A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, <i>in vitro</i> and <i>in vivo</i> evaluation

Avasatthi, Vivek; Pawar, Harish; Dora, Chander Parkash; Bansod, Prajeet; Gill, Manjinder Singh; Suresh, Sarasija

doi:10.3109/10837450.2015.1026605

Cited by 89 publications

(53 citation statements)

References 34 publications

(39 reference statements)

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“…In the thermograms of the knitted textile substrates functionalized with NLCs (blue thermogram) either by exhaustion or by impregnation, there are two endothermic transitions between 51 and 64 °C which correspond to the endothermic transition of the cotton that occurred in the control, and to the endothermic transition of the solid lipid used (Precirol® ATO5). The endothermic transition of the solid lipid is in agreement with the obtained by Avasatthi et al (63.8 °C) [48]. Wang et al [49] demonstrated that, when Precirol® ATO5 is incorporated into NLC dispersions, No thermal transition related to the presence of omega-3 was observed, which was already expected since this compound is liquid at room temperature.…”

Section: Functionalization Of Textile Substratessupporting

confidence: 89%

Incorporation of lipid nanosystems containing omega-3 fatty acids and resveratrol in textile substrates for wound healing and anti-inflammatory applications

et al. 2019

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In the present work, lipid nanosystems containing omega-3 fatty acid (nanostructured lipid carriers, NLCs) or omega-3 fatty acid and resveratrol (liposomes) were developed to improve cotton textile substrates as dressings with anti-inflammatory properties for wound healing applications. Lipid nanosystems were incorporated into woven, non-woven and knitted cotton substrates by exhaustion and impregnation. Based on physical-chemical characterization of the textile substrates, the textile structure and type of lipid nanosystems dictated the adsorption efficiency. In the case of NLCs, the woven substrate functionalized by exhaustion had a higher omega-3 release being the most promising for wound dressing application. Whereas for liposomes, the most adequate textile was the cationized knitted fabric functionalized by impregnation, that showed a more prolonged release profile of resveratrol.

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Section: Functionalization Of Textile Substratessupporting

confidence: 89%

Incorporation of lipid nanosystems containing omega-3 fatty acids and resveratrol in textile substrates for wound healing and anti-inflammatory applications

et al. 2019

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“…More recently, Avasatthi et al used 278-nm nanostructured lipid carriers to deliver methotrexate in a mouse model. They observed slower, more prolonged release of the drug, and they revealed that the drug nanocarrier system decreases the psoriatic area and severity index, compared to drug alone in an imiquimod-induced mouse model of psoriasis [ 114 ]. Cyclosporin A is another oral drug used to inhibit T cells and induce immunosuppression in severe cases of both atopic dermatitis and psoriasis.…”

Section: Transdermal Nanocarriers For the Treatment Of Skin Diseasmentioning

confidence: 99%

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting

2016

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Transdermal drug delivery systems have been around for decades, and current technologies (e.g. patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.

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“…[46] PROPERTIES OF NANOGELS to MTX gel, and the PASI score is also get reduced in MTX-NLC formulation. [47] Like this way, Divya et al focused on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Act and aloe-emodin using natural polymer chitin. They had done with ex vivo and in vivo studies in which ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging.…”

Section: Novel and Advance Approaches For Psoriasis Nanogelmentioning

confidence: 99%

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Aggarwal¹

2018

AJP

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Psoriasis is a chronic inflammatory disease influencing 1-3% of the all-inclusive community with significant hindrance to personal quality of life. These conditions may adversely influence the patient's quality of life and prompt psychosocial stretch. Psoriasis can be arranged as mild, moderate, and severe conditions. Mild psoriasis prompts the formation of rashes, and when it ends up moderate, the skin transforms into scaly. It is important to control and limit the indications of psoriasis to give patient long-lasting protection since psoriasis is not presently curable yet it can go into reduction, creating a normal/ordinary skin surface. Customary conventional treatments for psoriasis are utilized for the treatment of incorporate topical, oral, or systemic formulation yet have a potential for long-term danger and may not generally give adequate change of the illness. Dermal treatment guaranteeing percutaneous penetration is presently very suggested in topical signs for psoriatic patients, which can be accomplished utilizing pharmaceutical nanotransporters nanovesicle and nanoparticle and so forth. The advancement of novel treatments focusing on the pathogenesis of psoriasis presently gives new and efficient treatment alternatives such as nanoparticulate/nanovesicular gels, which are more powerful in diminishment of purities, scaling, and hyperkeratosis of psoriasis plaque. Because of high drug loading, productivity, and stability, novel transporter diminishes the scaly patches and decreases of humoral immunity. Point of the survey is to center around the effect of nanotechnology construct drug delivery approaches in light of different anti-psoriasis drugs delivery for the fruitful treatment of psoriasis with negligible poisonous or toxic response.

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A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation

Abstract: The developed MTX-NLC gel formulation can be a promising alternative to existing MTX formulation in treating psoriasis.

Cited by 89 publications

References 34 publications

Incorporation of lipid nanosystems containing omega-3 fatty acids and resveratrol in textile substrates for wound healing and anti-inflammatory applications

Incorporation of lipid nanosystems containing omega-3 fatty acids and resveratrol in textile substrates for wound healing and anti-inflammatory applications

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting

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