022

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In this study a novel gellan gum/pullulan bilayer film containing silibinin-loaded nanocapsules was developed for topical treatment of atopic dermatitis (AD). The bilayer films were produced by applying a pullulan layer on a gellan gum layer incorporated with silibinin nanocapsules by two-step solvent casting method. The bilayer formation was confirmed by microscopic analysis. In vitro studies showed that pullulan imparts bioadhesitvity for the films and the presence of nanocapsules increased their occlusion factor almost 2-fold. Besides, the nano-based film presented a slow silibinin release and high affinity for cutaneous tissue. Moreover, this film presented high scavenger capacity and non-hemolytic property. In the in vivo study, interestingly, the treatments with vehicle film attenuated the scratching behavior and the ear edema in mice induced by 2,4-dinitrochlorobenzene (DNCB). However, the nano-based film containing silibinin modulated the inflammatory and oxidative parameters in a similar or more pronounced way than silibinin solution and vehicle film, as well as than hydrocortisone, a classical treatment of AD. In conclusion, these data suggest that itself gellan gum/pullulan bilayer film might attenuate the effects induced by DNCB, acting together with silibinin-loaded nanocapsules, which protected the skin from oxidative damage, improving the therapeutic effect in this AD-model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Pullulan/Gellan Gum Bilayer Film as a Vehicle for Silibinin-Loaded Nanocapsules in the Topical Treatment of Atopic Dermatitis

et al. 2022

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“…Studies have suggested that reversible gels may transform back to sol, resulting from dilution by vaginal fluids, and leak ( Yu et al., 2011 ). However, polymeric films may overcome such disadvantages and provide an accurate dose ( Cervi et al., 2022 ). Ocular delivery systems do not have such concerns, although the films’ dosage form may be excessively irritating.…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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Fungal diseases have posed a great challenge to global health, but have fewer solutions compared to bacterial and viral infections. Development and application of new treatment modalities for fungi are limited by their inherent essential properties as eukaryotes. The microorganism identification and drug sensitivity analyze are limited by their proliferation rates. Moreover, there are currently no vaccines for prevention. Polymer science and related interdisciplinary technologies have revolutionized the field of fungal disease management. To date, numerous advanced polymer-based systems have been developed for management of fungal diseases, including prevention, diagnosis, treatment and monitoring. In this review, we provide an overview of current needs and advances in polymer-based strategies against fungal diseases. We high light various treatment modalities. Delivery systems of antifungal drugs, systems based on polymers’ innate antifungal activities, and photodynamic therapies each follow their own mechanisms and unique design clues. We also discuss various prevention strategies including immunization and antifungal medical devices, and further describe point-of-care testing platforms as futuristic diagnostic and monitoring tools. The broad application of polymer-based strategies for both public and personal health management is prospected and integrated systems have become a promising direction. However, there is a gap between experimental studies and clinical translation. In future, well-designed in vivo trials should be conducted to reveal the underlying mechanisms and explore the efficacy as well as biosafety of polymer-based products.

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Pullulan in pharmaceutical and cosmeceutical formulations: A review

Singh

Kaur

Singh

et al. 2023

International Journal of Biological Macromolecules

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A novel nanotechnological mucoadhesive and fast-dissolving film for vaginal delivery of clotrimazole: design, characterization, and in vitro antifungal action

Cited by 8 publications

References 36 publications

Novel Pullulan/Gellan Gum Bilayer Film as a Vehicle for Silibinin-Loaded Nanocapsules in the Topical Treatment of Atopic Dermatitis

Novel Pullulan/Gellan Gum Bilayer Film as a Vehicle for Silibinin-Loaded Nanocapsules in the Topical Treatment of Atopic Dermatitis

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Pullulan in pharmaceutical and cosmeceutical formulations: A review

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