Pullulan in pharmaceutical and cosmeceutical formulations: A review

Singh, Ram Sarup; Kaur, Navpreet; Singh, Devinder; Purewal, Sukhvinder Singh; Kennedy, John F.

doi:10.1016/j.ijbiomac.2023.123353

Cited by 39 publications

(11 citation statements)

References 138 publications

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“…The viscosity of pullulan in water is not affected over a wide range of pH (2–11) and remains stable in the presence of most metal ions (Jindal and Khattar 2018 ; Tsujisaka and Mitsuhashi 1993 ). With its unique structure and being non-toxic and non-irritant to the human body, it is a potent candidate for pharmaceutical and cosmeceutical applications (Singh et al 2023 ). Pullulan can be used as a carrier for the controlled release of compounds into the environment.…”

Section: Bioproducts From Aureobasidiummentioning

confidence: 99%

“…Pullulan can be used as a carrier for the controlled release of compounds into the environment. In particular, pullulan-based conjugates have been developed for prolonged intravitreal drug release (Lu et al 2009 ; Singh et al 2023 ; Zhang et al 2011 ). Also, active ingredients used in cosmetics and lotions can be targeted to site-specific skin layers (Nakashio et al 1976 ; Singh et al 2008 ).…”

Section: Bioproducts From Aureobasidiummentioning

confidence: 99%

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Use of Aureobasidium in a sustainable economy

Rensink,

van Nieuwenhuijzen,

Sailer

et al. 2024

Appl Microbiol Biotechnol

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Aureobasidium is omnipresent and can be isolated from air, water bodies, soil, wood, and other plant materials, as well as inorganic materials such as rocks and marble. A total of 32 species of this fungal genus have been identified at the level of DNA, of which Aureobasidium pullulans is best known. Aureobasidium is of interest for a sustainable economy because it can be used to produce a wide variety of compounds, including enzymes, polysaccharides, and biosurfactants. Moreover, it can be used to promote plant growth and protect wood and crops. To this end, Aureobasidium cells adhere to wood or plants by producing extracellular polysaccharides, thereby forming a biofilm. This biofilm provides a sustainable alternative to petrol-based coatings and toxic chemicals. This and the fact that Aureobasidium biofilms have the potential of self-repair make them a potential engineered living material avant la lettre. Key points •Aureobasidium produces products of interest to the industry •Aureobasidium can stimulate plant growth and protect crops •Biofinish of A. pullulans is a sustainable alternative to petrol-based coatings •Aureobasidium biofilms have the potential to function as engineered living materials

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Section: Bioproducts From Aureobasidiummentioning

confidence: 99%

Section: Bioproducts From Aureobasidiummentioning

confidence: 99%

Use of Aureobasidium in a sustainable economy

Rensink,

van Nieuwenhuijzen,

Sailer

et al. 2024

Appl Microbiol Biotechnol

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“…PULL is obtained from the fungus Aureobasidium pullulans. Differently from other polysaccharide types, PULL can easily dissolve in water thanks to the low degree of hydrogen bonding in the structure . It has been previously reported that electrospun nanofibrous webs of PULL can be used for drug transportation, filtration, medical scaffolds, and food packaging. − PULL can also be electrospun into NFs along with the combination of a variety of drug molecules to create FDDSs. , …”

Section: Introductionmentioning

confidence: 99%

Fast-Disintegrating Nanofibrous Web of Pullulan/Griseofulvin–Cyclodextrin Inclusion Complexes

et al. 2023

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Griseofulvin (GSF) is one of the most widely used antifungal suffering from low water solubility and limited bioavailability. Here, cyclodextrin (CD) derivatives of hydroxypropyl-beta-CD (HPβCD) known for its high-water solubility were used to form inclusion complexes (ICs) with GSF. Here, the molecular modeling study revealed the more efficient complex formation with 1:2 (guest:CD) stoichiometry, so ICs of GSF-HPβCD were prepared using a 1:2 molar ratio (GSF:HPβCD) and then mixed with pullulan (PULL) to generate nanofibers (NFs) using the electrospinning technique. PULL is a nontoxic watersoluble biopolymer and the ultimate PULL/GSF-HPβCD-IC NF was obtained with a defect-free fiber morphology having 805 ± 180 nm average diameter. The self-standing and flexible PULL/ GSF-HPβCD-IC NF was achieved to be produced with a loading efficiency of ∼98% corresponding to ∼6.4% (w/w) of drug content. In comparison, the control sample of PULL/GSF NF was formed with a lower loading efficiency value of ∼72% which equals to ∼4.7% (w/w) of GSF content. Additionally, PULL/GSF-HPβCD-IC NF provided an enhanced aqueous solubility for GSF compared to PULL/GSF NF so a faster release profile with ∼2.5 times higher released amount was obtained due to inclusion complexation between GSF and HPβCD within the nanofibrous web. On the other hand, both nanofibrous webs rapidly disintegrated (∼2 s) in the artificial saliva medium that mimics the oral cavity environment. Briefly, PULL/GSF-HPβCD-IC NF can be a promising dosage formulation as a fast-disintegrating delivery system for antifungal oral administration owing to the improved physicochemical properties of GSF.

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“…In addition, they prepared PulMA/GelMA hydrogels with improved biological properties by combining PulMA hydrogels with methacrylate gelatin (Gel/MA) [ 19 ]. In addition to these studies, it has been reported that the use of pullulan-based materials is not limited to biomedical and pharmaceutical applications; they are also used in other applications such as food, cosmetics, and the environment [ 20 , 21 , 22 , 23 , 24 ]. It has been reported that films prepared from pullulan are colorless, transparent, and edible; thus, they can be used as food packaging materials [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Super-Macroporous Pulluan Cryogels as Controlled Active Delivery Systems with Controlled Degradability

et al. 2023

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Here, super-macroporous cryogel from a natural polysaccharide, pullulan was synthesized using a cryo-crosslinking technique with divinyl sulfone (DVS) as a crosslinker. The hydrolytic degradation of the pullulan cryogel in various simulated body fluids (pH 1.0, 7.4, and 9.0 buffer solutions) was evaluated. It was observed that the pullulan cryogel degradation was much faster in the pH 9 buffer solution than the pH 1.0 and 7.4 buffer solutions in the same time period. The weight loss of the pullulan cryogel at pH 9.0 within 28 days was determined as 31% ± 2%. To demonstrate the controllable drug delivery potential of pullulan cryogels via degradation, an antibiotic, ciprofloxacin, was loaded into pullulan cryogels (pullulan-cipro), and the loading amount of drug was calculated as 105.40 ± 2.6 µg/mg. The release of ciprofloxacin from the pullulan-cipro cryogel was investigated in vitro at 37.5 °C in physiological conditions (pH 7.4). The amount of drug released within 24 h was determined as 39.26 ± 3.78 µg/mg, which is equal to 41.38% ± 3.58% of the loaded drug. Only 0.1 mg of pullulan-cipro cryogel was found to inhibit half of the growing Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) colonies for 10 min and totally eradicated within 2 h by the release of the loaded antibiotic. No significant toxicity was determined on L929 fibroblast cells for 0.1 mg drug-loaded pullulan cryogel. In contrast, even 1 mg of drug-loaded pullulan cryogel revealed slight toxicity (e.g., 66% ± 9% cell viability) because of the high concentration of released drug.

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Pullulan in pharmaceutical and cosmeceutical formulations: A review

Cited by 39 publications

References 138 publications

Use of Aureobasidium in a sustainable economy

Use of Aureobasidium in a sustainable economy

Fast-Disintegrating Nanofibrous Web of Pullulan/Griseofulvin–Cyclodextrin Inclusion Complexes

Super-Macroporous Pulluan Cryogels as Controlled Active Delivery Systems with Controlled Degradability

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