A novel nanohybrid for cancer theranostics: folate sensitized Fe₂O₃nanoparticles for colorectal cancer diagnosis and photodynamic therapy

Abstract

Folic acid functionalized iron oxide nanoparticles for colorectal cancer theranostics application.

Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment

“…For determining the cell viability, MTT [(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay was performed to initially check the cytotoxic effects of MDTFP-1. 36 A required number of cells (4 × 10 3 cells/well) were seeded in a 96 well-plate and treated with MDTFP-1 at different concentrations (0, 2, 4, 6, 8, and 10 μg/mL). After treatment, plates were reserved for 24 h at 37 °C in a humidified CO 2 -rich condition (5%).…”

Role of Nanomedicine in Redox Mediated Healing at Molecular Level

“…Another advantage of nanozymes over conventional antioxidants is the stimuli responsive initiation of activity, i.e., the functioning of the nanomaterial inside a cell can be controlled by external stimuli (light, ultra sound, magnetic field). This unique property of nanomaterials is heavily utilized in the case of photodynamic therapy (PDT) of cancer, which is a form of treatment involving light and a photosensitized nanomaterial, used in conjunction with molecular oxygen to elicit cell death [59][60][61][62]. The principle of PDT can be used in redox modulation as well, which will make the treatment more target specific without affecting other cells.…”

Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application

“…In the next step DMSO was used to solubilize the formazan salt and the absorbance was recorded using an ELISA reader (BioTek Instruments, Inc., Vermont, USA) at 595 nm. 15 Cell viability was determined as follows:…”

“…Previously, for synthesis of folic acid capped NPs for biomedical application, various approaches have been utilised, such as use of different organic linkers like 2,3-dibromopropionyl chloride (DBPC), N-hydroxysuccinimide (NHS), 1-ethyl-3-(3dimethylaminopropyl)-carbodiimide (EDC), polyethylene glycol and polylactic-coglycolic acid based attachment. [15][16][17][18][19][20] However, the use of organic linkers to functionalize nanoparticles can increase production cost as well as can reduce the efficacy of the nanosystem. So, an alternative facile strategy is extremely needed.…”